Protein kinase C isoenzymes: divergence in signal transduction?
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References (218)
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1990 • 211 citations
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1990 • 197 citations
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Selective activation of the γ‐subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites
1989 • 188 citations
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1990 • 183 citations
Autophosphorylation of rat brain Ca2+-activated and phospholipid-dependent protein kinase.
1986 • 183 citations
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1990 • 179 citations
Activation of the PKC‐isotypes α, β1, γ, δ, and ε by phorbol esters of different biological activities
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1987 • 168 citations
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1987 • 168 citations
Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C.
1988 • 166 citations
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1989 • 160 citations
Expression of four protein kinase C isoforms in rat fibroblasts. Distinct subcellular distribution and regulation by calcium and phorbol esters.
1992 • 160 citations
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1987 • 156 citations
Raf-1: A kinase currently without a cause but not lacking in effects
1991 • 155 citations
Expression of Antisense RNA against Initiation Factor eIF-4E mRNA in HeLa Cells Results in Lengthened Cell Division Times, Diminished Translation Rates, and Reduced Levels of Both eIF-4E and the p220 Component of eIF-4F
1991 • 151 citations
Autophosphorylation of Protein Kinase C at Three Separated Regions of Its Primary Sequence
1990 • 151 citations
T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway.
1990 • 147 citations
A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation.
1990 • 145 citations
Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation
1990 • 144 citations
Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific.
1991 • 142 citations
Characterization of the phosphorylation sites in the chicken and bovine myristoylated alanine-rich C kinase substrate protein, a prominent cellular substrate for protein kinase C
1989 • 136 citations
Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor
1990 • 136 citations
Nuclear protein phosphorylation and growth control
1992 • 135 citations
Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC
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The regulatory domain of protein kinase C coordinates four atoms of zinc.
1992 • 129 citations
Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage.
1991 • 129 citations
Chemically induced murine erythroleukemic differentiation
1980 • 128 citations
Protein kinase C heterogeneity in GH4C1 rat pituitary cells. Characterization of a Ca2(+)-independent phorbol ester receptor.
1990 • 126 citations
A dictionary of transcription control sequences
1990 • 124 citations
Protein kinase C activation by phorbol esters: do cysteine-rich regions and pseudosubstrate motifs play a role?
1991 • 124 citations
Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts
1988 • 122 citations
EGF induces biphasic S6 kinase activation: Late phase is protein kinase C-dependent and contributes to mitogenicity
1989 • 122 citations
Protein kinase C group B members PKC-δ, -ɛ, -ζ and PKC-L(η). Comparison of properties of recombinant proteins in vitro and in vivo
1992 • 121 citations
Expression of the alpha, beta II, and gamma protein kinase C isozymes in the baculovirus-insect cell expression system. Purification and characterization of the individual isoforms.
1990 • 120 citations
A mutant protein kinase C that can transform fibroblasts
1989 • 119 citations
Possible involvement of RAS-encoded proteins in glucose-induced inositolphospholipid turnover in Saccharomyces cerevisiae.
1986 • 118 citations
Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis.
1990 • 117 citations
High Cooperativity, Specificity, and Multiplicity in the Protein Kinase C-Lipid Interaction
1989 • 116 citations
Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway.
1990 • 113 citations
Rat liver nuclei protein kinase C is the isozyme type II.
1990 • 112 citations
Protein kinase C isozymes have distinct roles in neural induction and competence in Xenopus
1992 • 110 citations
Distinct mechanisms of regulation of protein kinase C epsilon by hormones and phorbol diesters.
1991 • 107 citations
Structure and properties of a ubiquitously expressed protein kinase C, nPKCδ
1991 • 105 citations
Deletion of the regulatory domain of protein kinase C alpha exposes regions in the hinge and catalytic domains that mediate nuclear targeting.
1992 • 104 citations
Studies on the phosphorylation of protein kinase C-α
1992 • 103 citations
Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation
1992 • 102 citations
A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester.
1989 • 102 citations
Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation.
1987 • 101 citations
Lamin B is rapidly phosphorylated in lymphocytes after activation of protein kinase C.
1988 • 101 citations
Activation of resting human T cells requires prolonged stimulation of protein kinase C.
1990 • 99 citations
Primary structures of human protein kinase C βI and βII differ only in their C‐terminal sequences
1987 • 97 citations
Purified I kappa B-beta is inactivated upon dephosphorylation.
1992 • 97 citations
The mechanism of activation of protein kinase C: a biophysical perspective
1992 • 94 citations
Complete Activation of Protein Kinase C by an Antipeptide Antibody Directed against the Pseudosubstrate Prototope
1989 • 94 citations
Expression and characterization of protein kinase C‐δ
1991 • 94 citations
Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells.
1991 • 89 citations
Overexpression of protein kinase C beta 1 enhances phospholipase D activity and diacylglycerol formation in phorbol ester-stimulated rat fibroblasts.
