Activation of the Leukocyte NADPH Oxidase by Phorbol Ester Requires the Phosphorylation of p47 on Serine 303 or 304

The respiratory burst oxidase.

1994 • 608 citations

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

1991 • 379 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

1990 • 248 citations

Activation of p38 in Stimulated Human Neutrophils: Phosphorylation of the Oxidase Component p47 by p38 and ERK but Not by JNK

1996 • 248 citations

Regulation of an Enzyme by Phosphorylation at the Active Site

1990 • 246 citations

Phosphorylation of the Respiratory Burst Oxidase Subunit p47 as Determined by Two-dimensional Phosphopeptide Mapping

1996 • 241 citations

The phosphorylation targets of p47phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesis.

1995 • 184 citations

A possible role for protein phosphorylation in the activation of the respiratory burst in human neutrophils. Evidence from studies with cells from patients with chronic granulomatous disease.

1986 • 168 citations

The cytosolic components of the respiratory burst oxidase exist as a M(r) approximately 240,000 complex that acquires a membrane-binding site during activation of the oxidase in a cell-free system.

1992 • 150 citations

Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558.

1990 • 134 citations

Coregulation of NADPH oxidase activation and phosphorylation of a 48-kD protein(s) by a cytosolic factor defective in autosomal recessive chronic granulomatous disease.

1988 • 93 citations

Kinase-dependent Activation of the Leukocyte NADPH Oxidase in a Cell-free System

1997 • 81 citations

Direct evidence for interaction between COOH-terminal regions of cytochrome b558 subunits and cytosolic 47-kDa protein during activation of an O(2-)-generating system in neutrophils.

1992 • 78 citations

Effects of antagonists of protein phosphatases on superoxide release by neutrophils.

1992 • 67 citations

Restoration of superoxide generation to a chronic granulomatous disease- derived B-cell line by retrovirus mediated gene transfer

1992 • 57 citations

Involvement of protein kinase C in the phosphorylation of 46 kDa proteins which are phosphorylated in parallel with activation of NADPH oxidase in intact guinea-pig polymorphonuclear leukocytes

1986 • 45 citations

Arachidonate activation of the neutrophil NADPH-oxidase. Synergistic effects of protein phosphatase inhibitors compared with protein kinase activators.

1991 • 45 citations

Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils

1993 • 45 citations

Okadaic acid produces changes in phosphorylation and translocation of proteins and in intracellular calcium in human neutrophils. Relationship with the activation of the NADPH oxidase by different stimuli

1992 • 43 citations

The effect of putative protein kinase C inhibitors, K252a and staurosporine, on the human neutrophil respiratory burst activated by both receptor stimulation and post‐receptor mechanisms

1990 • 41 citations

Cell-Free Activation of the Respiratory Burst Oxidase by Protein Kinase C

1995 • 36 citations

Okadaic acid induces both augmentation and inhibition of opsonized zymosan-stimulated superoxide production by differentiated HL-60 cells. Possible involvement of dephosphorylation of a cytosolic 21K protein in respiratory burst

1995 • 26 citations

Translocation of Recombinant p47phox Cytosolic Component of the Phagocyte Oxidase by in Vitro Phosphorylation

1995 • 21 citations

Contrasting effects of calyculin A and okadaic acid on the respiratory burst of human neutrophils

1995 • 19 citations

Naphthalenesulphonamides block neutrophil superoxide production by intact cells and in a cell-free system: is myosin light chain kinase responsible for these effects?

1995 • 13 citations