Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. I. Differential Regulation of Lipopolysaccharide-Mediated Proinflammatory Cytokine (Interleukin-6 and Tumor Necrosis Factor-α) Biosynthesis in Alveolar Epithelial Cells

Pentoxifylline

1987 • 1,768 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?

2001 • 1,237 citations

Guanylyl cyclases and signaling by cyclic GMP.

2000 • 1,192 citations

Modulation of Inflammation and Immunity by Cyclic AMP

1974 • 923 citations

Mitogen-activated protein kinase cascades and regulation of gene expression

1996 • 759 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Cyclic GMP Phosphodiesterase-5: Target of Sildenafil

1999 • 536 citations

Glutathione Deficiency in the Epithelial Lining Fluid of the Lower Respiratory Tract in Idiopathic Pulmonary Fibrosis

1989 • 472 citations

Cytokines of the Lung

1990 • 443 citations

Tailoring cAMP-signalling responses through isoform multiplicity

1997 • 437 citations

Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3)

1997 • 418 citations

Inosine Inhibits Inflammatory Cytokine Production by a Posttranscriptional Mechanism and Protects Against Endotoxin-Induced Shock

2000 • 316 citations

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of Drosophila melanogaster are Potential Targets for Antidepressant Drugs

1993 • 287 citations

Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1α and NF-κB Redox Sensitivity

2000 • 237 citations

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

1993 • 233 citations

The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells

1993 • 222 citations

Oxidized Glutathione Is Increased in the Alveolar Fluid of Patients with the Adult Respiratory Distress Syndrome

1993 • 206 citations

Differential Regulation of Interleukin-10 (IL-10) and IL-12 by Glucocorticoids In Vitro

1998 • 203 citations

Immunological functions of the pulmonary epithelium

1995 • 167 citations

Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants

1999 • 167 citations

Suppression of human inflammatory cell function by subtype‐selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B

1999 • 141 citations

Pharmacological modulation of secondary mediator systems–cyclic AMP and cyclic GMP–on inflammatory hyperalgesia

1999 • 139 citations

SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions.

1998 • 135 citations

Bronchopulmonary dysplasia and oxidative stress: are we closer to an understanding of the pathogenesis of BPD?

1997 • 134 citations

Cyclic nucleotide phosphodiesterase (PDE) inhibitors and immunomodulation

1999 • 125 citations

Phosphodiesterase 4 inhibitors, structurally unrelated to Rolipram, as promising agents for the treatment of asthma and other pathologies

2000 • 108 citations

Interleukin-8 Mediates Injury from Smoke Inhalation to both the Lung Endothelial and the Alveolar Epithelial Barriers in Rabbits

1999 • 101 citations

O₂-evoked regulation of HIF-1α and NF-κB in perinatal lung epithelium requires glutathione biosynthesis

2000 • 101 citations

Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis

1996 • 96 citations

Salbutamol Up-regulates PDE4 Activity and Induces a Heterologous Desensitization of U937 Cells to Prostaglandin E2

1995 • 92 citations

A Pharmacokinetic and Pharmacodynamic Evaluation of Milrinone in Adults Undergoing Cardiac Surgery

1995 • 87 citations

SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor alpha and interleukin-4 production in vivo.

1998 • 87 citations

CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells.

1995 • 86 citations

Pentoxifylline ameliorates cerulein-induced pancreatitis in rats: role of glutathione and nitric oxide.

2000 • 86 citations

Thiol regulation of pro-inflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium.

2001 • 83 citations

VX-745. Vertex Pharmaceuticals.

2001 • 79 citations

Diminished Response of Werner's Syndrome Fibroblasts to Growth Factors PDGF and FGF

1986 • 79 citations

ALVEOLAR EPITHELIAL BARRIER

2000 • 79 citations

CHEMIOXYEXCITATION (Δp O2/ROS)-DEPENDENT RELEASE OF IL-1β, IL-6 AND TNF-α: EVIDENCE OF CYTOKINES AS OXYGEN-SENSITIVE MEDIATORS IN THE ALVEOLAR EPITHELIUM

2001 • 76 citations

Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV.

1996 • 75 citations

α-Melanocyte-related tripeptide, Lys-d-Pro-Val, ameliorates endotoxin-induced nuclear factor κB translocation and activation: evidence for involvement of an interleukin-1β193‒195 receptor antagonism in the alveolar epithelium

2001 • 70 citations

Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig.

