Essential Requirement of Cytosolic Phospholipase A2for Activation of the H+ Channel in Phagocyte-like Cells

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Single-step separation of red blood cells, granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque

1974 • 735 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase

1993 • 586 citations

A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

1984 • 544 citations

Cytoplasmic pH regulation in thymic lymphocytes by an amiloride-sensitive Na+/H+ antiport.

1984 • 434 citations

Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease

1988 • 401 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

1989 • 341 citations

The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel

1987 • 335 citations

Two Forms of Autosomal Chronic Granulomatous Disease Lack Distinct Neutrophil Cytosol Factors

1988 • 327 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

Transport of H+ and of ionic weak acids and bases

1983 • 271 citations

Essential Requirement of Cytosolic Phospholipase A2for Activation of the Phagocyte NADPH Oxidase

1998 • 199 citations

Internal pH changes associated with the activity of NADPH oxidase of human neutrophils. Further evidence for the presence of an H+ conducting channel

1988 • 178 citations

Induction of the respiratory burst in HL-60 cells. Correlation of function and protein expression.

1990 • 137 citations

Proton conductance of the plasma membrane: properties, regulation, and functional role

1993 • 136 citations

Voltage-activated hydrogen ion currents

1994 • 132 citations

Superoxide generation by the electrogenic NADPH oxidase of human neutrophils is limited by the movement of a compensating charge.

1988 • 132 citations

Activation of Proton Pumping in Human Neutrophils Occurs by Exocytosis of Vesicles Bearing Vacuolar-type H+-ATPases

1996 • 131 citations

Cytoplasmic pH regulation in phorbol ester-activated human neutrophils

1986 • 126 citations

Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins

1993 • 108 citations

The Arachidonate-activable, NADPH Oxidase-associated H+ Channel

1995 • 104 citations

Cytoplasmic pH regulation in normal and abnormal neutrophils. Role of superoxide generation and Na+/H+ exchange.

1986 • 93 citations

Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils.

1991 • 92 citations

Characterization of the amiloride-sensitive Na+-H+ antiport of human neutrophils

1986 • 89 citations

The arachidonate-activatable, NADPH oxidase-associated H+ channel is contained within the multi-membrane-spanning N-terminal region of gp91-phox

1997 • 79 citations

Arachidonic acid stimulates the plasma membrane H+ conductance of macrophages.

1994 • 75 citations

Phorbol 12-myristate 13-acetate activates an electrogenic H+-conducting pathway in the membrane of neutrophils

1992 • 72 citations

The NADPH-oxidase-associated H+ channel is opened by arachidonate

1992 • 69 citations

Na+/H+ exchange activity during phagocytosis in human neutrophils: role of Fcgamma receptors and tyrosine kinases.

1996 • 66 citations

Relative roles of Na⁺/H⁺ exchange and vacuolar‐type H⁺ ATPases in regulating cytoplasmic pH and function in murine peritoneal macrophages

1993 • 64 citations

Phorbol ester-induced changes of cytoplasmic pH in neutrophils: role of exocytosis in Na+-H+ exchange

1985 • 64 citations

Osmotic activation of the Na+H+ antiport in protein kinase C-depleted lymphocytes

1986 • 56 citations

Role of Histidines Identified by Mutagenesis in the NADPH Oxidase-associated H+ Channel

1998 • 56 citations

Abnormal activation of H+ conductance in NADPH oxidase-defective neutrophils.

1993 • 49 citations

Involvement of intracellular pH elevation in the effect of 1,25-dihydroxyvitamin D3 on HL-60 cells.

1989 • 34 citations

Electrogenic H+ pathway contributes to stimulus-induced changes of internal pH and membrane potential in intact neutrophils: role of cytoplasmic phospholipase A2

1997 • 34 citations

Regulation of the electrogenic H+ channel in the plasma membrane of neutrophils: possible role of phospholipase A2, internal and external protons

1993 • 32 citations

Development of a H(+)-selective conductance during granulocytic differentiation of HL-60 cells

1994 • 26 citations

Neutrophil degranulation and phospholipase D activation are enhanced if the Na+/H+ antiport is blocked

1998 • 26 citations

The Membrane Potential of Resting and Activated Neutrophils: Determinants and Significance

1991 • 12 citations