Oxidative stress and regulation of glutathione in lung inflammation

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma.

1996 • 1,370 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Adhesion molecules and inflammatory injury

1994 • 1,023 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Regulation of cellular glutathione

1989 • 851 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Normal alveolar epithelial lining fluid contains high levels of glutathione

1987 • 795 citations

Systemic oxidative stress in asthma, COPD, and smokers.

1996 • 781 citations

SYSTEMIC GLUTATHIONE DEFICIENCY IN SYMPTOM-FREE HIV-SEROPOSITIVE INDIVIDUALS

1989 • 725 citations

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion

1998 • 687 citations

Glutathione deficiency is associated with impaired survival in HIV disease

1997 • 665 citations

Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation

1999 • 578 citations

Oxidants in mitochondria: from physiology to diseases

1995 • 543 citations

Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns

1998 • 520 citations

Glutathione Deficiency in the Epithelial Lining Fluid of the Lower Respiratory Tract in Idiopathic Pulmonary Fibrosis

1989 • 472 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Role of transcription factors in inflammatory lung diseases

1998 • 455 citations

Functions of glutathione and glutathione disulfide in immunology and immunopathology

1994 • 446 citations

Constitutive and β-Naphthoflavone-induced Expression of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene Is Regulated by a Distal Antioxidant Response Element/TRE Sequence

1997 • 442 citations

Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema

1997 • 439 citations

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1997 • 432 citations

Transforming Growth Factor- β 1 in Asthma

1997 • 416 citations

Systemic deficiency of glutathione in cystic fibrosis

1993 • 388 citations

Role of membrane transport in metabolism and function of glutathione in mammals

1986 • 376 citations

Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro.

1996 • 375 citations

Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar.

1983 • 373 citations

Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.

1993 • 368 citations

Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death

1998 • 345 citations

Transport of cystine and cysteine in mammalian cells

1984 • 329 citations

Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine

1988 • 329 citations

The role of glutathione in the regulation of apoptosis

1999 • 325 citations

N-Acetylcysteine Enhances Recovery From Acute Lung Injury in Man

1994 • 322 citations

Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB

1999 • 319 citations

Transforming Growth Factor β₁and Recruitment of Macrophages and Mast Cells in Airways in Chronic Obstructive Pulmonary Disease

1998 • 307 citations

Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells

1994 • 303 citations

Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Plays a Major Role in Preventing Oxidative Injury to Cells

1999 • 296 citations

Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis.

1982 • 286 citations

Regulation of Ubiquitin-conjugating Enzymes by Glutathione Following Oxidative Stress

1997 • 283 citations

The Effect of Cigarette Smoking on Neutrophil Kinetics in Human Lungs

1989 • 281 citations

Antioxidative and Clinical Effects of High-doseN-Acetylcysteine in Fibrosing Alveolitis

1997 • 280 citations

Epithelial Permeability, Inflammation, and Oxidant Stress in the Air Spaces of Smokers

1999 • 278 citations

Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1

1994 • 274 citations

Glutathione permeability of CFTR

1998 • 266 citations

An Electrophile Responsive Element (EpRE) Regulates β-Naphthoflavone Induction of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene

1998 • 260 citations

Mitochondrial changes associated with glutathione deficiency

1995 • 246 citations

Translocation of intracellular glutathione to membrane-bound γ-glutamyl transpeptidase as a discrete step in the γ-glutamyl cycle: Glutathionuria after inhibition of transpeptidase

1979 • 244 citations

Neutrophil Depletion Inhibits Airway Hyperresponsiveness Induced by Ozone Exposure

1984 • 242 citations

N-Acetylcysteine and glutathione as inhibitors of tumor necrosis factor production

1992 • 238 citations

NF-IL6 and NF-kappa B in cytokine gene regulation.

