Redox-Regulated Recruitment of the Transcriptional Coactivators CREB-Binding Protein and SRC-1 to Hypoxia-Inducible Factor 1α

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer

1997 • 1,655 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.

1996 • 1,095 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

Luciferase reporter gene vectors for analysis of promoters and enhancers.

1988 • 1,016 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

An essential role for p300/CBP in the cellular response to hypoxia

1996 • 780 citations

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

1999 • 744 citations

GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.

1996 • 702 citations

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1998 • 653 citations

Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

1998 • 639 citations

Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation

1998 • 609 citations

Co-activators and co-repressors in the integration of transcriptional responses

1998 • 606 citations

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

1997 • 605 citations

RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2

1997 • 585 citations

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300

1999 • 583 citations

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

1995 • 578 citations

GRIP1, a Transcriptional Coactivator for the AF-2 Transactivation Domain of Steroid, Thyroid, Retinoid, and Vitamin D Receptors

1997 • 572 citations

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

1995 • 534 citations

Oxygen(es) and the hypoxia-inducible factor-1.

1997 • 518 citations

The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways

1998 • 516 citations

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1997 • 514 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

1996 • 453 citations

Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor

1996 • 449 citations

CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.

1996 • 414 citations

Activation of hypoxia-inducible factor 1α: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

1997 • 406 citations

p300 is a component of an estrogen receptor coactivator complex.

1996 • 399 citations

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1999 • 387 citations

TRAM-1, A Novel 160-kDa Thyroid Hormone Receptor Activator Molecule, Exhibits Distinct Properties from Steroid Receptor Coactivator-1

1997 • 380 citations

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.

1994 • 351 citations

Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators

1998 • 337 citations

Isoforms of steroid receptor co-activator 1differ in their ability to potentiate transcription by the oestrogen receptor

1998 • 321 citations

The acetyltransferase activity of CBP stimulates transcription

1998 • 265 citations

Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.

1994 • 241 citations

Steroid Receptor Coactivator-1 Interacts with the p50 Subunit and Coactivates Nuclear Factor κB-mediated Transactivations

1998 • 232 citations

Adaptor-mediated Recruitment of RNA Polymerase II to a Signal-dependent Activator

1996 • 199 citations

CBP/p300 Functions as a Possible Transcriptional Coactivator of Ah Receptor Nuclear Translocator (Arnt)

1997 • 194 citations

Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation.

1995 • 190 citations

Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.

1995 • 187 citations

Transcription factors 2: helix-loop-helix.

1995 • 149 citations

A Nuclear Localization Signal of Human Aryl Hydrocarbon Receptor Nuclear Translocator/Hypoxia-inducible Factor 1β Is a Novel Bipartite Type Recognized by the Two Components of Nuclear Pore-targeting Complex

1997 • 121 citations

Constitutive Function of the Basic Helix-Loop-Helix/PAS Factor Arnt.

1995 • 99 citations

An Additional Region of Coactivator GRIP1 Required for Interaction with the Hormone-binding Domains of a Subset of Nuclear Receptors

1999 • 90 citations

Eukaryotic GST fusion vector for the study of protein-protein associations in vivo: application to interaction of ATFa with Jun and Fos.

1995 • 48 citations

Deleted Work

1955 • 0 citations