A Redox Mechanism Controls Differential DNA Binding Activities of Hypoxia-inducible Factor (HIF) 1α and the HIF-like Factor

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

1998 • 2,392 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

HIF-1alpha is required for solid tumor formation and embryonic vascularization

1998 • 1,567 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Oxygen radicals and signaling

1998 • 1,163 citations

Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation

1998 • 1,162 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

1997 • 1,004 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Regulation of activity of the transcription factor GATA-1 by acetylation

1998 • 686 citations

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1998 • 653 citations

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1998 • 638 citations

Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α

1998 • 633 citations

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

1997 • 605 citations

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300

1999 • 583 citations

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1997 • 514 citations

Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

1997 • 510 citations

Chaperone Activity with a Redox Switch

1999 • 509 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor

1996 • 449 citations

Crystal structure of a novel human peroxidase enzyme at 2.0 Å resolution

1998 • 370 citations

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels

1997 • 368 citations

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.

1994 • 351 citations

Control of cell lineage-specific development and transcription by bHLH-PAS proteins

1998 • 347 citations

Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide

1999 • 295 citations

Bridge over Troubled Waters

1999 • 294 citations

Oxygen-regulated and Transactivating Domains in Endothelial PAS Protein 1: Comparison with Hypoxia-inducible Factor-1α

1999 • 241 citations

Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.

1994 • 241 citations

Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

1998 • 230 citations

Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer

1998 • 228 citations

Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis

1998 • 205 citations

Direct Association with Thioredoxin Allows Redox Regulation of Glucocorticoid Receptor Function

1999 • 205 citations

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

1993 • 192 citations

Identification of Vascular Endothelial Growth Factor (VEGF) Receptor-2 (Flk-1) Promoter/Enhancer Sequences Sufficient for Angioblast and Endothelial Cell-Specific Transcription in Transgenic Mice

1999 • 183 citations

Redox-dependent Regulation of Nuclear Import of the Glucocorticoid Receptor

1999 • 178 citations

Electrostatic influence of local cysteine environments on disulfide exchange kinetics

1981 • 167 citations

Modifications of Vectors pEF-BOS, pcDNA1 and pcDNA3 Result in Improved Convenience and Expression

1996 • 159 citations

Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism.

1993 • 154 citations

Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers

1998 • 152 citations

The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal

1996 • 148 citations

Functional modulation of estrogen receptor by redox state with reference to thioredoxin as a mediator

1997 • 133 citations

Escape from redox regulation enhances the transforming activity of Fos.

1993 • 119 citations

Prolyl Isomerases and Nuclear Function

1998 • 117 citations

Role of the PAS Domain in Regulation of Dimerization and DNA Binding Specificity of the Dioxin Receptor

1998 • 113 citations

Redox Potential Controls the Structure and DNA Binding Activity of the Paired Domain

1998 • 107 citations

An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures

1994 • 102 citations

Subunit Association and DNA Binding Activity of the Heterotrimeric Transcription Factor NF-Y Is Regulated by Cellular Redox

1996 • 97 citations

Ref-1 Controls Pax-8 DNA-Binding Activity

1998 • 89 citations

[39] Glucocorticoid receptor thiols andsteroid-binding activity

1995 • 46 citations

Hydrogen peroxide stabilizes the steroid-binding state of rat liver glucocorticoid receptors by promoting disulfide bond formation

1988 • 41 citations

Increase in Ref-1 mRNA and Protein by Thyrotropin in Rat Thyroid FRTL-5 Cells

1997 • 38 citations

Deleted Work

1955 • 0 citations

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