1998 • 69 citations

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B₄ in a novel human whole blood assay

1999 • 68 citations

[46] Methylxanthine inhibitors of phosphodiesterases

1988 • 66 citations

Activation of wild-type and ΔF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms

1999 • 66 citations

Effect of lisofylline and pentoxifylline on the bacterial‐stimulated production of TNF‐α, IL‐1β and IL‐10 by human leucocytes

1997 • 63 citations

Suppression of IL-12 production by phosphodiesterase inhibition in murine endotoxemia is IL-10 independent

1998 • 62 citations

Chemotherapeutic potential of phosphodiesterase inhibitors

1998 • 58 citations

The Differential Expression of Apoptosis Factors in the Alveolar Epithelium Is Redox Sensitive and Requires NF-κB (RelA)-Selective Targeting

2000 • 58 citations

Differential effects of pentoxifylline, a non-specific phosphodiesterase inhibitor, on the production of IL-10, IL-12 p40 and p35 subunits by murine peritoneal macrophages

2000 • 57 citations

Allergic bronchopulmonary aspergillosis: New concepts of pathogenesis and treatment

2001 • 57 citations

Resistance of the Alveolar Epithelium to Injury from Septic Shock in Sheep

1995 • 56 citations

The In Vivo Effects of Milrinone on the Airways of Cystic Fibrosis Mice and Human Subjects

1999 • 53 citations

Cytokines. 1. Overview.

1993 • 52 citations

Differential expression of cyclic nucleotide phosphodiesterase 3 and 4 activities in human T cell clones specific for myelin basic protein.

1997 • 52 citations

Genes, Receptors, Signals and Responses to Lipopolysaccharide Endotoxin

2000 • 51 citations

Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis

1998 • 48 citations

Influence of pentoxifylline on cytokine levels and inflammatory parameters in septic shock

1996 • 46 citations

Pentoxifylline inhibits interleukin-2-induced toxicity in C57BL/6 mice but preserves antitumor efficacy.

1992 • 42 citations

Anti-inflammatory activities of a new series of selective phosphodiesterase 4 inhibitors derived from 9-benzyladenine.

2000 • 40 citations

The differential effect of pentoxifylline on cytokine production by alveolar macrophages and its clinical implications

1999 • 39 citations

The cGMP-specific Phosphodiesterase Inhibitor E4021 Dilates the Pulmonary Circulation

1999 • 37 citations

Regulation of IL-15-stimulated TNF-alpha production by rolipram.

1999 • 33 citations

The biphasic immunoregulation of pyrimidylpiperazine (Y‐40138) is IL‐10 sensitive and requires NF‐κB targeting in the alveolar epithelium

2001 • 27 citations

Pathogenesis of respiratory infections and host defenses

1996 • 27 citations

Regulation of IL-15-Stimulated TNF-α Production by Rolipram

1999 • 26 citations

Cardiovascular cyclic nucleotide phosphodiesterases and their role in regulating cardiovascular function

1992 • 25 citations

Oxidant injury to the alveolar epithelium: biochemical and pharmacologic studies.

1993 • 25 citations

Effect of DMPPO, a phosphodiesterase type 5 inhibitor, on hypoxic pulmonary hypertension in rats

1998 • 24 citations

A novel anti-rheumatic drug suppresses tumor necrosis factor-α and augments interleukin-10 in adjuvant arthritic rats

2000 • 23 citations

A novel dual regulator of tumor necrosis factor-α and interleukin-10 protects mice from endotoxin-induced shock

2000 • 20 citations

New ideas on the pathophysiology and treatment of lung disease

1998 • 18 citations

Amrinone reduces ischaemia–reperfusion injury in rat heart

2000 • 17 citations

Effects of the phosphodiesterase 4 inhibitor RPR 73401 in a model of immunological inflammation

2000 • 16 citations

Serum Concentrations of Pentoxifylline and its Metabolites in Premature Infants with Sepsis when Administered by Continuous Intravenous Infusion

1997 • 14 citations

Effect of Pentoxifylline on Nitric Oxide Released by Murine Macrophages

1995 • 9 citations

Overview: Cardiovascular & Renal; Cyclic nucleotide phosphodiesterase inhibitors

1995 • 9 citations

Targeting the alveolar epithelium in acute lung injury

1996 • 7 citations

Mechanisms of airway inflammation in cystic fibrosis

1996 • 6 citations

Resistance of the alveolar epithelium to injury from septic shock in sheep.

1995 • 6 citations