Gene Regulation by Reactive Oxygen Species

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Protein Oxidation and Aging

1992 • 2,687 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Oxygen Radicals and Human Disease

1987 • 1,854 citations

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

1983 • 1,808 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

OXIDATION OF FREE AMINO ACIDS AND AMINO ACID RESIDUES IN PROTEINS BY RADIOLYSIS AND BY METAL-CATALYZED REACTIONS

1993 • 1,377 citations

Microsomal Heme Oxygenase

1969 • 1,348 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

How to Characterize a Biological Antioxidant

1990 • 943 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide.

1979 • 907 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Oxygen radicals and the nervous system

1985 • 822 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

The biochemical basis of the NADPH oxidase of phagocytes

1993 • 631 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

INDUCIBLE DNA REPAIR SYSTEMS

1985 • 586 citations

A role for oxygen radicals as second messengers

1991 • 494 citations

Differential induction of heat shock, SOS, and oxidation stress regulons and accumulation of nucleotides in Escherichia coli

1987 • 492 citations

YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides.

1994 • 472 citations

Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins.

1986 • 442 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

1995 • 409 citations

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

1993 • 406 citations

A Tyr/Ser protein phosphatase encoded by vaccinia virus

1991 • 403 citations

Distinct Mechanisms for Regulation of the Interleukin-8 Gene Involve Synergism and Cooperativity between C/EBP and NF-κB

1993 • 400 citations

Detection of superoxide generated by endothelial cells.

1984 • 398 citations

Regulation of interleukin 8 gene expression by oxidant stress.

1993 • 395 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

An introduction to the free radical hypothesis in Parkinson's disease

1992 • 385 citations

The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage

1993 • 384 citations

Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: A mechanism for differential promoter selection

1994 • 379 citations

Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.

1990 • 343 citations

soxR, a locus governing a superoxide response regulon in Escherichia coli K-12

1990 • 341 citations

The tumore suppressor p53

1993 • 336 citations

An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein.

1994 • 331 citations

Induction of Ferritin Synthesis by Oxidative Stress

1995 • 321 citations

Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.

1990 • 309 citations

Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1983 • 309 citations

Role of Cysteine Residues in Regulation of p53 Function

1995 • 301 citations

Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial cells

1990 • 286 citations

The effect of some carbonyl compounds on rat liver glutathione levels

1970 • 264 citations

UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase.

1993 • 262 citations

An emerging family of dual specificity MAP kinase phosphatases

1995 • 256 citations

Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B.

1993 • 254 citations

Low levels of reactive oxygen species as modulators of cell function

1995 • 250 citations

X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates.

1994 • 247 citations

Mutational analysis of the redox-sensitive transcriptional regulator OxyR: regions important for oxidation and transcriptional activation

1995 • 245 citations

Redox status of cells influences constitutive or induced NF-kappa B translocation and HIV long terminal repeat activity in human T and monocytic cell lines.

1992 • 242 citations

A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress

1995 • 242 citations

A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress

1989 • 240 citations

cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.

1992 • 234 citations

Identification of a superoxide-generating NADPH oxidase system in human fibroblasts

1991 • 233 citations

Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.

1992 • 232 citations

Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts.

1987 • 225 citations

Mechanism of c-fos induction by active oxygen.

1992 • 224 citations

Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression.

1995 • 222 citations

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.

1994 • 220 citations

Hydrogen peroxide or heat shock induces resistance to hydrogen peroxide in Chinese hamster fibroblasts

1987 • 217 citations

Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

1994 • 212 citations

The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, ac-jun homologue, is involved in oxygen metabolism

1992 • 209 citations

Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions

1976 • 202 citations

Identification and molecular analysis of oxyR-regulated promoters important for the bacterial adaptation to oxidative stress

1989 • 198 citations

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

1992 • 195 citations

Activation of the cryptic DNA binding function of mutant forms of p53

1993 • 190 citations

Endonuclease IV of Escherichia coli is induced by paraquat.

1987 • 188 citations

Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines.

1990 • 187 citations

Activation of the gadd153 promoter by genotoxic agents: a rapid and specific response to DNA damage.

1992 • 175 citations

The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.

1992 • 174 citations

Induction of superoxide dismutase in Escherichia coli by heat shock.

