Increased Transcription of the Regulatory Subunit of γ-Glutamylcysteine Synthetase in Rat Lung Epithelial L2 Cells Exposed to Oxidative Stress or Glutathione Depletion

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

GLUTATHIONE

1983 • 5,487 citations

A fluorometric method for determination of oxidized and reduced glutathione in tissues

1976 • 4,013 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Current Protocols in Molecular Biology

1989 • 1,916 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides

1980 • 1,179 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

Quinone chemistry and toxicity

1992 • 732 citations

Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.

1975 • 729 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

Redox and addition chemistry of quinoid compounds and its biological implications

1989 • 388 citations

Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.

1993 • 368 citations

Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells

1994 • 303 citations

Redox cycling and sulphydryl arylation; Their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes

1988 • 296 citations

Superoxide Radical and Hydrogen Peroxide in Mitochondria

1982 • 273 citations

Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements

1994 • 265 citations

Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase.

1993 • 235 citations

Identification of a Putative Antioxidant Response Element in the 5′-Flanking Region of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene

1995 • 187 citations

Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines.

1995 • 176 citations

Exogenous glutathione protects intestinal epithelial cells from oxidative injury.

1986 • 173 citations

Renal glutathione transport. Characteristics of the sodium-dependent system in the basal-lateral membrane.

1984 • 171 citations

Amino acid sequence of rat kidney gamma-glutamylcysteine synthetase.

1990 • 171 citations

[14] Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-κB

1994 • 168 citations

gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells.

1994 • 163 citations

Induction of γ‐glutamylcysteine synthetase by cigarette smoke is associated with AP‐1 in human alveolar epithelial cells

1996 • 155 citations

Glutathione uptake and protection against oxidative injury in isolated kidney cells

1988 • 152 citations

Clonal isolation of differentiated rat lung cells

1974 • 142 citations

On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation.

1988 • 123 citations

Cloning and Sequencing of the cDNA for the Light Subunit of Human Liver γ-Glutamylcysteine Synthetase and Relative RNA Levels for Heavy and Light Subunits in Human Normal Tissues

1995 • 118 citations

Cloning and nucleotide sequence of a full-length cDNA for human liver γ-glutamylcysteine synthetase

1992 • 118 citations

Extracellular glutathione and γ-glutamyl transpeptidase prevent H2O2-induced injury by 2,3-dimethoxy-1,4-naphthoquinone

1993 • 98 citations

Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan.

1995 • 97 citations

Regulation of rat glutathione S-transferase Ya subunit gene expression. DNA-protein interaction at the antioxidant responsive element.

1992 • 96 citations

Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content

1991 • 82 citations

Effect of superoxide dismutase on the autoxidation of substituted hydro- and semi-naphthoquinones

1990 • 80 citations

Modulation of γ-Glutamylcysteine Synthetase Large Subunit mRNA Expression by Butylated Hydroxyanisole

1994 • 66 citations

The toxicity of menadione (2-methyl-1,4-naphthoquinone) and two thioether conjugates studied with isolated renal epithelial cells

1991 • 60 citations

Influence of cumene hydroperoxide and 4-hydroxynonenal on the glutathione metabolism during in vitro ageing of human skin fibroblasts

1987 • 56 citations

Mapping of the Glutamate-Cysteine Ligase Catalytic Subunit Gene (GLCLC) to Human Chromosome 6p12 and Mouse Chromosome 9D-E and of the Regulatory Subunit Gene (GLCLR) to Human Chromosome 1p21-p22 and Mouse Chromosome 3H1-3

1995 • 51 citations

Detection of a nuclear protein which binds specifically to the antioxidant responsive element (ARE) of the human NAD(P)H:quinone oxidoreductase gene

1994 • 48 citations

Increase in γ-Glutamylcysteine Synthetase Activity as a Mechanism for Butylated Hydroxyanisole-Mediated Elevation of Hepatic Glutathione

1994 • 43 citations

Isolation of cells that retain differentiated functions in vitro: properties of clonally isolated type II alveolar pneymonocytes.

1976 • 22 citations