1991 • 87 citations
Purification and characterization of a calcium-unresponsive, phorbol ester/phospholipid-activated protein kinase from porcine spleen.
1990 • 85 citations
Nucleotide sequences of cDNAs for α and γ subspecies of rat brain protein kinase C
1988 • 85 citations
Mouse protein kinase C-.delta., the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein
1991 • 85 citations
Mechanism of protein kinase C activation by phosphatidylinositol 4,5-bisphosphate
1991 • 84 citations
Protein kinase C autophosphorylates by an intrapeptide reaction.
1987 • 83 citations
Alternative Splicing Increases the Diversity of the Human Protein Kinase C Family
1987 • 83 citations
Phosphorylation of eIF-4F by protein kinase C or multipotential S6 kinase stimulates protein synthesis at initiation.
1991 • 83 citations
Constitutive activity of membrane-inserted protein kinase C
1988 • 83 citations
A fourth type of rabbit protein kinase C
1988 • 80 citations
Purification and characterization of protein kinase C .epsilon. from rabbit brain
1992 • 77 citations
Differential expression of protein kinase C isozymes and erythroleukemia cell differentiation
1989 • 77 citations
Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells.
1992 • 76 citations
Different translocation of three distinct PKC isoforms with tumor-promoting phorbol ester in human platelets
1991 • 76 citations
Overexpression of protein kinase C alpha-subtype in Swiss/3T3 fibroblasts causes loss of both high and low affinity receptor numbers for epidermal growth factor.
1990 • 76 citations
Conversion of protein kinase C from a Ca2+-dependent to an independent form of phorbol ester-binding protein by digestion with trypsim
1986 • 74 citations
The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus.
1992 • 74 citations
Expression and partial characterization of rat protein kinase C‐δ and protein kinase C‐ξ in insect cells using recombinant baculovirus
1992 • 73 citations
Temporal changes in intracellular distribution of protein kinase C during differentiation of human leukemia HL60 cells induced by phorbol ester
1988 • 69 citations
Failure of wild-type or a mutant form of protein kinase C-α to transform fibroblasts
1991 • 68 citations
The phosphorylation of protein kinase C as a potential measure of activation
1989 • 68 citations
Immunocharacterization of δ‐ and ζ‐isoenzymes of protein kinase C in rat renal mesangial cells
1992 • 67 citations
Protein kinase C during differentiation of human promyelocytic leukemia cell line, HL‐60
1990 • 67 citations
Protein kinase C pseudosubstrate prototope: Structure-function relationships
1990 • 66 citations
Proteolytic activation of protein kinase C‐ɛ
1990 • 65 citations
Disturbances in growth control and gene expression in a C3H/10T1/2 cell line that stably overproduces protein kinase C.
1989 • 64 citations
Sequence of human protein kinase C α
1990 • 64 citations
Possible role of Ca2+-independent protein kinase C isozyme, nPKCɛ, in thyrotropin- releasing hormone-stimulated signal transduction: Differential down-regulation of nPKCɛ in GH4C1 cells
1990 • 63 citations
Cell type-specific expression of the genes for the protein kinase C family: Down regulation of mRNAs for PKCα and nPKCε upon in vitro differentiation of a mouse neuroblastoma cell line Neuro 2a
1989 • 62 citations
The leucine zipper of c-Myc is required for full inhibition of erythroleukemia differentiation.
1990 • 61 citations
Characterization and differential expression of protein kinase C isoforms in PC12 cells Differentiation parallels an increase in PKC beta11
1992 • 60 citations
Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
1992 • 58 citations
A New Member of the Protein Kinase C Family, nPKCθ, Predominantly Expressed in Skeletal Muscle
1992 • 57 citations
A synthetic peptide of the pseudosubstrate domain of protein kinase C blocks cytoplasmic alkalinization during activation of the sea urchin egg
1990 • 56 citations
N-myc disrupts protein kinase C-mediated signal transduction in neuroblastoma.
1991 • 56 citations
The regulatory domain of protein kinase C-ε restricts the catalytic-domain-specificity
1991 • 53 citations
Protein kinase C
1992 • 53 citations
Identification of the proteolytically activated form of protein kinase C in stimulated human neutrophils.
1990 • 53 citations
Intracellular delivery of protein kinase C‐α or ε isoform‐specific antibodies promotes acquisition of a morphologically differentiated phenotype in neuroblastoma cells
1992 • 50 citations
Expression of a functional protein kinase C-γ using a baculovirus vector: Purification and characterisation of a single protein kinase C iso-enzyme
1989 • 47 citations
Heterogeneity of protein kinase C expression and regulation in T lymphocytes
1990 • 46 citations
Isolation and Characterization of PKC-L, A New Member of the Protein Kinase C-Related Gene Family Specifically Expressed in Lung, Skin, and Heart
1991 • 44 citations
Transient shift of diacylglycerol and inositol lipids induced by interferon in Daudi cells
1990 • 43 citations
[55] Expression of protein kinase c isotypes using baculovirus vectors
1991 • 43 citations
Protein kinase C activation and protooncogene expression in differentiation/retrodifferentiation of human U-937 leukemia cells.