1997 • 234 citations

The Level of Intracellular Glutathione Is a Key Regulator for the Induction of Stress-Activated Signal Transduction Pathways Including Jun N-Terminal Protein Kinases and p38 Kinase by Alkylating Agents

1997 • 226 citations

H2O2 and Tumor Necrosis Factor-α Induce Differential Binding of the Redox-responsive Transcription Factors AP-1 and NF-κB to the Interleukin-8 Promoter in Endothelial and Epithelial Cells

1998 • 224 citations

Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: report of a trial organized by the Swedish Society for Pulmonary Diseases.

1983 • 217 citations

Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene

1992 • 212 citations

Cooperativity between Oxidants and Tumor Necrosis Factor in the Activation of Nuclear Factor (NF)- κ B

1999 • 200 citations

Abnormal glutathione transport in cystic fibrosis airway epithelia

1999 • 199 citations

The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis

1994 • 197 citations

NF-IL6 and NF-κB in Cytokine Gene Regulation

1997 • 196 citations

Differential Effects of Transforming Growth Factor-β on the Expression of Collagenase-1 and Collagenase-3 in Human Fibroblasts

1998 • 192 citations

Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis

1991 • 192 citations

Oxidative stress: Role of mitochondria and protection by glutathione

1998 • 190 citations

Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304

1997 • 190 citations

Airway Inflammation in Smokers with Nonobstructive and Obstructive Chronic Bronchitis

1993 • 189 citations

Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression.

1994 • 188 citations

Glutathione S-transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease

1999 • 187 citations

Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis

1999 • 184 citations

EGF-Receptor Phosphorylation and Signaling Are Targeted by H₂O₂ Redox Stress

1998 • 183 citations

Activation of Heat Shock Factor by Alkylating Agents Is Triggered by Glutathione Depletion and Oxidation of Protein Thiols

1996 • 182 citations

Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studiesin vivoandin vitro

1999 • 180 citations

Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.

1991 • 179 citations

Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines.

1995 • 176 citations

Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress

1995 • 169 citations

Disruption of Redox Homeostasis in the Transforming Growth Factor-α/c-myc Transgenic Mouse Model of Accelerated Hepatocarcinogenesis

1998 • 168 citations

Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: Evidence for neutrophil-mediated hydroxylation, nitration, and chlorination

1999 • 167 citations

Elevation of intracellular glutathione content associated with mitogenic stimulation of quiescent fibroblasts

1986 • 167 citations

Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase.

1989 • 164 citations

gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells.

1994 • 163 citations

Increased Levels of Glutathione in Bronchoalveolar Lavage Fluid from Patients with Asthma

1993 • 161 citations

An investigation of the role of glutathione in increased epithelial permeability induced by cigarette smoke in vivo and in vitro.

1994 • 160 citations

Induction of γ‐glutamylcysteine synthetase by cigarette smoke is associated with AP‐1 in human alveolar epithelial cells

1996 • 155 citations

Mechanisms of Action of Glucocorticoids in Asthma

1996 • 154 citations

Transforming Growth Factor- β₁ Is a Potent Inhibitor of Glutathione Synthesis in the Lung Epithelial Cell Line A549: Transcriptional Effect on the GSH Rate-limiting Enzyme γ -Glutamylcysteine Synthetase

1997 • 153 citations

Role of Complement, Chemokines, & Regulatory Cytokines in Acute Lung Injury

1996 • 152 citations

Does N-Acetyl-L-Cysteine Influence Cytokine Response During Early Human Septic Shock?

1998 • 150 citations

Transcriptional Regulation of γ-Glutamylcysteine Synthetase-Heavy Subunit by Oxidants in Human Alveolar Epithelial Cells

1996 • 148 citations

Overexpression of γ-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1

1999 • 147 citations

Protection against paraquat-induced injury by exogenous GSH in pulmonary alveolar type II cells

1986 • 146 citations

Tumor Necrosis Factor Increases Hepatocellular Glutathione by Transcriptional Regulation of the Heavy Subunit Chain of γ-Glutamylcysteine Synthetase

1997 • 145 citations

Skeletal muscle glutathione is depleted in critically ill patients

1997 • 142 citations

Regulation of transforming growth factor beta1 by nitric oxide.

1999 • 142 citations

Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue.

