Regulation of the DNA binding activity of NF-κB

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide

1991 • 604 citations

Activation of HIV gene expression during monocyte differentiation by induction of NF-kB

1989 • 590 citations

Structure of NF-κB p50 homodimer bound to a κB site

1995 • 564 citations

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

1989 • 549 citations

Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system

1993 • 541 citations

Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins

1990 • 528 citations

Structure of the NF-κB p50 homodimer bound to DNA

1995 • 525 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers

1993 • 506 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

1990 • 469 citations

Dif, a dorsal-related gene that mediates an immune response in Drosophila

1993 • 464 citations

Isolation of a rel -related Human cDNAThat Potentially Encodes the 65-kD Subunit of NF-κB

1991 • 448 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB

1995 • 442 citations

The inducible transcription factor NF-κB: structure-function relationship of its protein subunits

1993 • 429 citations

Autoregulation of I kappa B alpha activity.

1994 • 419 citations

The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers.

1993 • 416 citations

Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65

1991 • 410 citations

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit

1992 • 399 citations

In Vitro Activation and Nuclear Translocation of NF-κB Catalyzed by Cyclic AMP-Dependent Protein Kinase and Protein Kinase C

1989 • 389 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.

1992 • 375 citations

Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B.

1992 • 373 citations

Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila

1987 • 366 citations

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

1995 • 351 citations

DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition.

1991 • 349 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.

1993 • 330 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro.

1988 • 309 citations

Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter.

1988 • 308 citations

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors.

1994 • 302 citations

Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel

1984 • 295 citations

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

1993 • 291 citations

NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit.

1991 • 287 citations

A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.

1992 • 281 citations

IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family

1992 • 274 citations

The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation.

1992 • 258 citations

Rel-Associated pp40: an Inhibitor of the Rel Family of Transcription Factors

1991 • 255 citations

Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB

1992 • 250 citations

Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B.

1995 • 243 citations

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

1992 • 243 citations

The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner.

1993 • 242 citations

Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells

1993 • 239 citations

The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.

1992 • 234 citations

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

1992 • 230 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

1989 • 220 citations

Blockage of NF-κB Signaling by Selective Ablation of an mRNA target by 2-5A Antisense Chimeras

1994 • 217 citations

The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation.

1991 • 210 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

Proteolytic degradation of MAD3 (IϰBα) and enhanced processing of the NF-ϰB precursor p105 are obligatory steps in the activation of NF-ϰB

1993 • 194 citations

Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.

1990 • 193 citations

Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1.

1993 • 189 citations

Autoregulation of the NF-kappa B transactivator RelA(p65) by multiple cytoplasmic inhibitors containing ankyrinmotifs.

1994 • 187 citations

Purification of KBF1, a common factor binding to both H-2 and beta 2-microglobulin enhancers.

1987 • 184 citations

Cytoplasmic retention, DNA binding and processing of the NF-kappa B p50 precursor are controlled by a small region in its C-terminus.

1991 • 182 citations

Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative.

1992 • 177 citations

The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.

1993 • 177 citations

Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein.

1989 • 176 citations

The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.

1992 • 174 citations

A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon.

1989 • 171 citations

Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB

1993 • 168 citations

The 65-kD subunit of NF-kappa B is a receptor for I kappa B and a modulator of DNA-binding specificity.

1990 • 167 citations

I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.

1992 • 167 citations

The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain.

1990 • 164 citations

In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB

1995 • 164 citations

Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex.

1992 • 155 citations

The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B.

1993 • 155 citations

NF-kappa B protein purification from bovine spleen: nucleotide stimulation and binding site specificity.

1988 • 148 citations

Transcriptional regulation of the HIV-1 promoter by NF-kappa B in vitro.

1992 • 146 citations

Role of cysteine₆₂in DNA recognition by the P50 subunit of NF-_xB

1993 • 142 citations

Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.

1991 • 138 citations

Inhibition of Protein Kinase C ζ Subspecies Blocks the Activation of an NF-Kappa B-Like Activity in Xenopus laevis Oocytes

1993 • 131 citations

A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.

1993 • 128 citations

N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65.

1993 • 126 citations

Domain Organization of IκBα and Sites of Interaction with NF-κB p65

1995 • 124 citations

The proto-oncogene bcl-3 encodes an I kappa B protein.

1992 • 116 citations

The NF-ϰB transcription factor induces DNA bending which is modulated by its 65-kD subunit

1990 • 109 citations

Inducible Degradation of IκBα In Vitro and In Vivo Requires the Acidic C-Terminal Domain of the Protein

1995 • 103 citations

Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A.

1992 • 86 citations

The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus.

1993 • 85 citations

The v-abl tyrosine kinase negatively regulates NF-kappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes.

1994 • 81 citations

Avian reticuloendotheliosis virus-transformed lymphoid cells contain multiple pp59v-rel complexes

1990 • 70 citations

Induction of nuclear factor-kappa B and the human immunodeficiency virus long terminal repeat by okadaic acid, a specific inhibitor of phosphatases 1 and 2A.

1990 • 67 citations

Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes.

1993 • 65 citations

Identification and purification of EBP1: a HeLa cell protein that binds to a region overlapping the 'core' of the SV40 enhancer.

1988 • 63 citations

Mutational analysis of the p50 subunit of NF-kappa B and inhibition of NF-kappa B activity by trans-dominant p50 mutants

1993 • 57 citations

Sequence requirement for specific interaction of an enhancer binding protein (EBP1) with DNA

1989 • 47 citations

The C terminus of the NF-χB p50 precursor and an IχB isoform contain transcription activation domains

1992 • 44 citations

I kappa B alpha can localize in the nucleus but shows no direct transactivation potential.

1993 • 41 citations

Interaction of enhancer-binding protein EBP1 (NF-kappa B) with the human immunodeficiency virus type 1 enhancer

1990 • 40 citations

Interaction of the C-terminal region of p105 with the nuclear localisation signal of p50 is required for inhinition of NF-ϰB binding activity

1993 • 34 citations

Evidence for a non-alpha-helical DNA-binding motif in the Rel homology region.

1994 • 32 citations

Cyclic AMP-Independent Activation of Transcription Factor NF-κB in HL60 Cells by Tumor Necrosis Factors α and β

1991 • 26 citations

Acquisition of NFKB1-Selective DNA Binding by Substitution of Four Amino Acid Residues from NFKB1 into RelA

1993 • 22 citations

Enhancer binding protein (EBP1) makes base and backbone contacts over one complete turn of the DNA double helix

1989 • 22 citations

Homodimer of p50 (NFκB1) does not introduce a substantial directed bend into DNA according to three different experimental assays

1995 • 14 citations

Cyclic AMP-independent activation of transcription factor NF-kappa B in HL60 cells by tumor necrosis factors alpha and beta.

1991 • 14 citations

DNA binding alters the protease susceptibility of the p50 subunit of NF-ϰB

1993 • 14 citations

Lipopolysaccharide-unresponsive mutant pre-B-cell lines blocked in NF-kappa B activation.

1990 • 13 citations

Acquisition of NFKB1-selective DNA binding by substitution of four amino acid residues from NFKB1 into RelA.

1993 • 10 citations