A novel protein kinase target for the lipid second messenger phosphatidic acid

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

NADPH Oxidase: An Update

1999 • 2,134 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

1989 • 905 citations

The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions

1998 • 820 citations

The growing phospholipase A2 superfamily of signal transduction enzymes

1997 • 811 citations

Neutrophils, host defense, and inflammation: a double-edged sword

1994 • 807 citations

The respiratory burst oxidase.

1994 • 608 citations

Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins

1996 • 534 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

Chemoattractant signaling and leukocyte activation

1995 • 510 citations

The Sevenfold Way of PKC Regulation

1998 • 496 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

1989 • 414 citations

Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid

1994 • 410 citations

Phospholipase D: enzymology, mechanisms of regulation, and function

1997 • 405 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

1991 • 379 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.

1996 • 364 citations

Neutrophil Priming: Pathophysiological Consequences and Underlying Mechanisms

1998 • 359 citations

Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes

1976 • 357 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation.

1994 • 332 citations

Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

1994 • 308 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3‐kinases: Binding partners of SH3 domains?

1996 • 304 citations

A Novel Cytosolic Calcium-independent Phospholipase A2 Contains Eight Ankyrin Motifs

1997 • 302 citations

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

1998 • 289 citations

Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.

1994 • 286 citations

Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets.

1994 • 285 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2.

1996 • 271 citations

Neutrophil signal transduction and activation of the respiratory burst

1993 • 262 citations

Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.

1994 • 260 citations

Mammalian Lipid Phosphate Phosphohydrolases

1998 • 253 citations

G-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils.

1992 • 252 citations

Activation of p38 in Stimulated Human Neutrophils: Phosphorylation of the Oxidase Component p47 by p38 and ERK but Not by JNK

1996 • 248 citations

Phosphorylation of the Respiratory Burst Oxidase Subunit p47 as Determined by Two-dimensional Phosphopeptide Mapping

1996 • 241 citations

Cloning and Initial Characterization of a Human Phospholipase D2 (hPLD2)

1998 • 234 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor.

1986 • 215 citations

Regulation of the Neutrophil Respiratory Burst Oxidase

1998 • 209 citations

Biologically active lipids are regulators of Rac.GDI complexation.

1993 • 206 citations

A GTPase-independent Mechanism of p21-activated Kinase Activation

1998 • 204 citations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

1989 • 204 citations

Essential Requirement of Cytosolic Phospholipase A2for Activation of the Phagocyte NADPH Oxidase

1998 • 199 citations

C-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils

1992 • 198 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

The phosphorylation targets of p47phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesis.

1995 • 184 citations

The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters.

1993 • 181 citations

Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane

1994 • 180 citations

Human Type 2 Phosphatidic Acid Phosphohydrolases

1998 • 178 citations

Diacylglycerol – when is it an intracellular messenger?

1998 • 176 citations

Activation of the Leukocyte NADPH Oxidase by Phorbol Ester Requires the Phosphorylation of p47 on Serine 303 or 304

1998 • 173 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes

1988 • 163 citations

Topological Mapping of Neutrophil Cytochrome b Epitopes with Phage-display Libraries

1995 • 162 citations

Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-α and GM-CSF

1998 • 160 citations

Phosphorylation of the Respiratory Burst Oxidase Subunit p67 during Human Neutrophil Activation

1997 • 154 citations

NADPH Oxidase Activity Is Independent of p47

1996 • 154 citations

Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187

1984 • 152 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

The Cytosolic Component p47 Is Not a Sine Qua Non Participant in the Activation of NADPH Oxidase but Is Required for Optimal Superoxide Production

1996 • 150 citations

SIGNAL TRANSDUCTION BY PROTEIN KINASE C IN MAMMALIAN CELLS

1998 • 150 citations

Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: role in activation of reduced nicotinamide adenine dinucleotide oxidase.

1997 • 149 citations

Phosphatidate-dependent protein phosphorylation.

1991 • 149 citations

Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

1994 • 148 citations

Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling Complex

1998 • 147 citations

Association of SH2 Domain Protein Tyrosine Phosphatases with the Epidermal Growth Factor Receptor in Human Tumor Cells

1995 • 145 citations

Activation of p47 , a Cytosolic Subunit of the Leukocyte NADPH Oxidase

1998 • 141 citations

Phosphatidic Acid-mediated Phosphorylation of the NADPH Oxidase Component p47-phox

1997 • 140 citations

Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.

