Regulation of nuclear factor-κB, activator protein-1, and glutathione levels by tumor necrosis factor-α and dexamethasone in alveolar epithelial cells

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1990 • 1,592 citations

Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma.

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Biologic and pharmacologic regulation of mammalian glutathione synthesis

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Oxidative stress and nuclear factor-κB activation

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AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

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SYSTEMIC GLUTATHIONE DEFICIENCY IN SYMPTOM-FREE HIV-SEROPOSITIVE INDIVIDUALS

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Is NF‐κB the sensor of oxidative stress?

1999 • 669 citations

Gene expression and the thiol redox state

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Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases

1996 • 491 citations

Glutathione Deficiency in the Epithelial Lining Fluid of the Lower Respiratory Tract in Idiopathic Pulmonary Fibrosis

1989 • 472 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Role of transcription factors in inflammatory lung diseases

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Functions of glutathione and glutathione disulfide in immunology and immunopathology

1994 • 446 citations

Constitutive and β-Naphthoflavone-induced Expression of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene Is Regulated by a Distal Antioxidant Response Element/TRE Sequence

1997 • 442 citations

Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease

1999 • 427 citations

Role of oxidants/antioxidants in smoking-induced lung diseases

1996 • 414 citations

NF-κB as a primary regulator of the stress response

1999 • 407 citations

Systemic deficiency of glutathione in cystic fibrosis

1993 • 388 citations

The role of glutathione in the regulation of apoptosis

1999 • 325 citations

Transcription factors and asthma

1998 • 324 citations

4-Hydroxy-2-nonenal-mediated Impairment of Intracellular Proteolysis during Oxidative Stress

1999 • 320 citations

Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells

1994 • 303 citations

Redox regulation of c‐Jun DNA binding by reversible S‐glutathiolation

1999 • 285 citations

Epithelial Permeability, Inflammation, and Oxidant Stress in the Air Spaces of Smokers

1999 • 278 citations

Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1

1994 • 274 citations

An Electrophile Responsive Element (EpRE) Regulates β-Naphthoflavone Induction of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene

1998 • 260 citations

Nuclear Factor-κB–Dependent Induction of Interleukin-8 Gene Expression by Tumor Necrosis Factor : Evidence for an Antioxidant Sensitive Activating Pathway Distinct From Nuclear Translocation

1999 • 238 citations

The Level of Intracellular Glutathione Is a Key Regulator for the Induction of Stress-Activated Signal Transduction Pathways Including Jun N-Terminal Protein Kinases and p38 Kinase by Alkylating Agents

1997 • 226 citations

H2O2 and Tumor Necrosis Factor-α Induce Differential Binding of the Redox-responsive Transcription Factors AP-1 and NF-κB to the Interleukin-8 Promoter in Endothelial and Epithelial Cells

1998 • 224 citations

Redox regulation of ubiquitin‐conjugating enzymes: mechanistic insights using the thiol‐specific oxidant diamide

1998 • 209 citations

Cytokine-mediated Induction of Ceramide Production Is Redox-sensitive

1998 • 206 citations

Oxidized Glutathione Is Increased in the Alveolar Fluid of Patients with the Adult Respiratory Distress Syndrome

1993 • 206 citations

Cooperativity between Oxidants and Tumor Necrosis Factor in the Activation of Nuclear Factor (NF)- κ B

1999 • 200 citations

Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304

1997 • 190 citations

Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression.

1994 • 188 citations

Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis

1999 • 184 citations

Modulation of transcription factor NFχB activity by intracellular glutathione levels and by variations of the extracellular cysteine supply

1995 • 168 citations

Oxidative Stress Induces NF- B Nuclear Translocation Without Degradation of I B

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Increased Levels of Glutathione in Bronchoalveolar Lavage Fluid from Patients with Asthma

1993 • 161 citations

Cell type-specific role for reactive oxygen species in nuclear factor-kappaB activation by Interleukin-1

2000 • 158 citations

Transcriptional Regulation of γ-Glutamylcysteine Synthetase-Heavy Subunit by Oxidants in Human Alveolar Epithelial Cells

