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Mitochondrially Associated Hepatitis B Virus X Protein Constitutively Activates Transcription Factors STAT-3 and NF-κB via Oxidative Stress

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Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?

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Erythropoietin: a Model System for Studying Oxygen-Dependent Gene Regulation

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[14] Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-κB

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Immunological functions of the pulmonary epithelium

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Rethinking cystic fibrosis pathology: the critical role of abnormal reduced glutathione (GSH) transport caused by CFTR mutation

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Cellular Enrichment with Polyunsaturated Fatty Acids Induces an Oxidative Stress and Activates the Transcription Factors AP1 and NFκB

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Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-κB in vitro

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Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB.

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Glucosamine modulates IL‐1‐induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF‐κB pathway

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Cobalt Induces Heme Oxygenase-1 Expression by a Hypoxia-inducible Factor-independent Mechanism in Chinese Hamster Ovary Cells

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Supplementation of N‐acetylcysteine inhibits NFκB activation and protects against alloxan‐induced diabetes in CD‐1 mice

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Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB 1 1Abbreviations: A549 cells, human alveolar epithelial type II cell line; AP-1, activator protein-1; BSO; dl-buthionine (SR)-sulfoximine; COPD, chronic obstructive pulmonary disease; DMEM, Dulbecco’s modified Eagle’s medium; DTT, dithiothreitol; GSHMEE, glutathione monoethyl ester; H2O2, hydrogen peroxide; IkB, inhibitory binding protein kB; LDH, lactic dehydrogenase; NAC, N-acetyl-…

2001 • 129 citations

Thiols decrease human interleukin (IL) 4 production and IL-4-induced immunoglobulin synthesis.

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Oxidative Stress Increases A₁Adenosine Receptor Expression by Activating Nuclear Factor κB

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PM₁₀-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-α

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2001 • 117 citations

Dietary Zinc Supplementation Inhibits NFκB Activation and Protects Against Chemically Induced Diabetes in CD1 Mice

2001 • 114 citations

SOD1 Down-Regulates NF-κB and c-Myc Expression in Mice after Transient Focal Cerebral Ischemia

2001 • 114 citations

Thiol regulation of the production of TNF-α, IL-6 and IL-8 by human alveolar macrophages

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Gene Regulation by Reactive Oxygen Species

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2-Acetylaminofluorene Up-regulates Rat mdr1bExpression through Generating Reactive Oxygen Species That Activate NF-κB Pathway

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Treatment With Glutathione Precursor Decreases Cytokine Activity

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O₂-evoked regulation of HIF-1α and NF-κB in perinatal lung epithelium requires glutathione biosynthesis

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Oxidative stress induces proorphanin FQ and proenkephalin gene expression in astrocytes through p38‐ and ERK‐MAP kinases and NF‐κB

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Antioxidant Treatment Attenuates Cytokine and Chemokine Levels in Murine Macrophages Following Silica Exposure

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Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. I. Differential Regulation of Lipopolysaccharide-Mediated Proinflammatory Cytokine (Interleukin-6 and Tumor Necrosis Factor-α) Biosynthesis in Alveolar Epithelial Cells

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Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors.

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Differential induction of nuclear NF-kappa B by protein phosphatase inhibitors in primary and transformed human cells. Requirement for both oxidation and phosphorylation in nuclear translocation.

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Selenium: A key element that controls NF‐κB activation and IκBα half life

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Mitochondria Mediate Tumor Necrosis Factor-α/NF-κB Signaling in Skeletal Muscle Myotubes

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Activation of Nuclear Factor- κ B Transcriptional Activity in Airway Epithelial Cells by Thioredoxin but Not by N-Acetyl-Cysteine and Glutathione

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A protective role for HIF-1 in response to redox manipulation and glucose deprivation: implications for tumorigenesis

2002 • 83 citations

Thiol regulation of pro-inflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium.