1987 • 173 citations

Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation.

1993 • 172 citations

Superoxide anion release by human endothelial cells: Synergism between a phorbol ester and a calcium ionophore

1986 • 165 citations

Characterization of the DNA-Binding Properties of the Early Growth Response-1 (Egr-1) Transcription Factor: Evidence for Modulation by a Redox Mechanism

1993 • 163 citations

Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1985 • 158 citations

Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents.

1985 • 157 citations

In vitro DNA binding activity of Fos/Jun and BZLF1 but not C/EBP is affected by redox changes.

1991 • 156 citations

The DNA‐Binding Efficiency of Sp1 is Affected by Redox Changes

1994 • 156 citations

Oxidative Stress Induces Activation of a Cytosolic Protein Responsible for Control of Iron Uptake

1995 • 146 citations

Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile.

1987 • 146 citations

Tandem double CC-->TT mutations are produced by reactive oxygen species.

1993 • 141 citations

Transcriptional and posttranscriptional regulation of manganese superoxide dismutase biosynthesis in Escherichia coli, studied with operon and protein fusions

1988 • 139 citations

Thiols, Thiol Depletion, and Thermosensitivity

1983 • 132 citations

Isolation, characterization and chromosomal localization of the human GADD153 gene

1992 • 130 citations

Reduction of a conserved Cys is essential for Myb DNA-binding

1992 • 129 citations

The yeast DNA polymerase I transcript is regulated in both the mitotic cell cycle and in meiosis and is also induced after DNA damage

1987 • 129 citations

Sp1 DNA binding efficiency is highly reduced in nuclear extracts from aged rat tissues.

1992 • 128 citations

bcl-2 in cancer, development and apoptosis

1994 • 128 citations

The helix-loop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner.

1992 • 127 citations

Antioxidants Inhibit Stimulation of HIV Transcription

1993 • 114 citations

Thiol reducing reagents inhibit the heat shock response. Involvement of a redox mechanism in the heat shock signal transduction pathway.

1994 • 111 citations

The nucleotide sequence of the DNA ligase gene (CDC9) fromSaccharomyces cerevisiae: a gene which is cell-cycle regulated and induced in response to DNA damage

1985 • 110 citations

Function and induction of the microsomal heme oxygenase

1983 • 98 citations

Signal transduction and gene control

1991 • 94 citations

Redox manipulation of DNA binding activity and BuGR epitope reactivity of the glucocorticoid receptor

1991 • 90 citations

Differential induction of nuclear NF-kappa B by protein phosphatase inhibitors in primary and transformed human cells. Requirement for both oxidation and phosphorylation in nuclear translocation.

1993 • 89 citations

The DNA Binding Activity and the Dimerization Ability of the Thyroid Transcription Factor I Are Redox Regulated

1995 • 80 citations

A ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly.

1990 • 76 citations

N-Acetylcysteine enhances T cell functions and T cell growth in culture

1993 • 73 citations

Role of Zinc-Coordination and of the Glutathione Redox Couple in the Redox Susceptibility of Human Transcription Factor Sp1

1994 • 63 citations

Purification and characterization of thyroid transcription factor 2

1994 • 56 citations

Cooperative DNA Binding of the Human HoxB5 (Hox-2.1) Protein Is Under Redox Regulation In Vitro

1993 • 55 citations

DNA binding activity of the glucocorticoid receptor is sensitive to redox changes in intact cells

1995 • 55 citations

Human Fibroblasts Release Low Amounts of Reactive Oxygen Species in Response to the Potent Phagocyte Stimulants, Serum-Treated Zymosan, N-Formyl-methionyl-leucyl-phenylalanine, Leukotriene B₄or 12-O-Tetradecanoylphorbol 13-Acetate

1990 • 55 citations

Hydrogen peroxide activates immediate binding of a Drosophila factor to DNA heat‐shock regulatory element in vivo and in vitro

1990 • 48 citations

Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion

1994 • 48 citations

HIV-1 promoter activation following an oxidative stress mediated by singlet oxygen

1993 • 39 citations

Differentially expressed mRNAs as a consequence of oxidative stress in intact cells

1995 • 35 citations

Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro.

1993 • 30 citations