1988 • 138 citations

Rac Binding to p67

1997 • 135 citations

Constitutive activation of protein kinase B and phosphorylation of p47 phox by a membrane-targeted phosphoinositide 3-kinase

1996 • 130 citations

Tumor necrosis factor alpha priming of phospholipase D in human neutrophils

1991 • 129 citations

Characterization of neutrophil NADPH oxidase factors p47-phox and p67-phox from recombinant baculoviruses.

1991 • 124 citations

Characterization of human PLD2 and the analysis of PLD isoform splice variants

1998 • 121 citations

Inhibition of Rap1A Binding to Cytochrome b ₅₅₈ of NADPH Oxidase by Phosphorylation of Rap1A

1991 • 120 citations

Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells.

1996 • 116 citations

Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase.

1992 • 115 citations

Phospholipase D activation by platelet-activating factor, leukotriene B4, and formyl-methionyl-leucyl-phenylalanine in rabbit neutrophils. Phospholipase D activation is involved in enzyme release.

1991 • 115 citations

Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity

1995 • 112 citations

Selective Role for β-Protein Kinase C in Signaling for O⨪2 Generation but Not Degranulation or Adherence in Differentiated HL60 Cells

1998 • 110 citations

The Rac Target NADPH Oxidase p67 Interacts Preferentially with Rac2 Rather Than Rac1

1996 • 110 citations

Propranolol, a phosphatidate phosphohydrolase inhibitor, also inhibits protein kinase C.

1992 • 110 citations

Bacterial phagocytosis activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in human neutrophils

1998 • 109 citations

Function of wild-type or mutant Rac2 and Rap1a GTPases in differentiated HL60 cell NADPH oxidase activation

1995 • 109 citations

Phosphatidohydrolase activity in a solubilized preparation from rat brain particulate fraction

1975 • 108 citations

Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins

1993 • 108 citations

Phospholipase D

1998 • 107 citations

Phospholipase D

1998 • 104 citations

The Cytosolic Activating Factors p47phox and p67phox Have Distinct Roles in the Regulation of Electron Flow in NADPH Oxidase

1995 • 104 citations

Activation of PKN, a Novel 120-kDa Protein Kinase with Leucine Zipper-like Sequences, by Unsaturated Fatty Acids and by Limited Proteolysis

1994 • 101 citations

Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox

1993 • 101 citations

Changes in phosphatidylinositol and phosphatidic acid in stimulated human neutrophils

1983 • 101 citations

Complement C5a activation of phospholipase D in human neutrophils. A major route to the production of phosphatidates and diglycerides.

1990 • 101 citations

Analysis of Activation-induced Conformational Changes in p47 Using Tryptophan Fluorescence Spectroscopy

1997 • 100 citations

Generation of Superoxide by purified and relipidated cytochrome b₅₅₉ in the absence of cytosolic activators

1993 • 99 citations

Activation of the Small GTPase Rap1 in Human Neutrophils

1998 • 98 citations

Phosphatidic acid and diacylglycerol synergize in a cell-free system for activation of NADPH oxidase from human neutrophils.

1993 • 96 citations

Isolation of a Complex of Respiratory Burst Oxidase Components from Resting Neutrophil Cytosol

1994 • 96 citations

Lipid-mediated Regulation of G Protein-coupled Receptor Kinases 2 and 3

1995 • 93 citations

Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors

1995 • 93 citations

Tyrosine-specific protein phosphorylation during activation of human neutrophils

1990 • 91 citations

Cell-free activation of neutrophil NADPH oxidase by a phosphatidic acid-regulated protein kinase.

1995 • 90 citations

Interactions between cytosolic components of the NADPH oxidase: p40phox interacts with both p67phox and p47phox

1996 • 89 citations

Inositol and Phosphoinositides

1985 • 89 citations

Stimulation of phosphatidylinositol 4,5-bisphosphate phospholipase C activity by phosphatidic acid

1989 • 88 citations

The superoxide-generating system of human neutrophils possesses a novel diaphorase activity. Evidence for distinct regulation of electron flow within NADPH oxidase by p67-phox and p47-phox.

