Age-related alteration of PKC, a key enzyme in memory processes

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.

1979 • 1,970 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Protein kinase C

1991 • 914 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

1997 • 779 citations

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

1994 • 715 citations

Synaptic plasticity in the hippocampus: LTP and LTD

1994 • 653 citations

Preserved neuron number in the hippocampus of aged rats with spatial learning deficits.

1996 • 635 citations

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1995 • 559 citations

The Protein Kinase C Family for Neuronal Signaling

1994 • 545 citations

Modified hippocampal long-term potentiation in PKCγ-mutant mice

1993 • 507 citations

Identification of intracellular receptor proteins for activated protein kinase C.

1991 • 505 citations

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1992 • 455 citations

Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation.

1993 • 439 citations

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

1993 • 401 citations

Calcium and the aging nervous system

1987 • 384 citations

A Protein Kinase C Translocation Inhibitor as an Isozyme-selective Antagonist of Cardiac Function

1996 • 371 citations

Synaptic plasticity in the hippocampus

1979 • 357 citations

An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.

1985 • 334 citations

C2 Region-derived Peptides Inhibit Translocation and Function of β Protein Kinase C in Vivo

1995 • 322 citations

Amyloid β Protein Potentiates Ca²⁺ Influx Through L‐Type Voltage‐Sensitive Ca²⁺ Channels: A Possible Involvement of Free Radicals

1997 • 319 citations

Increased Susceptibility to Induction of Long-Term Depression and Long-Term Potentiation Reversal during Aging

1996 • 286 citations

An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.

1985 • 275 citations

Imaging of Memory-Specific Changes in the Distribution of Protein Kinase C in the Hippocampus

1989 • 271 citations

Inhibition of noradrenaline release by antibodies to B-50 (GAP-43)

1989 • 267 citations

Beta amyloid precursor protein mediates neuronal cell‐cell and cell‐surface adhesion

1991 • 244 citations

Mechanism of Interaction of Protein Kinase C with Phorbol Esters

1995 • 243 citations

Decreased levels of protein kinase C in Alzheimer brain

1988 • 242 citations

Hippocampal protein kinase C activity is reduced in poor spatial learners

1990 • 225 citations

More on target with protein phosphorylation: conferring specificity by location.

1996 • 225 citations

Age and neurochemical correlates of radial maze performance in rats

1981 • 217 citations

Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases.

1995 • 211 citations

Spatial and temporal changes in signal transduction pathways during LTP

1994 • 184 citations

Translocation Inhibitors Define Specificity of Protein Kinase C Isoenzymes in Pancreatic β-Cells

1997 • 173 citations

Differential involvement of protein kinase C isozymes in Alzheimer's disease

1990 • 168 citations

Phosphorylation of the presynaptic protein B-50 (GAP-43) is increased during electrically induced long-term potentiation

1992 • 160 citations

Bidirectional Regulation of Protein Kinase Mζ in the Maintenance of Long-Term Potentiation and Long-Term Depression

1996 • 157 citations

Role of the growth-associated protein B-50/GAP-43 in neuronal plasticity

1991 • 156 citations

Memory Storage and Neural Systems

1989 • 155 citations

Abusive stimulation of excitatory amino acid receptors: a strategy to limit neurotoxicity

1990 • 152 citations

Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes

1991 • 139 citations

CELLULAR AND MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE AND ANIMAL MODELS

1994 • 130 citations

Protein kinase C alteration is an early biochemical marker in Alzheimer's disease

1991 • 127 citations

Agonists and antagonists of protein kinase C function, derived from its binding proteins.

1994 • 125 citations

Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease.

1993 • 124 citations

Long-term potentiation as synaptic dialogue

1993 • 122 citations

Attenuated protein kinase C activity and translocation in Alzheimer's Disease brain

1994 • 118 citations

Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine

1987 • 118 citations

Changes in PKC gamma immunoreactivity in mouse hippocampus induced by spatial discrimination learning

1992 • 113 citations

Secretory processing of the Alzheimer amyloid βA4 protein precursor is increased by protein phosphorylation

1992 • 109 citations

An age-related spatial learning deficit: Choline uptake distinguishes “impaired” and “unimpaired” rats

1988 • 108 citations

Interaction of protein kinase C with RACKI, a receptor for activated C-kinase: a role in β protein kinase C mediated signal transduction

1995 • 107 citations

Temporal Differences in the Phosphorylation State of Pre- and Postsynaptic Protein Kinase C Substrates B-50/GAP-43 and Neurogranin during Long Term Potentiation

1995 • 106 citations

Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients

1993 • 105 citations

Pharmacological evidence for a role of long‐term potentiation in memory

1994 • 101 citations

Reduced Protein Kinase C Immunoreactivity and Altered Protein Phosphorylation in Alzheimer's Disease Fibroblasts

1989 • 100 citations

More on target with protein phosphorylation: conferring specificity by location

1996 • 93 citations

Effect of Age on Brain Cortical Protein Kinase C and Its Mediation of 5‐Hydroxytryptamine Release

1989 • 93 citations

Ca²⁺‐Dependent and Ca²⁺‐Independent Protein Kinase C Changes in the Brains of Patients with Alzheimer's Disease

1996 • 91 citations

The role of anchoring protein rack1 in pkc activation in the ageing rat brain

1997 • 88 citations

Functional Impairment in Protein Kinase C by RACK1 (Receptor for Activated C Kinase 1) Deficiency in Aged Rat Brain Cortex

1996 • 86 citations

Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons

1991 • 85 citations

Cognitive kinases.