2001 • 83 citations

Cadmium blocks hypoxia‐inducible factor (HIF)‐1‐mediated response to hypoxia by stimulating the proteasome‐dependent degradation of HIF‐1α

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The involvement of l-γ-glutamyl-l-cysteinyl-glycine (glutathione/GSH) in the mechanism of redox signaling mediating MAPKp38-dependent regulation of pro-inflammatory cytokine production

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Impaired Pulmonary NF-κB Activation in Response to Lipopolysaccharide in NADPH Oxidase-Deficient Mice

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Effects of bucillamine and N-acetyl-<scp>l</scp>-cysteine on cytokine production and collagen-induced arthritis (CIA)

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Redox Regulation of Lipopolysaccharide(LPS)-Induced Interleukin-8 (IL-8) Gene Expression Mediated by NFκB and AP-1 in Human Astrocytoma U373 Cells

1997 • 78 citations

CHEMIOXYEXCITATION (Δp O2/ROS)-DEPENDENT RELEASE OF IL-1β, IL-6 AND TNF-α: EVIDENCE OF CYTOKINES AS OXYGEN-SENSITIVE MEDIATORS IN THE ALVEOLAR EPITHELIUM

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Regulation of NF-κB and Disease Control: Identification of a Novel Serine Kinase and Thioredoxin as Effectors for Signal Transduction Pathway for NF-κB Activation

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Glutathione Depletion is Associated with Augmenting a Proinflammatory Signal: Evidence for an Antioxidant/Pro-oxidant Mechanism Regulating Cytokines in the Alveolar Epithelium

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Hypoxia-inducible Factor 1α (HIF-1α) Is a Non-heme Iron Protein

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α-Melanocyte-related tripeptide, Lys-d-Pro-Val, ameliorates endotoxin-induced nuclear factor κB translocation and activation: evidence for involvement of an interleukin-1β193‒195 receptor antagonism in the alveolar epithelium

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Apoptosis in Ca² + reperfusion injury of cultured astrocytes: roles of reactive oxygen species and NF‐κB activation

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Hypoxia Regulation of Gene Transcription

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An immediate endothelial cell signaling response to lung ischemia

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Glutathione Downregulates the Phosphorylation of IκB: Autoloop Regulation of the NF-κB-Mediated Expression of NF-κB Subunits by TNF-α in Mouse Vascular Endothelial Cells

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Regulation of the DNA binding activity of NF-κB

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Thiol regulation of endotoxin-induced release of tumour necrosis factor α from isolated rat Kupffer cells

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Recombinant human interleukin (IL)-1 beta-mediated regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism.

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Inflammation and the Regulation of Glutathione Level in Lung Epithelial Cells

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Alpha-Phenyl-tert-butylnitrone (PBN) inhibits NFκB activation offering protection against chemically induced diabetes

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Antioxidants Differentially Regulate Activation of Nuclear Factor-κB, Activator Protein-1, c-Jun Amino-Terminal Kinases, and Apoptosis Induced by Tumor Necrosis Factor: Evidence that JNK and NF-κB Activation Are Not Linked to Apoptosis

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Reactive oxygen intermediates stimulate interleukin-6 production in human bronchial epithelial cells

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Localization of γ-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease

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The Differential Expression of Apoptosis Factors in the Alveolar Epithelium Is Redox Sensitive and Requires NF-κB (RelA)-Selective Targeting

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MODULATION OF IL-1-INDUCED CHEMOKINE EXPRESSION IN HUMAN MESANGIAL CELLS THROUGH ALTERATIONS IN REDOX STATUS

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Amiloride Blockades Lipopolysaccharide-Induced Proinflammatory Cytokine Biosynthesis in an I κ B- α /NF- κ B–Dependent Mechanism

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Cytokines. 1. Overview.

