Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

1994 • 1,512 citations

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

1999 • 1,494 citations

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

1991 • 1,432 citations

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

2000 • 1,411 citations

Chemoprevention of Cancer

2008 • 1,269 citations

Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

1999 • 1,233 citations

INDUCTION OF CYTOCHROME P4501A1

1999 • 1,124 citations

Regulation of JNK signaling by GSTp

1999 • 1,102 citations

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

2001 • 1,085 citations

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase ₁ gene

1996 • 1,027 citations

An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen

2001 • 745 citations

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

2001 • 721 citations

Functional antioxidant responsive elements

1997 • 702 citations

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

1993 • 655 citations

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

2001 • 639 citations

Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site

1996 • 622 citations

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

1995 • 603 citations

Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2

1999 • 584 citations

Nrf2 is essential for protection against acute pulmonary injury in mice

1999 • 572 citations

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

2001 • 568 citations

Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

1998 • 553 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

1990 • 522 citations

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

2000 • 515 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene

1991 • 499 citations

Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.

2001 • 461 citations

Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein

2001 • 454 citations

Constitutive and β-Naphthoflavone-induced Expression of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene Is Regulated by a Distal Antioxidant Response Element/TRE Sequence

1997 • 442 citations

Chemical and molecular regulation of enzymes that detoxify carcinogens.

1993 • 426 citations

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.

1988 • 408 citations

Mechanism of Heme Oxygenase-1 Gene Activation by Cadmium in MCF-7 Mammary Epithelial Cells

2000 • 406 citations

Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1

2001 • 397 citations

Transcriptional Regulation of the Antioxidant Response Element

2000 • 364 citations

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.

1993 • 344 citations

Regulatory mechanisms of cellular response to oxidative stress

1999 • 340 citations

Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism

2000 • 339 citations

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.

2001 • 327 citations

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

2000 • 317 citations

Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein

2000 • 309 citations

Glutathione S-transferases and drug resistance

1991 • 299 citations

Molecular Cloning and Functional Characterization of a New Cap'n' Collar Family Transcription Factor Nrf3

1999 • 290 citations

The world according to Maf

1997 • 285 citations

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

1998 • 278 citations

Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals

1999 • 278 citations

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.

1985 • 262 citations

An Electrophile Responsive Element (EpRE) Regulates β-Naphthoflavone Induction of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene

1998 • 260 citations

The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.

1993 • 260 citations

Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.

1992 • 230 citations

Phosphatidylinositol 3-Kinase, Not Extracellular Signal-regulated Kinase, Regulates Activation of the Antioxidant-Responsive Element in IMR-32 Human Neuroblastoma Cells

2001 • 229 citations

Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression.

1995 • 222 citations

Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin

1991 • 213 citations

Small Maf (MafG and MafK) Proteins Negatively Regulate Antioxidant Response Element-mediated Expression and Antioxidant Induction of the NAD(P)H:Quinone Oxidoreductase1 Gene

2000 • 205 citations

The Heme-Responsive Element of the Mouse Heme Oxygenase-1 Gene Is an Extended AP-1 Binding Site That Resembles the Recognition Sequences for MAF and NF-E2 Transcription Factors

1996 • 197 citations

p38 Mitogen-activated Protein Kinase Negatively Regulates the Induction of Phase II Drug-metabolizing Enzymes That Detoxify Carcinogens

2000 • 193 citations

Activation of the Hematopoietic Progenitor Kinase-1 (HPK1)-dependent, Stress-activated c-Jun N-terminal Kinase (JNK) Pathway by Transforming Growth Factor β (TGF-β)-activated Kinase (TAK1), a Kinase Mediator of TGF β Signal Transduction

1997 • 193 citations

The CNC Basic Leucine Zipper Factor, Nrf1, Is Essential for Cell Survival in Response to Oxidative Stress-inducing Agents

1999 • 176 citations

Inactivation of Protein-tyrosine Phosphatases as Mechanism of UV-induced Signal Transduction

1999 • 166 citations

Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver.

2000 • 145 citations

Cobalt Induces Heme Oxygenase-1 Expression by a Hypoxia-inducible Factor-independent Mechanism in Chinese Hamster Ovary Cells

2001 • 141 citations

酵母での遺伝的選択によるNF-E2関連転写因子、Nrf1のクローニング

1993 • 123 citations

Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: Binding-site selection and regulation of transcription

1998 • 115 citations

Activation of Phosphatidylinositol 3-Kinase and Akt bytert-Butylhydroquinone Is Responsible for Antioxidant Response Element-Mediated rGSTA2 Induction in H4IIE Cells

2001 • 114 citations

The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development.

1997 • 113 citations

The Essential Role of Phosphatidylinositol 3-Kinase and of p38 Mitogen-Activated Protein Kinase Activation in the Antioxidant Response Element-Mediated rGSTA2 Induction by Decreased Glutathione in H4IIE Hepatoma Cells

2000 • 112 citations

Antioxidant-Inducible Genes

1996 • 111 citations

11. Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress

1999 • 103 citations

Suppression of Rat Thromboxane Synthase Gene Transcription by Peroxisome Proliferator-activated Receptor γ in Macrophages via an Interaction with NRF2

2000 • 99 citations

Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF promoter in stimulated mast cells

1998 • 86 citations

The Identification of a Cis-element and a Trans-acting Factor Involved in the Response to Polyamines and Polyamine Analogues in the Regulation of the Human Spermidine/Spermine N 1-Acetyltransferase Gene Transcription

1998 • 86 citations

Mechanism of Metallothionein Gene Regulation by Heme-Hemopexin

1995 • 66 citations

TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the γ-glutamylcysteine synthetase (GCS) heavy subunit promoter

2001 • 65 citations

Identification of dithiolethione-inducible gene-1 as a leukotriene B4 12-hydroxydehydrogenase: implications for chemoprevention

1998 • 65 citations

Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene

2001 • 63 citations

Oxidative stress induces the levels of a MAFG homolog in hamster HA-1 cells

1996 • 56 citations

Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development

2000 • 51 citations

Superoxide enhances interleukin 1β–mediated transcription of the hepatocyte-inducible nitric oxide synthase gene

2000 • 50 citations

Reduced oxidative-stress response in red blood cells from p45NFE2-deficient mice

2001 • 49 citations

The redox-sensitive human antioxidant responsive element induces gene expression under low oxygen conditions

1998 • 31 citations

Induction of murine intestinal and hepatic peroxiredoxin MSP23 by dietary butylated hydroxyanisole

2000 • 27 citations

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