1993 • 82 citations

Protein kinase C activity, translocation, and conventional isoforms in aging rat brain

1995 • 75 citations

Demonstration of presynaptic protein kinase C activation following long-term potentiation in rat hippocampal slices

1993 • 70 citations

For the Cortex, Neuron Loss May Be Less Than Thought

1996 • 65 citations

beta-Amyloid Formation as a Potential Therapeutic Target for Alzheimer's Disease

1994 • 64 citations

Defective phorbol ester-stimulated secretion of β-amyloid precursor protein from Alzheimer's disease fibroblasts

1995 • 63 citations

Acute phorbol ester treatment improves spatial learning performance in rats

1991 • 56 citations

Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme

1992 • 55 citations

Action of amyloid beta-protein on protein kinase C activity

1991 • 54 citations

Assessment of protein kinase C isozymes by two‐site enzyme immunoassay in human brains and changes in Alzheimer's disease

1993 • 50 citations

Regulation of phorbol ester binding and protein kinase C activity in aged rat brain

1990 • 50 citations

Changes in Protein Kinases in Brain Aging and Alzheimer??s Disease

1995 • 50 citations

Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine

1991 • 50 citations

Protein and Molecular Characterization of Hippocampal Protein Kinase C in C57BL/6 and DBA/2 Mice

1995 • 50 citations

Protein kinase C activity in the hippocampus following spatial learning tasks in mice

1994 • 49 citations

The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice

1992 • 41 citations

Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: in vitro and in vivo studies

1994 • 34 citations

Cognition stimulating drugs modulate protein kinase C activity in cerebral cortex and hippocampus of adult rats

1993 • 33 citations

β A4 amyloid protein and its precursor in Alzheimer's disease

1992 • 31 citations

Defective Protein Kinase C α Leads to Impaired Secretion of Soluble β‐Amyloid Precursor Protein from Alzheimer's Disease Fibroblasts^a

1996 • 31 citations

The regulatory domain of protein kinase C beta 1 contains phosphatidylserine- and phorbol ester-dependent calcium binding activity.

1993 • 29 citations

Fibroblasts of patients affected by Down's syndrome oversecrete amyloid precursor protein and are hyporesponsive to protein kinase C stimulation

1996 • 28 citations

Characterization and Distribution of Protein Kinase C Isoforms in Human Skin Fibroblasts

1994 • 27 citations

Chapter 15 Neuronal cell membranes and brain aging

1986 • 27 citations

Decreased phospholipase C-β immunoreactivity, phosphoinositide metabolism, and protein kinase C activation in senescent F-344 rat brain

1995 • 27 citations

Alzheimer and beta-amyloid-treated fibroblasts demonstrate a decrease in a memory-associated GTP-binding protein, Cp20.

1995 • 26 citations

Specific binding of the alzheimer βA4 amyloid precursor to collagen, laminin, and heparin

1992 • 26 citations

Chapter 13: Protein kinase C substrate B-50 (GAP-43) and neurotransmitter release

1991 • 26 citations

Phosphorylation of the Conditioning‐Associated GTP‐Binding Protein cp20 by Protein Kinase C

1995 • 25 citations

Muscling transplants into mice.

1996 • 23 citations

Cellular and synaptic alterations in the aging brain

1990 • 23 citations

Age-Related Changes in Signal Transduction

1994 • 22 citations

Effects of peroxidation and aging on rat neocortical ACh-release and protein kinase C

1994 • 20 citations

Modulation of B-50 Phosphorylation and Polyphosphoinositide Metabolism in Synaptic Plasma Membranes by Protein Kinase C, Phorbol Diesters and Acth

1988 • 19 citations

Activated protein kinase C binds to intracellular receptors in rat hepatocytes

1993 • 19 citations

Differences in β-amyloid (β/A4) deposition in human patients with Down's syndrome and sporadic Alzheimer's disease

1994 • 18 citations

Muscling Transplants Into Mice

1996 • 17 citations

Expression and Regulation of Calcium Independent Protein Kinase C in NG 108-15 Cell Differentiation

1994 • 15 citations

Differential isoform-specific regulation of calcium-independent protein kinase C in rat cerebral cortex

1996 • 14 citations

AGE-RELATED-CHANGES IN BRAIN PROTEIN-KINASE-C EXPRESSION, ACTIVITY, AND TRANSLOCATION

1993 • 8 citations