1994 • 86 citations

Cryptic Rac-binding and p21 -activated Kinase Phosphorylation Sites of NADPH Oxidase Component p67

1998 • 84 citations

Kinase-dependent Activation of the Leukocyte NADPH Oxidase in a Cell-free System

1997 • 81 citations

A 68-kDa Kinase and NADPH Oxidase Component p67 Are Targets for Cdc42Hs and Rac1 in Neutrophils

1995 • 80 citations

The PC motif : a novel and evolutionarily conserved sequence involved in interaction between p40 ^phox and p67^phox, SH3 domain‐containing cytosolic factors of the phagocyte NADPH oxidase

1998 • 80 citations

Purification and characterization of a third cytosolic component of the superoxide-generating NADPH oxidase of macrophages.

1991 • 78 citations

Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol.

1990 • 78 citations

Protein Kinase Cα Regulates Human Monocyte O·̄2Production and Low Density Lipoprotein Lipid Oxidation

1999 • 71 citations

Purification and characterization of a fatty acid-activated protein kinase (PKN) from rat testis

1995 • 71 citations

Activation of the Leukocyte NADPH Oxidase Subunit p47^phox by Protein Kinase C. A Phosphorylation-Dependent Change in the Conformation of the C-Terminal End of p47^phox

1997 • 71 citations

Syk Activation Is Required for Spreading and H2O2 Release in Adherent Human Neutrophils

1998 • 69 citations

Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation: studies with a staurosporine analogue with improved selectivity for protein kinase C

1993 • 69 citations

SH3-dependent assembly of the phagocyte NADPH oxidase.

1994 • 68 citations

Tyrosine phosphorylation and its possible role in superoxide production by human neutrophils stimulated with FMLP and IgG

1992 • 67 citations

Superoxide production by cytochrome b₅₅₉

1994 • 66 citations

Effect of Inhibitors of Distinct Signaling Pathways on Neutrophil O2− Generation in Response to Tumor Necrosis Factor-α, and Antibodies Against CD18 and CD11a: Evidence for a Common and Unique Pattern of Sensitivity to Wortmannin and Protein Tyrosine

1993 • 66 citations

Electron Transfer Across the O₂^- Generating Flavocytochrome b of Neutrophils. Evidence for a Transition from a Low-Spin State to a High-Spin State of the Heme Iron Component

1996 • 65 citations

Cell signalling by integrins and immunoglobulin receptors in primed neutrophils

1995 • 64 citations

Fc receptor-mediated signal transduction

1994 • 64 citations

Tumor necrosis factor triggers redistribution to a Triton X-100-insoluble, cytoskeletal fraction of β2 integrins, NADPH oxidase components, tyrosine phosphorylated proteins, and the protein tyrosine kinase p58fgr in human neutrophils adherent to fibrinogen

1995 • 63 citations

Selective Activation of Rolipram-Sensitive, cAMP-Specific Phosphodiesterase Isoforms by Phosphatidic Acid

1997 • 63 citations

Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets

1994 • 62 citations

Low-molecular-weight GTP-binding proteins and leukocyte signal transduction

1995 • 61 citations

Phospholipase D-mediated diradylglycerol formation coincides with H2O2 and lactoferrin release in adherent human neutrophils.

1994 • 60 citations

Mutational Analysis of Novel Effector Domains in Rac1 Involved in the Activation of Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase

1998 • 60 citations

The β-Adrenergic Receptor Kinase (GRK2) Is Regulated by Phospholipids

1995 • 59 citations

A novel ecto-phosphatidic acid phosphohydrolase activity mediates activation of neutrophil superoxide generation by exogenous phosphatidic acid.

1993 • 58 citations

Electron transfer in the superoxide-generating NADPH oxidase complex reconstituted in vitro

1997 • 58 citations

Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. Correlation between oxidase activation and phosphatidic acid production.

1992 • 58 citations

Phosphatidic Acid-induced Elevation of Intracellular Ca2+ Is Mediated by RhoA and H2O2in Rat-2 Fibroblasts

1998 • 58 citations

Biochemistry and cell biology of phospholipase D in human neutrophils

1996 • 58 citations

A novel conformationally restricted protein kinase C inhibitor, Ro 31‐8425, inhibits human neutrophil superoxide generation by soluble, particulate and post‐receptor stimuli

1991 • 57 citations

Ras GTPase-activating protein physically associates with mitogenically active phospholipids.

