Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Protein kinase recognition sequence motifs

1990 • 1,014 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

1984 • 852 citations

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

1977 • 834 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

Neurotransmitter regulation of neuronal outgrowth, plasticity and survival

1989 • 733 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

Tau protein function in living cells.

1986 • 727 citations

The Primary Structure and Heterogeneity of Tau Protein from Mouse Brain

1988 • 671 citations

Developmentally regulated expression of specific tau sequences

1989 • 589 citations

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

1988 • 557 citations

Neurotransmitters in the regulation of neuronal cytoarchitecture

1988 • 525 citations

Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1

1986 • 504 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Tau Consists of a Set of Proteins with Repeated C-Terminal Microtubule-Binding Domains and Variable N-Terminal Domains

1989 • 478 citations

Microtubule-Associated Protein MAP2 Shares a Microtubule Binding Motif with Tau Protein

1988 • 476 citations

The microtubule binding domain of tau protein

1989 • 472 citations

Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase. Relationship of Ca2+-binding, conformational changes, and phosphodiesterase activity

1977 • 459 citations

Phosphorylation determines two distinct species of tau in the central nervous system

1987 • 405 citations

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.

1989 • 354 citations

One of the Antigenic Determinants of Paired Helical Filaments Is Related to Tau Protein1

1986 • 336 citations

Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies

1991 • 327 citations

Specific Chemical Cleavage in High Yield at the Amino Peptide Bonds of Cysteine and Cystine Residues

1973 • 325 citations

Fractionation of Brain Microtubule‐Associated Proteins

1978 • 310 citations

Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family.

1989 • 306 citations

Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

1990 • 298 citations

Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids.

1987 • 264 citations

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.

1989 • 255 citations

Phosphorylation of microtubule-associated proteins by a Ca2+/calmodulin-dependent protein kinase.

1984 • 213 citations

Differential Localization of MAP‐2 and Tau in Mammalian Neurons in Situa

1986 • 208 citations

Ca2+-dependent hydrophobic-interaction chromatography. Isolation of a novel Ca2+-binding protein and protein kinase C from bovine brain

1984 • 202 citations

Ca²⁺, Calmodulin‐Dependent Regulation of Microtubule Formation via Phosphorylation of Microtubule‐Associated Protein 2, τ Factor, and Tubulin, and Comparison with the Cyclic AMP‐Dependent Phosphorylation

1985 • 183 citations

Ca²⁺– and Calmodulin‐Dependent Phosphorylation of Microtubule‐Associated Protein 2 and t Factor, and Inhibition of Microtubule Assembly

1983 • 180 citations

Two Separate 18-Amino Acid Domains of Tau Promote the Polymerization of Tubulin

1989 • 167 citations

Molecular Structure and Function of Microtubule-Associated Proteins

1991 • 166 citations

Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes.

1984 • 164 citations

The tubulin-binding sequence of brain microtubule-associated proteins, tau and MAP-2, is also involved in actin binding

1990 • 137 citations

Ontogenetic changes in the cyclic adenosine 3',5'-monophosphate- stimulatable phosphorylation of cat visual cortex proteins, particularly of microtubule-associated protein 2 (MAP 2): effects of normal and dark rearing and of the exposure to light

1985 • 132 citations

Localization of the tubulin binding site for tau protein

1985 • 129 citations

Differential interaction of synthetic peptides from the carboxyl-terminal regulatory domain of tubulin with microtubule-associated proteins.

1988 • 120 citations

Developmental Changes in Calmodulin‐Kinase II Activity at Brain Synaptic Junctions: Alterations in Holoenzyme Composition

1987 • 111 citations

The microtubule-binding fragment of microtubule-associated protein-2: location of the protease-accessible site and identification of an assembly-promoting peptide.

1989 • 98 citations

Calcium/phospholipid-dependent kinase recognizes sites in microtubule-associated protein 2 which are phosphorylated in living brain and are not accessible to other kinases.

1986 • 95 citations

Electron microscopic localization of γ- and βII-subspecies of protein kinase C in rat hippocampus

1990 • 93 citations

Separation of the different microtubule-associated tau protein species from bovine brain and their mode II phosphorylation by Ca2+/phospholipid-dependent protein kinase C.

1987 • 87 citations

Phosphorylation of Tau proteins: a major event during the process of neurofibrillary degeneration. A comparative study between Alzheimer's disease and Down's syndrome

1990 • 83 citations

A Novel Tubulin-Dependent Protein Kinase Forming a Paired Helical Filament Epitope on Tau

1988 • 80 citations

Protein‐kinase‐C‐catalyzed phosphorylation of the microtubule‐binding domain of microtubule‐associated protein 2 inhibits its ability to induce tubulin polymerization

1988 • 78 citations

Tau protein and Alzheimer's disease

1990 • 78 citations

Protein kinase C phosphorylates tau and induces its functional alterations

1987 • 78 citations

Structure and elasticity of microtubule-associated protein tau

1988 • 72 citations

Phosphorylation of Microtubule Proteins in Rat Brain at Different Developmental Stages: Comparison with That Found in Neuronal Cultures

1990 • 72 citations

A discrete repeated sequence defines a tubulin binding domain on microtubule-associated protein tau

1989 • 67 citations

Protein structure: The primary substrate for memory

1990 • 49 citations

Multisite phosphorylation of τ proteins from rat brain

1983 • 44 citations

Peptides corresponding to the second repeated sequence in MAP-2 inhibit binding of microtubule-associated proteins to microtubules

1990 • 42 citations

Localization of the Phosphorylation Sites for Different Kinases in the Microtubule‐Associated Protein MAP₂

1987 • 38 citations

A modified form of microtubule-associated tau protein is the main component of paired helical filaments

1988 • 38 citations

[14] Preparation of fluorescent labeled calmodulins

1983 • 21 citations

An improved purification procedure and properties of casein kinase II from brain

1988 • 17 citations

Differential phosphorylation of microtubule proteins by ATP and GTP

1988 • 11 citations