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Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. II. Evidence for the Involvement of an Inhibitory-κB/Nuclear Factor-κB-Sensitive Pathway in Alveolar Epithelial Cells

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2002 • 50 citations

Hyperoxia upregulates the NO pathway in alveolar macrophages in vitro: role of AP-1 and NF-κB

2001 • 50 citations

Tumor Necrosis Factor and Reactive Oxygen Species Cooperative Cytotoxicity Is Mediated via Inhibition of NF-κB

2000 • 50 citations

Thioredoxin Inhibits Tumor Necrosis Factor- or Interleukin-1-Induced NF-κB Activation at a Level Upstream of NF-κB-Inducing Kinase

2000 • 50 citations

Nickel requires hypoxia-inducible factor-1α, not redox signaling, to induce plasminogen activator inhibitor-1

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Transmembrane Redox Signaling Activates NF-κB in Macrophages

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Gamma-Glutamyltranspeptidase-Dependent Glutathione Catabolism Results in Activation of NF-kB

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Direct Comparison of the Nature of Mouse and Human GST T1-1 and the Implications on Dichloromethane Carcinogenicity

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Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis

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Redox regulation of NF-kappa B DNA binding activity by dihydrolipoate.

1995 • 48 citations

Activation of transcription factors by drugs inducing oxidative stress in rat liver

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NF-kappa B Transcription Factor and Human Immunodeficiency Virus Type 1 (HIV-1) Activation by Methylene Blue Photosensitization

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Nuclear factor κB activity in response to oxidants and antioxidants

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Redox Signaling-Mediated Regulation of Lipopolysaccharide-Induced Proinflammatory Cytokine Biosynthesis in Alveolar Epithelial Cells

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Regulation of lipopolysaccharide-mediated interleukin-1β release by N-acetylcysteine in THP-1 cells

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Induction of TNFalpha in macrophages by vanadate is dependent on activation of transcription factor NF-kappaB and free radical reactions.

1999 • 47 citations

Influence of the cellular redox state on NF-?B-regulated gene expression

2000 • 46 citations

The Activity of NF-kappaB in Swiss 3T3 Cells Exposed to Aqueous Extracts of Cigarette Smoke Is Dependent on Thioredoxin

2001 • 46 citations

[17] Redox regulation of activation of NF-κB transcription factor complex: Effects of N-acetylcysteine

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One-Electron Reduction of Chromium(VI) by α-Lipoic Acid and Related Hydroxyl Radical Generation, dG Hydroxylation and Nuclear Transcription Factor-κB Activation

1997 • 42 citations

Redox regulation of TNF-α biosynthesis: Augmentation by irreversible inhibition of γ-glutamylcysteine synthetase and the involvement of an IκB-α/NF-κB-independent pathway in alveolar epithelial cells

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Cooperation of protein disulfide isomerase and redox environment in the regulation of NF‐κB and AP1 binding to DNA

1996 • 40 citations

Hypoxia and oxidative stress in breast cancer Hypoxia signalling pathways

2001 • 36 citations

L-Buthionine-(S,R)-sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, augments LPS-mediated pro-inflammatory cytokine biosynthesis: evidence for the implication of an IkappaB-alpha/NF-kappaB insensitive pathway.

2002 • 36 citations

TNF‐α dependent NF‐κB activation in cultured canine keratinocytes is partly mediated by reactive oxygen species

2001 • 34 citations

Role for Copper in Transient Oxidation and Nuclear Translocation of MTF-1, but Not of NF-κB, by the Heme–Hemopexin Transport System

2000 • 33 citations

Nuclear Factor-κB-Independent Regulation of Lipopolysaccharide-Mediated Interleukin-6 Biosynthesis

2002 • 31 citations

Involvement of Different Transduction Pathways in NF-kB Activation by Several Inducers

1997 • 28 citations

The biphasic immunoregulation of pyrimidylpiperazine (Y‐40138) is IL‐10 sensitive and requires NF‐κB targeting in the alveolar epithelium

2001 • 27 citations

Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa B During Hepatic Ischemia in Rats