1991 • 56 citations

Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by coomassie blue staining and densitometry

1989 • 56 citations

Trp-Lys-Tyr-Met-Val-D-Met stimulates superoxide generation and killing of Staphylococcus aureus via phospholipase D activation in human monocytes

1999 • 55 citations

Phosphorylation of the subunits of cytochrome b-245 upon triggering of the respiratory burst of human neutrophils and macrophages

1988 • 53 citations

Topological organization of the cytosolic activating complex of the superoxide-generating NADPH-oxidase. Pinpointing the sites of interaction between p47phox, p67phox and p40phox using the two-hybrid system

1996 • 51 citations

Divergent effects of propranolol on neutrophil superoxide release: Involvement of phosphatidic acid and diacylglycerol as second messengers

1991 • 49 citations

Role of the rac1 p21‐GDP‐dissociation inhibitor for rho heterodimer in the activation of the superoxide‐forming NADPH oxidase of macrophages

1993 • 49 citations

The 40‐kDa Component of the Phagocyte NADPH Oxidase (p40phox) is Phosphorylated during Activation in Differentiated HL60 Cells

1997 • 49 citations

Phosphatidic Acid Directly Activates Endothelial Cell Protein Kinase C

1993 • 47 citations

A cardiolipin-activated protein kinase from rat liver structurally distinct from the protein kinases C.

1994 • 46 citations

Activation of phospholipase D by interleukin-8 in human neutrophils

1994 • 46 citations

Arachidonic acid increases the activity of the assembled NADPH oxidase in cytoplasmic membranes and endosomes

1993 • 46 citations

Identification of multiple, novel, protein kinase C‐related gene products

1994 • 45 citations

The temporal relationship between phospholipase activation, diradylglycerol formation and superoxide production in the human neutrophil

1990 • 45 citations

Mutagenesis of an Arginine- and Lysine-rich Domain in the gp91 Subunit of the Phagocyte NADPH-oxidase Flavocytochromeb 558

1999 • 45 citations

Phorbol ester-induced priming of superoxide generation by phosphatidic acid-stimulated neutrophils and granule-free neutrophil cytoplasts

1995 • 45 citations

The major phosphorylation site of the NADPH oxidase component p67phox is Thr233

1999 • 44 citations

Inhibition by HAJ11 of respiratory burst in neutrophils and the involvement of protein tyrosine phosphorylation and phospholipase D activation

1997 • 44 citations

Phospholipases and activation of the NADPH oxidase

1993 • 43 citations

Intercellular Signaling by Lysophosphatidate Recent Developments

1998 • 42 citations

Dermaseptin, a Peptide Antibiotic, Stimulates Microbicidal Activities of Polymorphonuclear Leukocytes

1998 • 42 citations

Phosphatidic acid elicits calcium mobilization and actin polymerization through a tyrosine kinase-dependent process in human neutrophils: a mechanism for induction of chemotaxis

1997 • 41 citations

Molecular and biochemical characterization of a recombinant human PKC-δ family member

1993 • 39 citations

Expression, purification and characterization of the ubiquitous protein kinase C-related kinase 1

1995 • 39 citations

Glucose suppresses superoxide generation in normal neutrophils: interference in phospholipase D activation

1993 • 38 citations

Inositol and Phosphoinositides: Metabolism and Regulation

1985 • 37 citations

Isolation and Characterization of a Structural Homologue of Human PRK2 from Rat Liver

1997 • 37 citations

Conformational changes of the leukocyte NADPH oxidase subunit p47phox during activation studied through its intrinsic fluorescence

1998 • 37 citations

The 47-kDa protein involved in the NADPH:O2 oxidoreductase activity of human neutrophils is phosphorylated by cyclic AMP-dependent protein kinase without induction of a respiratory burst

1988 • 36 citations

Fluoride activates diradylglycerol and Superoxide generation in human neutrophils via PLD/PA phosphohydrolase-dependent and -independent pathways

1990 • 35 citations

Crystal‐induced neutrophil activation. II. evidence for the activation of a phosphatidylcholine‐specific phospholipase D

1993 • 35 citations

Phosphatidic acid phosphatase from mammalian tissues: discovery of channel-like proteins with unexpected functions

1997 • 34 citations

Phosphatidic acid stimulates the rolipram-sensitive cyclic nucleotide phosphodiesterase from rat thymocytes

1993 • 34 citations

Source and role of diacylglycerol formed during phagocytosis of opsonized yeast particles and associated respiratory burst in human neutrophils

1991 • 33 citations

Stimulation of Primed Neutrophils by Soluble Immune Complexes: Priming Leads to Enhanced Intracellular Ca2+Elevations, Activation of Phospholipase D, and Activation of the NADPH Oxidase

1998 • 33 citations

Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2

1997 • 33 citations

The neutrophil respiratory burst mechanism.