1996 • 148 citations

Overexpression of γ-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1

1999 • 147 citations

Tumor Necrosis Factor Increases Hepatocellular Glutathione by Transcriptional Regulation of the Heavy Subunit Chain of γ-Glutamylcysteine Synthetase

1997 • 145 citations

Influenza Virus-induced NF-κB-dependent Gene Expression Is Mediated by Overexpression of Viral Proteins and Involves Oxidative Radicals and Activation of IκB Kinase

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Long Exposure to High Glucose Concentration Impairs the Responsive Expression of γ-Glutamylcysteine Synthetase by Interleukin-1β and Tumor Necrosis Factor-α in Mouse Endothelial Cells

1996 • 136 citations

Molecular Mechanism of the Regulation of Glutathione Synthesis by Tumor Necrosis Factor-α and Dexamethasone in Human Alveolar Epithelial Cells

1999 • 134 citations

Redox regulation of TNF signaling

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1995 • 128 citations

Regulation of Hepatic Glutathione Synthesis

1998 • 123 citations

Redox regulation of chemokine receptor expression

2000 • 114 citations

OXIDATIVE STRESS AND PULMONARY INFLAMMATION: PHARMACOLOGICAL INTERVENTION WITH ANTIOXIDANTS

1999 • 108 citations

Optimal NFκB Mediated Transcriptional Responses in Jurkat T Cells Exposed to Oxidative Stress Are Dependent on Intracellular Glutathione and Costimulatory Signals

1996 • 102 citations

γ-Glutamylcysteine synthetase: mRNA stabilization and independent subunit transcription by 4-hydroxy-2-nonenal

1998 • 95 citations

Expression of Glutathione and γ-Glutamylcysteine Synthetase mRNA Is Jun Dependent

1997 • 92 citations

Nuclear Factor Kappa B Dependent Induction of Gamma Glutamylcysteine Synthetase by Ionizing Radiation in T98G Human Glioblastoma Cells

1998 • 91 citations

Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat.

1991 • 90 citations

Increased gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity.

1996 • 74 citations

Induction of c-fos and c-jun gene expression by phenolic antioxidants.

1993 • 72 citations

How Does Superoxide Dismutase Protect Against Tumor Necrosis Factor: A Hypothesis Informed by Effect of Superoxide on “FREE” Iron

1997 • 71 citations

Characterisation of γ‐glutamylcysteine synthethase‐heavy subunit promoter: a critical role for AP‐1

1998 • 70 citations

A Functional Role of IκB-ε in Endothelial Cell Activation

2000 • 67 citations

Glutathione Downregulates the Phosphorylation of IκB: Autoloop Regulation of the NF-κB-Mediated Expression of NF-κB Subunits by TNF-α in Mouse Vascular Endothelial Cells

1998 • 66 citations

Protective Effects of Heme Oxygenase-1 against Oxidant-Induced Injury in the Cultured Human Tracheal Epithelium

1999 • 59 citations

The role of superoxide radical in TNF-alpha induced NF-kappaB activation.

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Glutathione protects signal transduction in type II cells under oxidant stress

1994 • 51 citations

Influence of the cellular redox state on NF-?B-regulated gene expression

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Induction of c-fos and c-jun gene expression by phenolic antioxidants

1993 • 40 citations

Glutathione depletion in epithelial lining fluid of lung allograft patients.

1996 • 40 citations

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1999 • 35 citations

Effect of pregnenolone-16α-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice

1992 • 32 citations

Identification ofcis-Acting DNA Elements of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene

1997 • 31 citations

The Role of Glutathione in Chronic Adaptation to Oxidative Stress: Studies in a Normal Rat Kidney Epithelial (NRK52E) Cell Model of Sustained Upregulation of Glutathione Biosynthesis

1999 • 31 citations

Intracellular glutathione redox status modulates MCP-1 expression in pulmonary granulomatous vasculitis.

1999 • 27 citations

Nuclear Factor-κB–Dependent Induction of Interleukin-8 Gene Expression by Tumor Necrosis Factor : Evidence for an Antioxidant Sensitive Activating Pathway Distinct From Nuclear Translocation

1999 • 25 citations

Lung glutathione and oxidative stress

1999 • 13 citations