1994 • 141 citations

Increased Transcription of the Regulatory Subunit of γ-Glutamylcysteine Synthetase in Rat Lung Epithelial L2 Cells Exposed to Oxidative Stress or Glutathione Depletion

1997 • 141 citations

Neutrophils cause oxidative DNA damage in alveolar epithelial cells

1999 • 140 citations

Genetics and pulmonary medicine bullet 9: Molecular genetics of chronic obstructive pulmonary disease

1999 • 139 citations

Long Exposure to High Glucose Concentration Impairs the Responsive Expression of γ-Glutamylcysteine Synthetase by Interleukin-1β and Tumor Necrosis Factor-α in Mouse Endothelial Cells

1996 • 136 citations

The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: a role for γ‐glutamylcysteine synthetase and γ‐glutamyl transpeptidase

1999 • 135 citations

Molecular Mechanism of the Regulation of Glutathione Synthesis by Tumor Necrosis Factor-α and Dexamethasone in Human Alveolar Epithelial Cells

1999 • 134 citations

Molecular Mechanisms of Neutrophil-Endothelial Cell Adhesion Induced by Redox Imbalance

1999 • 134 citations

Genetic susceptibility to chronic obstructive pulmonary disease in Koreans: combined analysis of polymorphic genotypes for microsomal epoxide hydrolase and glutathione S-transferase M1 and T1

2000 • 133 citations

Thiols decrease human interleukin (IL) 4 production and IL-4-induced immunoglobulin synthesis.

1995 • 128 citations

Superoxide Mediates Cigarette Smoke-Induced Infiltration of Neutrophils into the Airways through Nuclear Factor- κ B Activation and IL-8 mRNA Expression in Guinea PigsIn Vivo

1999 • 126 citations

Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state.

1997 • 126 citations

Nitric Oxide-Dependent Induction of Glutathione Synthesis through Increased Expression of γ-Glutamylcysteine Synthetase

1998 • 125 citations

Homocysteine redox receptor and regulation of extracellular matrix components in vascular cells

1998 • 124 citations

Cytokine expression in chronic inflammatory disease

1995 • 122 citations

Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects

1999 • 121 citations

Mechanisms of cigarette smoke induced increased airspace permeability.

1996 • 120 citations

TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C

1995 • 118 citations

Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro

1997 • 117 citations

The Effect of Exposure to Ozone and Nitrogen Dioxide on the Airway Response of Atopic Asthmatics to Inhaled Allergen

1999 • 115 citations

Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells

1996 • 113 citations

Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis

1999 • 113 citations

Antioxidant gene expression in rat lung after exposure to cigarette smoke.

1998 • 112 citations

Concurrent Production of Reactive Oxygen and Nitrogen Species by Airway Epithelial Cells In Vitro

1998 • 111 citations

ENVIRONMENTAL PARTICULATE-MEDIATED CYTOKINE PRODUCTION IN LUNG EPITHELIAL CELLS (A549): ROLE OF PREEXISTING INFLAMMATION AND OXIDANT STRESS

1998 • 109 citations

OXIDATIVE STRESS AND PULMONARY INFLAMMATION: PHARMACOLOGICAL INTERVENTION WITH ANTIOXIDANTS

1999 • 108 citations

Regulation of human γ-glutamylcysteine synthetase: co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells

1997 • 108 citations

Extracellular metabolism of glutathione accounts for its disappearance from the basolateral circulation of the kidney.

1984 • 105 citations

Augmentation of glutathione in the fluid lining the epithelium of the lower respiratory tract by directly administering glutathione aerosol.

1990 • 104 citations

Potentiation of oxygen toxicity in rats by dietary protein or amino acid deficiency

1983 • 103 citations

Optimal NFκB Mediated Transcriptional Responses in Jurkat T Cells Exposed to Oxidative Stress Are Dependent on Intracellular Glutathione and Costimulatory Signals

1996 • 102 citations

Treatment With Glutathione Precursor Decreases Cytokine Activity

1999 • 102 citations

Smoking-Associated Mitochondrial DNA Mutations and Lipid Peroxidation in Human Lung Tissues

1998 • 101 citations

N-acetylcysteine inhibits human neutrophil and monocyte chemotaxis and oxidative metabolism

1988 • 101 citations

Exposure to Hyperoxia Decreases the Expression of Vascular Endothelial Growth Factor and Its Receptors in Adult Rat Lungs

1999 • 99 citations

Immunohistochemical detection of multidrug resistance protein in human lung cancer and normal lung.

