GSK3: a SHAGGY frog story

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling

1993 • 877 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

1994 • 647 citations

Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.

1993 • 616 citations

Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity.

1995 • 594 citations

Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation

1994 • 578 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

1995 • 492 citations

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

1994 • 476 citations

wingless signaling acts through zeste-white 3, the drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate

1992 • 425 citations

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

1993 • 399 citations

Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.

1992 • 394 citations

Glycogen synthase kinase-3: functions in oncogenesis and development

1992 • 379 citations

Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos

1993 • 366 citations

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase.

1995 • 358 citations

A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.

1994 • 278 citations

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

1995 • 233 citations

The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitro

1994 • 231 citations

Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo.

1994 • 224 citations

Glycogen synthase kinase 3 regulates cell fate in dictyostelium

1995 • 221 citations

Inactivation of Glycogen Synthase Kinase-3 by Epidermal Growth Factor Is Mediated by Mitogen-activated Protein Kinase/p90 Ribosomal Protein S6 Kinase Signaling Pathway in NIH/3T3 Cells

1995 • 216 citations

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1994 • 204 citations

Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch

1993 • 203 citations

Cell adhesion and signal transduction: the Armadillo connection

1995 • 200 citations

Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled

1995 • 185 citations

The genetic basis of patterned baldness in Drosophila

1994 • 182 citations

Notch is required for wingless signaling in the epidermis of Drosophila

1994 • 179 citations

The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells

1994 • 145 citations

A common denominator linking glycogen metabolism, nuclear oncogenes and development

1991 • 138 citations

Identification of multifunctional ATP-citrate lyase kinase as the α-isoform of glycogen synthase kinase-3

1992 • 113 citations

Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells

1995 • 110 citations

Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase

1995 • 100 citations

MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3.

1994 • 81 citations

Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila.

1993 • 70 citations

Isoform differences in substrate recognition by glycogen synthase kinases 3.alpha. and 3.beta. in the phosphorylation of phosphatase inhibitor 2

1994 • 69 citations

Arabidopsis homologs of the shaggy and GSK-3 protein kinases: molecular cloning and functional expression in Escherichia coli

1994 • 58 citations

Baculovirus‐mediated expression and characterisation of rat glycogen synthase kinase‐3β, the mammalian homologue of the Drosophila melanogaster zeste‐white 3^sgg, homeotic gene product

1992 • 56 citations

Schizosaccharomyces pombe skp1⁺ Encodes a Protein Kinase Related to Mammalian Glycogen Synthase Kinase 3 and Complements a cdc14 Cytokinesis Mutant

1996 • 54 citations

Okadaic acid, a serine/threonine phosphatase inhibitor, induces tyrosine dephosphorylation/inactivation of protein kinase FA/GSK-3 alpha in A431 cells.

1994 • 38 citations

Inhibition of Glycogen Synthase Kinase-3 by Insulin in Cultured Human Skeletal Muscle Myoblasts

1995 • 36 citations