Serine/threonine kinases in the nervous system

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

1990 • 630 citations

In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain

1990 • 566 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Identification of intracellular receptor proteins for activated protein kinase C.

1991 • 505 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem

1989 • 411 citations

Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs

1989 • 397 citations

Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

1990 • 298 citations

Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation

1989 • 293 citations

Calcium/calmodulin-dependent protein kinase II increases glutamate and noradrenaline release from synaptosomes

1990 • 284 citations

The Synapsins

1990 • 268 citations

Feasibility of long-term storage of graded information by the Ca2+/calmodulin-dependent protein kinase molecules of the postsynaptic density.

1988 • 261 citations

Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain

1989 • 261 citations

Phosphorylation-dependent subcellular translocation of a Ca2+/calmodulin-dependent protein kinase produces an autonomous enzyme in Aplysia neurons.

1985 • 261 citations

A protein kinase C isozyme is translocated to cytoskeletal elements on activation.

1990 • 257 citations

Expression, purification, and characterization of protein kinase C-epsilon.

1990 • 231 citations

Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40.

1990 • 224 citations

Calcium/Calmodulin-Dependent Protein Kinase II

1990 • 182 citations

cAMP-dependent protein kinase and the disruption of learning in transgenic flies

1991 • 181 citations

Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death.

1990 • 179 citations

Autophosphorylation of Ca2+/calmodulin-dependent protein kinase II. Effects on total and Ca2+-independent activities and kinetic parameters.

1987 • 174 citations

Activation of type II calcium/calmodulin-dependent protein kinase by Ca2+/calmodulin is inhibited by autophosphorylation of threonine within the calmodulin-binding domain.

1990 • 171 citations

Studies of the Regulatory Mechanism of Ca2+/Calmodulin-dependent protein kinase II

1989 • 165 citations

Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells.

1990 • 165 citations

Autophosphorylation of Protein Kinase C at Three Separated Regions of Its Primary Sequence

1990 • 151 citations

A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation.

1990 • 145 citations

Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor

1990 • 136 citations

Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation ofAplysia sensory neurons

1989 • 131 citations

Multifunctional calcium/calmodulin-dependent protein kinase made calcium-independent for functional studies

1990 • 127 citations

Protein kinase C heterogeneity in GH4C1 rat pituitary cells. Characterization of a Ca2(+)-independent phorbol ester receptor.

1990 • 126 citations

Effects of synapsin I and calcium/calmodulin-dependent protein kinase II on spontaneous neurotransmitter release in the squid giant synapse.

1990 • 122 citations

Expression of the alpha, beta II, and gamma protein kinase C isozymes in the baculovirus-insect cell expression system. Purification and characterization of the individual isoforms.

1990 • 120 citations

Thrombin stimulates the activities of multiple previously unidentified protein kinases in platelets

1989 • 112 citations

Ca2+/calmodulin-dependent protein kinase II: localization in the interphase nucleus and the mitotic apparatus of mammalian cells.

1990 • 109 citations

Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotides.

1990 • 106 citations

Ca2+/calmodulin kinase is activated by the phosphatidylinositol signaling pathway and becomes Ca2(+)-independent in PC12 cells.

1990 • 98 citations

Differential activation of protein kinase C alpha is associated with arachidonate release in Madin-Darby canine kidney cells.

1990 • 85 citations

Induction of exocytosis in permeabilized pituitary cells by alpha- and beta-type protein kinase C.

1989 • 78 citations

Protein synthesis during acquisition of long-term facilitation is needed for the persistent loss of regulatory subunits of the Aplysia cAMP-dependent protein kinase.

1990 • 76 citations

Regulation of CI− channels by multifunctional CaM kinase

1991 • 68 citations

Protein Kinase C and Regulation of the Local Competence of Xenopus Ectoderm

1991 • 66 citations

ζ-Related protein kinase C in nuclei of nerve cells

1990 • 46 citations

Phosphorylation of microtubule-associated protein-2 in GH3 cells. Regulation by cAMP and by calcium.

1991 • 31 citations

Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells

1991 • 16 citations

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