1992 • 30 citations

Regulation of secretory type-II phospholipase A2 and of lysophosphatidic acid synthesis

1998 • 28 citations

Regulation of interleukin‐2 responses by phosphatidic acid

1992 • 27 citations

[14] GTPase-activating protein activity of n(α1)-chimaerin and effect of lipids

1995 • 25 citations

Enhancement of phospholipase A₂ activation by phosphatidic acid endogenously formed through phospholipase D action in rat peritoneal mast cell

1993 • 25 citations

Fluorescent Labeling of the Leukocyte NADPH Oxidase Subunit p47phox: Evidence for Amphiphile-Induced Conformational Changes

1998 • 24 citations

Differential effects of fatty acid and phosholipid activators on the catalytic activities of a structurally novel protein kinase from rat liver

1994 • 24 citations

Priming of Phosphatidic Acid Production by Staurosporine in f-Met-Leu-Phe-Stimulated Human Neutrophils—Correlation with Respiratory Burst

1998 • 22 citations

Tyrosine phosphorylation of 100–115 kDa proteins by phosphatidic acid generated via phospholipase D activation in HL60 granulocytes

1997 • 22 citations

Phosphatidic Acid‐Dependent Phosphorylation of a 29‐kDa Protein by Protein Kinase Cα in Bovine Brain Cytosol

1998 • 21 citations

Translocation of guinea pig p40-phox during activation of NADPH oxidase

1996 • 20 citations

Arachidonic acid liberation induced by phosphatidic acid endogenously generated from membrane phospholipids in rabbit platelets

1994 • 20 citations

Phagocyte NADPH Oxidase p67-phoxPossesses a Novel Carboxylterminal Binding Site for the GTPases Rac2 and Cdc42

1998 • 19 citations

Activation of a cyclic nucleotide phosphodiesterase 4 (PDE4) from rat thymocytes by phosphatidic acid

1996 • 17 citations

Calcium-Independent Activation of Protein Kinase C by the Dianionic Form of Phosphatidic Acid

1993 • 17 citations

Relationships between phosphatidic acid and cyclic nucleotide phosphodiesterases in activated human blood mononuclear cells

1999 • 17 citations

Characterization and partial purification of a novel neutrophil membrane-associated kinase capable of phosphorylating the respiratory burst component p47phox.

1999 • 15 citations

Involvement of Several Protein Kinases in the Phosphorylation of p47-phox

1996 • 15 citations

Products of Sphingolipid Catabolism Block Activation of the p21-Activated Protein Kinases in Neutrophils

1998 • 14 citations

Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D

1991 • 14 citations

Phosphatidic Acid-Induced Translocation of Cytosolic Components in a Cell-Free System of NADPH Oxidase: Mechanism of Activation and Effect of Diacylglycerol

1996 • 12 citations

Exogenous phosphatidic acid with saturated short-chain fatty acyl groups induces superoxide anion release from guinea pig peritoneal polymorphonuclear leukocytes by three different mechanisms

1997 • 12 citations

Leukotriene B₄ stimulation of an early elevation of phosphatidic acid mass in human neutrophils

1995 • 12 citations

Activation of the leukocyte NADPH oxidase in a cell-free system: phosphorylation vs. amphiphiles.

1998 • 10 citations

Superoxide anion production and phospholipase D-mediated generation of diacylglycerol are subnormal after N-formyl-methionyl-leucyl-phenylalanine stimulation of polymorphonuclear granulocytes in polycythemia vera.

1993 • 9 citations

Relationship of phospholipase C- and phospholipase D-mediated phospholipid remodeling pathways to respiratory burst activation in human neutrophils stimulated by Candida albicans hyphae

1995 • 8 citations

Characterization and partial purification of a novel neutrophil membrane-associated kinase capable of phosphorylating the respiratory burst component p47phox

1999 • 8 citations

Loss of Phosphatidylinositol and Gain in Phosphatidate in Neutrophils Stimulated with Fmet-Leu-Phe

1985 • 2 citations