1998 • 98 citations

Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan.

1995 • 97 citations

Up-regulation of glutathione synthesis in rat kidney by methyl mercury

1995 • 96 citations

γ-Glutamylcysteine synthetase: mRNA stabilization and independent subunit transcription by 4-hydroxy-2-nonenal

1998 • 95 citations

Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo.

1992 • 95 citations

Expression of Glutathione and γ-Glutamylcysteine Synthetase mRNA Is Jun Dependent

1997 • 92 citations

Cadmium resistance in A549 cells correlates with elevated glutathione content but not antioxidant enzymatic activities

1995 • 91 citations

Nuclear Factor Kappa B Dependent Induction of Gamma Glutamylcysteine Synthetase by Ionizing Radiation in T98G Human Glioblastoma Cells

1998 • 91 citations

Ethanol Ingestion Increases Activation of Matrix Metalloproteinases in Rat Lungs during Acute Endotoxemia

1999 • 90 citations

Oxidants/antioxidants in idiopathic pulmonary fibrosis.

1995 • 90 citations

Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat.

1991 • 90 citations

Bioavailability of dietary glutathione: effect on plasma concentration

1990 • 88 citations

Microsomal epoxide hydrolase genotypes and chronic obstructive pulmonary disease in Japanese.

2000 • 87 citations

Enhancement of glutathione levels in mouse peritoneal macrophages by sodium arsenite, cadmium chloride and glucose/glucose oxidase

1991 • 87 citations

Glutathione metabolism in resting and phagocytizing peritoneal macrophages.

1982 • 85 citations

Mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo

1999 • 85 citations

Stimulation of cystine uptake by nitric oxide: regulation of endothelial cell glutathione levels

1999 • 85 citations

Transient depletion of lung glutathione by diethylmaleate enhances oxygen toxicity

1985 • 83 citations

Heterogeneous expression and polymorphic genotype of glutathione S-transferases in human lung.

1994 • 83 citations

Effect of selenium on glutathione metabolism

1981 • 83 citations

Extracellular Glutathione Suppresses Human Lung Fibroblast Proliferation

1990 • 81 citations

Cellular glutathione turnover in vitro, with emphasis on type II pneumocytes

1997 • 81 citations

gamma-Glutamylcysteine synthetase and active transport of glutathione S-conjugate are responsive to heat shock in K562 erythroid cells.

1993 • 80 citations

Delayed Effects of NO₂Exposure on Alveolar Permeability and Glutathione Peroxidase in Healthy Humans

1992 • 79 citations

Apocynin increases glutathione synthesis and activates AP‐1 in alveolar epithelial cells

1999 • 79 citations

Fate of dietary glutathione: disposition in the gastrointestinal tract

1990 • 78 citations

Up-regulation of ?-glutamylcysteine synthetase activity in melphalan-resistant human multiple myeloma cells expressing increased glutathione levels

1994 • 77 citations

Nebulized Glutathione Induces Bronchoconstriction in Patients with Mild Asthma

1997 • 76 citations

Changes in Neutrophil Deformability following In Vitro Smoke Exposure: Mechanism and Protection

1992 • 75 citations

Hydrogen peroxide-induced epithelial injury: the protective role of intracellular nonprotein thiols (NPSH)

1998 • 75 citations

Electron-Spin Resonance Study of Mainstream and Sidestream Cigarette Smoke: Nature of the Free Radicals in Gas-Phase Smoke and in Cigarette Tar

1983 • 74 citations

Rat lung antioxidant enzyme induction by ozone

1991 • 73 citations

Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIV-infected patients

1997 • 73 citations

Glutathione transport system in human small intestine epithelial cells

1997 • 71 citations

Glutathione biosynthesis in the isolated perfused rat lung: utilization of extracellular glutathione

1984 • 71 citations

Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamylcysteine synthetase and increases intracellular glutathione levels.