2000 • 26 citations

Glutathione depletion inhibits oxidant-induced activation of nuclear factor-kappa B, AP-1, and c-Jun/ATF-2 in cultured guinea-pig gastric epithelial cells

1998 • 26 citations

Thiol modulation inhibits the interleukin (IL)‐1‐mediated activation of an IL‐1 receptor‐associated protein kinase and NF‐xB

1997 • 26 citations

Immunomodulatory Potential of Thymulin–Zn2+ in the Alveolar Epithelium: Amelioration of Endotoxin-Induced Cytokine Release and Partial Amplification of a Cytoprotective IL-10-Sensitive Pathway

2000 • 26 citations

RECOMBINANT TNF-α MEDIATED REGULATION OF THE IκB-α/NF-κB SIGNALING PATHWAY: EVIDENCE FOR THE ENHANCEMENT OF PRO- AND ANTI-INFLAMMATORY CYTOKINES IN ALVEOLAR EPITHELIAL CELLS

2002 • 26 citations

Antioxidant Treatment Inhibits Activation of Myocardial Nuclear Factor κB and Inhibits Nitrosylation of Myocardial Heme Protein in Cardiac Transplant Rejection

2001 • 25 citations

Nuclear Factor-κB Blockade Attenuates but Does Not Abrogate Lipopolysaccharide-Dependent Tumor Necrosis Factor-α Biosynthesis in Alveolar Epithelial Cells

2001 • 24 citations

Evidence for non‐oxidative dopamine cytotoxicity: potent activation of NF‐κ B and lack of protection by anti‐oxidants

2001 • 24 citations

Nuclear factor (NF)-κB blockade attenuates but does not abrogate LPS-mediated interleukin (IL)-1β biosynthesis in alveolar epithelial cells

2002 • 24 citations

NF-κB Blockade Reduces the O 2 -Evoked Rise in Na + Conductance in Fetal Alveolar Cells

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Cellular redox status influences both cytotoxic and NF‐κB activation in natural killer cells

1997 • 23 citations

Impairment of the Mitochondrial Electron Chain Transport Prevents NF-κB Activation by Hydrogen Peroxide

1998 • 23 citations

DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance

2001 • 22 citations

Oxidative Stress and NF-κB Activation: Correlation in Patients Following Allogeneic Bone Marrow Transplantation

2000 • 20 citations

The ex Vivo Differential Expression of Apoptosis Signaling Cofactors in the Developing Perinatal Lung: Essential Role of Oxygenation During the Transition from Placental to Pulmonary-Based Respiration

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Potentiation of the cell specific toxicity of paraquat by 1,3-BIS(2-chloroethyl)-1-nitrosourea (BCNU)

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Lung redox homeostasis: emerging concepts

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Glutathione and p53 independently mediate responses against oxidative stress in ES cells

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Involvement of reactive oxygen species in TNF-α mediated activation of the transcription factor NF-κB in canine dermal fibroblasts

1999 • 15 citations

Free Radical Activity of Industrial Fibers: Role of Iron in Oxidative Stress and Activation of Transcription Factors

1997 • 14 citations

An endogenous redox molecule, thioredoxin, regulates transactivation of epidermal growth factor receptor and activation of NF‐κB by lysophosphatidic acid

2001 • 14 citations

Pyrrolidine dithiocarbamate inhibits serum-induced NF-κB activation and induces apoptosis in ROS 17/2.8 osteoblasts

2001 • 11 citations

Inhibition of NFkappaB activity by oxidative processes in intact cells — mechanism of action of pyrolidine dithiocarbamate and diamide

1996 • 10 citations

Interactions of lanthanum with purified and intact cell acetylcholinesterase of electrophorus electricus

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Evidence for a redox-sensitive protein tyrosine kinase in nuclear factor kappa B activation and interleukin 2 production in EL4.NOB1 cells

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[18] Redox regulation of DNA-Protein Interactions by biothiols

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