Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Protein modules and signalling networks

1995 • 2,447 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

1994 • 715 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Fluorescence ratio imaging of cyclic AMP in single cells

1991 • 686 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Association of Protein Kinase A and Protein Phosphatase 2B with a Common Anchoring Protein

1995 • 615 citations

Identification of intracellular receptor proteins for activated protein kinase C.

1991 • 505 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif

1991 • 437 citations

Binding of 14-3-3 Proteins to the Protein Kinase Raf and Effects on Its Activation

1994 • 415 citations

Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons

1994 • 371 citations

Activation of Raf-1 by 14-3-3 proteins

1994 • 370 citations

Localization of Protein Kinase C Isozymes in Cardiac Myocytes

1994 • 342 citations

Molecular characterization of the cAMP-dependent protein kinase bound to microtubule-associated protein 2.

1982 • 334 citations

Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.

1992 • 327 citations

Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes

1987 • 321 citations

Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus.

1985 • 317 citations

Stimulatory Effects of Yeast and Mammalian 14-3-3 Proteins on the Raf Protein Kinase

1994 • 299 citations

PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system.

1995 • 297 citations

Protein kinase C — a family affair

1989 • 289 citations

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex.

1994 • 261 citations

A protein kinase C isozyme is translocated to cytoskeletal elements on activation.

1990 • 257 citations

Selective translocation of beta II-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells.

1991 • 251 citations

Association of the Protein Kinases c-Bcr and Bcr-Abl with Proteins of the 14-3-3 Family

1994 • 233 citations

Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme

1991 • 212 citations

The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras

1994 • 202 citations

An autoregulatory region in protein kinase C: the pseudoanchoring site.

1995 • 199 citations

Heterogeneous distribution of the cAMP receptor protein RII in the nervous system: evidence for its intracellular accumulation on microtubules, microtubule-organizing centers, and in the area of the Golgi complex.

1986 • 197 citations

Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia.

1990 • 195 citations

A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.

1994 • 185 citations

High affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II-B

1989 • 184 citations

Type II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein kinase.

1990 • 183 citations

Association of Polyomavirus Middle Tumor Antigen with 14-3-3 Proteins

1994 • 162 citations

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

1986 • 154 citations

Factors influencing chelator-stable, detergent-extractable, phorbol diester-induced membrane association of protein kinase C. Differences between Ca2+-induced and phorbol ester-stabilized membrane bindings of protein kinase C.

1986 • 144 citations

Characterization of the phosphorylation sites in the chicken and bovine myristoylated alanine-rich C kinase substrate protein, a prominent cellular substrate for protein kinase C

1989 • 136 citations

The RII subunit of camp-dependent protein kinase binds to a common amino-terminal domain in microtubule-associated proteins 2A, 2B, and 2C

1989 • 130 citations

Agonists and antagonists of protein kinase C function, derived from its binding proteins.

1994 • 125 citations

A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for .beta.-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase

1986 • 125 citations

Interaction cloning of protein kinase C substrates.

1993 • 122 citations

cAMP signaling in neurons: patterns of neuronal expression and intracellular localization for a novel protein, AKAP 150, that anchors the regulatory subunit of cAMP-dependent protein kinase II beta.

1992 • 121 citations

Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation

1992 • 107 citations

Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta.

1992 • 102 citations

Protein kinase C is present in human sperm: possible role in flagellar motility.

1990 • 101 citations

Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins.

1994 • 99 citations

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

1993 • 98 citations

Protein kinase C and phosphatidylserine bind to Mr 110,000/115,000 polypeptides enriched in cytoskeletal and postsynaptic density preparations.

1986 • 95 citations

Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus.

1994 • 95 citations

Identification and Characterization of .alpha.-Protein Kinase C Binding Proteins in Normal and Transformed REF52 Cells

1994 • 91 citations

Immunocytochemical evidence for phorbol ester-induced protein kinase C translocation in HL60 cells

1986 • 90 citations

Enzymatic characteristics of the c-Raf-1 proteinkinase.

1994 • 87 citations

Mechanism of beta-adrenergic receptor kinase activation by G proteins

1993 • 83 citations

Activation by G protein beta gamma subunits of beta-adrenergic and muscarinic receptor kinase.

1993 • 83 citations

Activation of α-Protein Kinase C Leads to Association with Detergent-Insoluble Components of GH₄C₁Cells

1990 • 79 citations

Protein kinase C is localized in focal contacts of normal but not transformed fibroblasts

1990 • 70 citations

Isolation and characterization of protein kinase C from Y-1 adrenal cell cytoskeleton.

1989 • 63 citations

Expression of a kinase anchor protein 75 depletes type II cAMP-dependent protein kinases from the cytoplasm and sequesters the kinases in a particulate pool.

1993 • 59 citations

Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme

1992 • 55 citations

Association of the β isoform of protein kinase C with vimentin filaments

1992 • 55 citations

Protein kinase C; current concepts and future perspectives

1993 • 54 citations

Presence of a beta II protein kinase C-selective nuclear membrane activation factor in human leukemia cells.

1994 • 51 citations

The sites at which brain microtubule-associated protein 2 is phosphorylated in vivo differ from those accessible to cAMP-dependent kinase in vitro.

1985 • 37 citations

Protein kinase C binding to isolated nuclei and its activation by a Ca2+phospholipid-independent mechanism

1987 • 32 citations

Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells.

1994 • 23 citations

Translocation of protein kinase C to a Triton-insoluble sub-cellular compartment induced by the lipophilic gold compound auranofin

1988 • 22 citations

Discrepancy of protein kinase C translocation and platelet aggregation—Immunocytobiochemical evidence

1990 • 17 citations

Protein kinase C in mouse kidney: subcellular distribution and endogenous substrates

1988 • 17 citations