1999 • 71 citations

Characterisation of γ‐glutamylcysteine synthethase‐heavy subunit promoter: a critical role for AP‐1

1998 • 70 citations

Genes, oxidative stress, and the risk of chronic obstructive pulmonary disease

1998 • 69 citations

Thiol Depletion Induces Apoptosis in Cultured Lung Fibroblasts

1999 • 68 citations

Effects of pyrrolidine dithiocarbamate on endothelial cells: protection against oxidative stress

1999 • 68 citations

Loss of suppression of GSH synthesis at low cell density in primary cultures of rat hepatocytes

1992 • 68 citations

Modulation of antioxidant enzymes, reactive oxygen species, and glutathione levels in manganese superoxide dismutase-overexpressing NIH/3T3 fibroblasts during the cell cycle

1998 • 68 citations

Modulation of endogenous glutathione availability

1999 • 67 citations

Glutathione Downregulates the Phosphorylation of IκB: Autoloop Regulation of the NF-κB-Mediated Expression of NF-κB Subunits by TNF-α in Mouse Vascular Endothelial Cells

1998 • 66 citations

Reduction-oxidation (redox) state regulation of extracellular matrix metalloproteinases and tissue inhibitors in cardiac normal and transformed fibroblast cells

1996 • 65 citations

Sulphur dioxide: A potent glutathione depleting agent

1996 • 64 citations

Transcriptional regulation of the heavy subunit chain of γ‐glutamylcysteine synthetase by ionizing radiation

1998 • 64 citations

Glutathione in bronchoalveolar lavage fluid from smokers is related to humoral markers of inflammatory cell activity

1989 • 63 citations

Hormonal and cell density regulation of hepatic gamma-glutamylcysteine synthetase gene expression.

1995 • 63 citations

Oral N-acetylcysteine reduces selected humoral markers of inflammatory cell activity in BAL fluid from healthy smokers: correlation to effects on cellular variables

1988 • 62 citations

Antioxidant Enzyme Regulation and Resistance to Oxidants of Human Bronchial Epithelial Cells Cultured under Hyperoxic Conditions

1998 • 61 citations

MRP is frequently expressed in human lung-cancer cell lines, in non-small-cell lung cancer and in normal lung

1996 • 61 citations

The Molecular Basis of a Case of γ-Glutamylcysteine Synthetase Deficiency

1999 • 61 citations

Expression of γ-glutamylcysteine synthetase (γ-GCS) and multidrug resistance-associated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT), genes correlates with exposure of human lung cancers to platinum drugs

1998 • 60 citations

Elevation of Glutathione Levels in Bovine Pulmonary Artery Endothelial Cells by N-Acetylcysteine

1992 • 58 citations

Localization of γ-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease

2000 • 58 citations

Protective role of glutathione synthesis in response to oxidized low density lipoprotein in human vascular endothelial cells

1999 • 56 citations

Regulation ofγ-glutamycysteine synthetase expression in response to oxidative stress

1999 • 56 citations

Frequent coexpression of MRP/GS-X pump and γ-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues

1998 • 56 citations

Heme Oxygenase-1 Gene Expression by a Glutathione Depletor, Phorone, Mediated through AP-1 Activation in Rats

1996 • 54 citations

Mitochondrial glutathione modulates TNF-α-induced endothelial cell dysfunction

1999 • 54 citations

Effect of hyperoxia on glutathione levels and glutamic acid uptake in endothelial cells

1987 • 53 citations

Lymphocyte Glutathione Levels in Children With Cystic Fibrosis

1999 • 52 citations

Effects of Low Protein Diets or Feed Restriction on Rat Lung Glutathione and Oxygen Toxicity

1985 • 52 citations

Mapping of the Glutamate-Cysteine Ligase Catalytic Subunit Gene (GLCLC) to Human Chromosome 6p12 and Mouse Chromosome 9D-E and of the Regulatory Subunit Gene (GLCLR) to Human Chromosome 1p21-p22 and Mouse Chromosome 3H1-3

1995 • 51 citations

Glutathione protects signal transduction in type II cells under oxidant stress

1994 • 51 citations

Nitric oxide increases cellular glutathione levels in rat lung fibroblasts.