1991 • 42 citations
Biochemical properties of rat protein kinase C‐η expressed in COS cells
1992 • 41 citations
Interleukin 3 stimulates phosphatidylcholine turnover in a mast/megakaryocyte cell line
1989 • 40 citations
Activation of purified human protein kinase C α and β I isoenzymes in vitro by Ca2+, phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate
1993 • 39 citations
Downregulation of protein kinase C‐γ is independent of a functional kinase domain
1991 • 37 citations
Down‐regulation of a kinase defective PKC‐α
1991 • 33 citations
Dual role for protein kinase C α as a regulator of ion secretion in the HT29cl.19A human colonic cell line
1992 • 33 citations
Inducible overexpression of human protein kinase C α in NIH 3T3 fibroblasts results in growth abnormalities
1992 • 31 citations
A pseudosubstrate peptide inhibits protein kinase C‐mediated phosphorylation in permeabilized Rat‐1 cells
1990 • 27 citations
Characterization of the 5'-flanking region of the rat protein kinase C gamma gene.
1990 • 26 citations
Down-regulation of protein kinase C in Swiss 3T3 fibroblasts is independent of its phosphorylating activity
1991 • 25 citations
Differential recovery of protein kinase C-α and -ɛ isozymes after long-term phorbol ester treatment in rat renal mesangial cells
1991 • 25 citations
The Leucine Zipper of c-Myc Is Required for Full Inhibition of Erythroleukemia Differentiation
1990 • 23 citations
Positive and negative regulation of the transcription of the human protein kinase C beta gene.
1992 • 23 citations
NPC 15437 interacts with the C1 domain of protein kinase C An analysis using mutant PKC constructs
1991 • 23 citations
Proteinkinase C β-isoform triggers the formation of prostanoids and superoxide in liver macrophages
1992 • 23 citations
c-myb effects on kinetic events during MEL cell differentiation.
1992 • 23 citations
Nucleotide sequence of the 3' portion of a human gene for protein kinase CβI/βII
1987 • 22 citations
A rise and fall in 1,2-diacylglycerol content signal hexamethylene bisacetamide-induced erythropoiesis.
1992 • 22 citations
Isolation of cloned mouse protein kinase C beta-II cDNA and its sequence
1990 • 22 citations
The hormonal control of gene transcription
1992 • 21 citations
Phenotypic effects of overexpression of PKCβ1 in rat liver epithelial cells
1989 • 21 citations
Retinoic Acid-Specific Induction of a Protein Kinase C Isoform during Differentiation of HL-60 Cells1
1992 • 20 citations
Activation of two discrete signaling pathways by erythropoietin.
1992 • 19 citations
Protein kinase C isozymes epsilon and alpha in murine erythroleukemia cells.
1992 • 19 citations
Identification of the phosphoserine residue in histone H1 phosphorylated by protein kinase C
1988 • 19 citations
Tumor promoter 12-O-tetradecanoylphorbol-13-acetate and sn-1,2-dioctanoylglycerol increase the phosphorylation of protein kinase C in cells.
1991 • 19 citations
Specificity of protein phosphatases in the dephosphorylation of protein kinase C
1986 • 17 citations
Expression of protein kinase C I in NIH 3T3 cells increases its growth response to specific activators
1990 • 16 citations
Modulation of the mitogenic activity of eukaryotic translation initiation factor-4E by protein kinase C.
1991 • 15 citations
Effects of protein kinase A and calcium/phospholipid-dependent kinase modulators in the process of HL-60 cell differentiation: their opposite effects between HL-60 cell and K-562 cell differentiation.
1991 • 12 citations
High‐efficiency expression of rat protein kinase C‐γ in baculovirus‐infected insect cells
1990 • 12 citations
Activation of protein kinase C by phosphatidylinositol 4,5-bisphosphate: Possible involvement in Na+H+ antiport down-regulation and cell proliferation
1991 • 11 citations
Identification of phosphatidylserine-binding proteins in human white blood cells
1990 • 10 citations
Protein kinase C gamma expression mimics phorbol ester-induced transcriptional activation of a murine VL30 enhancer element.
1991 • 9 citations
A (re)initiation‐dependent cell‐free protein‐synthesis system from mouse erythroleukemia cells
1986 • 9 citations
The Protein Kinase C-Related PKC-L(η) Gene Product Is Localized in the Cell Nucleus
1992 • 8 citations
Interleukin-3 induces translocation and down-regulation of protein kinase C in human platelets
1992 • 8 citations
Stimulation of proliferation of HL60 cells by low concentrations of 12-O-tetradecanoylphorbol-13-acetate and its relationship to the mitogenic effects of insulin
1992 • 5 citations
Expression of the kinase domain of mouse protein kinase C in E. coli.
1989 • 4 citations
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