Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells.

Protein modules and signalling networks

1995 • 2,447 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1994 • 519 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

1991 • 379 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

1989 • 341 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains

1993 • 295 citations

Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.

1994 • 286 citations

Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets.

1994 • 285 citations

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

1993 • 272 citations

Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.

1992 • 265 citations

Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

1990 • 248 citations

Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy

1992 • 211 citations

Activation of neutrophil NADPH oxidase in a cell-free system. Partial purification of components and characterization of the activation process.

1987 • 202 citations

The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells

1995 • 179 citations

Structure and function of the SH3 domain

1994 • 168 citations

An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex.

1994 • 160 citations

Oncogenic activation of tyrosine kinases

1994 • 138 citations

Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558.

1990 • 134 citations

Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.

1994 • 126 citations

Characterization of neutrophil NADPH oxidase factors p47-phox and p67-phox from recombinant baculoviruses.

1991 • 124 citations

A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox.

1994 • 109 citations

156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox.

1994 • 107 citations

Role of p67-phox SH3 domains in assembly of the NADPH oxidase system.

1994 • 106 citations

Mapping the domains of interaction of p40phox with both p47phox and p67phox of the neutrophil oxidase complex using the two-hybrid system.

1995 • 106 citations

Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox

1993 • 101 citations

Peripheral blood progenitors as a target for genetic correction of p47phox-deficient chronic granulomatous disease.

1993 • 85 citations

CD34+ peripheral blood progenitors as a target for genetic correction of the two flavocytochrome b558 defective forms of chronic granulomatous disease

1994 • 83 citations

Mapping the Domains of Interaction of p40 with Both p47 and p67 of the Neutrophil Oxidase Complex Using the Two-hybrid System

1995 • 81 citations

Interactions between the Cytosolic Components p47 and p67 of the Human Neutrophil NADPH Oxidase That Are Not Required for Activation in the Cell-free System

1995 • 78 citations

Evidence for a readily dissociable complex of p47phox and p67phox in cytosol of unstimulated human neutrophils.

1994 • 70 citations

A bicistronic retrovirus vector containing a picornavirus internal ribosome entry site allows for correction of X-linked CGD by selection for MDR1 expression

1996 • 57 citations

Functional reconstitution of the phagocyte NADPH oxidase by transfection of its multiple components in a heterologous system

1995 • 54 citations

Mutation of a phenylalanine conserved in SH3-containing tyrosine kinases activates the transforming ability of c-Abl.

1993 • 37 citations