1995 • 48 citations

Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[l,2-b]indole in mouse hepatoma cell lines

1994 • 48 citations

Influence of nitric oxide on the intracellular reduced glutathione pool: different cellular capacities and strategies to encounter nitric oxide–mediated stress

1999 • 47 citations

Oxidant stress and adult respiratory distress syndrome.

1990 • 46 citations

Correction of glutathione deficiency in the lower respiratory tract of HIV seropositive individuals by glutathione aerosol treatment.

1993 • 46 citations

Ozone-induced alterations in glutathione in lung subcompartments of rats and monkeys.

1996 • 45 citations

Involvement of an NAD(P)H oxidase-like enzyme in superoxide anion and hydrogen peroxide generation by rat type II cells

1997 • 44 citations

Reduction of Glutathione Is Associated with Growth Restriction and Enlargement of Bovine Pulmonary Artery Endothelial Cells Produced by Transforming Growth Factor-β₁

1992 • 44 citations

Increase in γ-Glutamylcysteine Synthetase Activity as a Mechanism for Butylated Hydroxyanisole-Mediated Elevation of Hepatic Glutathione

1994 • 43 citations

Attenuation by glutathione of hsp72 gene expression induced by cadmium in cisplatin-resistant human ovarian cancer cells

1999 • 43 citations

Glutathione and lymphocyte activation: a function of ageing and auto-immune disease.

1987 • 41 citations

Effect of the Mucoactive Drug Nacystelyn on the Respiratory Burst of Human Blood Polymorphonuclear Neutrophils

1997 • 40 citations

Glutathione depletion in epithelial lining fluid of lung allograft patients.

1996 • 40 citations

Deformability and CD11/CD18 expression of sequestered neutrophils in normal and inflamed lungs.

1995 • 39 citations

Posttranscriptional Regulation ofMRP/GS-XPump and γ-Glutamylcysteine Synthetase Expression by 1-(4-Amino-2-methyl-5-pyrimidinyl) methyl-3- (2-chloroethyl)-3-nitrosourea and by Cycloheximide in Human Glioma Cells

1997 • 38 citations

Lung Uptake of Liposome-entrapped Glutathione After Intratracheal Administration

1991 • 38 citations

N-acetylcysteine does not protect against type II cell injury after prolonged exposure to hyperoxia in rats

1997 • 37 citations

Assignment of the gene (GLCLC) that encodes the heavy subunit of γ-glutamylcysteine synthetase to human chromosome 6

1995 • 36 citations

Induction of cystine transport in bovine pulmonary artery endothelial cells by sodium arsenite

1992 • 36 citations

Glutathione transport by type II cells in perfused rat lung

1994 • 36 citations

Mechanisms of use of extracellular glutathione by lung epithelial cells and pulmonary artery endothelial cells.

1995 • 35 citations

Assignment of the human gene (GLCLR) that encodes the regulatory subunit of γ-glutamylcysteine synthetase to chromosome 1p21

1996 • 34 citations

NO₂-induced generation of extracellular reactive oxygen is mediated by epithelial lining layer antioxidants

1997 • 34 citations

Gene Transfer of Mitochondrially Targeted Glutathione Reductase Protects H441 Cells from t-Butyl Hydroperoxide–Induced Oxidant Stresses

1999 • 34 citations

Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of γ-glutamylcysteine synthetase, to chromosome band 6p12 and characterization of a polymorphic trinucleotide repeat within its 5’ untranslated region

1996 • 33 citations

Glutathione Localization and Distribution after Intratracheal Instillation: Implications for Treatment

1992 • 32 citations

Stimulation of glutathione synthesis in iron-loaded mice

1989 • 32 citations

A noninducible cystine transport system in rat alveolar type II cells

1995 • 32 citations

Identification ofcis-Acting DNA Elements of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene

1997 • 31 citations

Effects of Sulfur Dioxide Inhalation on Antioxidant Enzyme Activities in Rat Erythrocytes.

1998 • 30 citations

Thiol-disulfide effects on hepatic glutathione transport. Studies in cultured rat hepatocytes and perfused livers.

1993 • 28 citations

Aqueous cigarette tar extracts damage human alpha-1-proteinase inhibitor

1991 • 28 citations

Glutathione, cell proliferation, and 1,3-bis-(2-chloroethyl)-1-nitrosourea in K562 leukemia.

1993 • 28 citations

Modulation of ICAM-1 expression by extracellular glutathione in hyperoxia-exposed human pulmonary artery endothelial cells.

1996 • 26 citations

Metallothionein, glutathione, and cystine transport in pulmonary artery endothelial cells and NIH/3T3 cells

1998 • 24 citations

Up-regulation of Glutamate–Cysteine Ligase Gene Expression by Butylated Hydroxytoluene Is Mediated by Transcription Factor AP-1

1998 • 22 citations

Structure and refinement of the physical mapping of the γ-glutamylcysteine ligase regulatory subunit (GLCLR) gene to chromosome 1p22.1 within the critically deleted region of human malignant mesothelioma

1998 • 22 citations

H2O2 induces apoptosis in bovine tracheal epithelial cells in vitro

1999 • 22 citations

Cigarette smoke exposure causes constriction of rat lung

1999 • 21 citations

Glutathione Homeostasis in Human Hepatic Cells: Overexpression of γ-Glutamylcysteine Synthetase Gene in Cell Lines Resistant to Buthionine Sulfoximine, an Inhibitor of Glutathione Synthesis

1998 • 21 citations

Erythrocytes fail to induce glutathione in response to diethyl maleate or hyperoxia

1989 • 20 citations

Effects of sulfite on glutathione S-sulfonate and the glutathione status of lung cells

1989 • 20 citations

Messenger RNA levels of lung extracellular matrix proteins during ozone exposure

1994 • 20 citations

[Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression].

1998 • 20 citations

SUPPRESSION OF RAT AND MOUSE LYMPHOCYTE FUNCTION BY URBAN AIR PARTICULATES (OTTAWA DUST) IS REVERSED BY N-ACETYLCYSTEINE

2000 • 19 citations

Angiogenesis and cigarette smoking in squamous cell lung carcinomas: an immunohistochemical study of 28 cases.

1999 • 18 citations

[Mechanism of action of glucocorticoids in asthma].

1999 • 18 citations

Flow cytometric analysis of protein thiol groups in relation to the cell cycle and the intracellular content of glutathione in rat hepatocytes

1989 • 17 citations

Susceptibility of cultured rat hepatocytes to oxidative stress by peroxides and iron. The extracellular matrix affects the toxicity of tert -butyl hydroperoxide

1999 • 14 citations

Altered glutathione transferase levels in rat skin inflamed due to contact hypersensitivity: induction of the Alpha-class subunit 1

1998 • 13 citations

Attenuation of Oxidant‐Induced Lung Injury by the Synthetic Matrix Metalloproteinase Inhibitor BB‐3103

1999 • 12 citations

Modulation of Glutathione Synthetic Enzymes by Acidic Fibroblast Growth Factor

2000 • 12 citations

Regulation of γ‐glutamylcysteine synthetase activity by nerve growth factor

1996 • 12 citations

Investigation of the transport of intact glutathione in human and rat type II pneumocytes

1999 • 9 citations

The effect of prostaglandin E2 on cystine uptake and glutathione synthesis by human lung fibroblasts

1998 • 7 citations

Thiols Decrease Human IL-4 Production and IL-4-lnduced Immunoglobulin Synthesis

1997 • 3 citations

Phenobarbital prevents the inhibitory effects of tumor necrosis factor on glutathione-S-transferase mu in primary culture rat hepatocytes.

1998 • 3 citations