Nuclear Factor Kappa B: Important Transcription Factor and Therapeutic Target

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms

1998 • 1,516 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Signal transduction through NF-κB

1998 • 1,103 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

The Role of Nuclear Factor- κ B in Cytokine Gene Regulation

1997 • 948 citations

Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice

1996 • 839 citations

Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.

1996 • 795 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

1994 • 661 citations

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

1997 • 611 citations

Activation of HIV gene expression during monocyte differentiation by induction of NF-kB

1989 • 590 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

1997 • 576 citations

Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.

1995 • 487 citations

NF-κB as a Frequent Target for Immunosuppressive and Anti-Inflammatory Molecules**This article was accepted for publication on 27 September 1996.

1997 • 472 citations

Role of NFkappaB in the mortality of sepsis.

1997 • 464 citations

NF-κB and Rel Proteins in Innate Immunity

1995 • 435 citations

Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression.

1994 • 423 citations

Autoregulation of I kappa B alpha activity.

1994 • 419 citations

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

1995 • 354 citations

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

1994 • 334 citations

Molecular mechanisms of anti‐inflammatory action of glucocorticoids

1996 • 313 citations

Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration.

1996 • 308 citations

IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.

1995 • 304 citations

Nuclear factor–kB in rheumatoid synovium. Localization of P50 and P65

1995 • 289 citations

Nuclear factor-kappa B is activated in alveolar macrophages from patients with acute respiratory distress syndrome

1996 • 288 citations

REL/NF-κB/IκB Story

1995 • 278 citations

Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation

1994 • 275 citations

The NF-κB/Rel and IκB gene families: mediators of immune response and inflammation

1996 • 265 citations

Aspirin Inhibits Nuclear Factor–κB Mobilization and Monocyte Adhesion in Stimulated Human Endothelial Cells

1995 • 260 citations

Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids

1995 • 254 citations

Involvement of nuclear factor kB in the regulation of cyclooxygenase‐2 expression by interleukin‐1 in rheumatoid synoviocytes

1997 • 252 citations

NF-IL6 and NF-kappa B in cytokine gene regulation.

1997 • 234 citations

Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B.

1996 • 228 citations

Glucocorticoid-mediated Repression of NFκB Activity in Endothelial Cells Does Not Involve Induction of IκBα Synthesis

1996 • 204 citations

NF-IL6 and NF-κB in Cytokine Gene Regulation

1997 • 196 citations

Manipulation of Distinct NFκB Proteins Alters Interleukin-1β-induced Human Rheumatoid Synovial Fibroblast Prostaglandin E2 Formation

1996 • 173 citations

Mechanisms of Action of Glucocorticoids in Asthma

1996 • 154 citations

Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF‐κB activation

1997 • 154 citations

Glucocorticoids inhibit E-selectin expression by targeting NF-kappaB and not ATF/c-Jun.

1997 • 140 citations

The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.

1994 • 140 citations

Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.

1994 • 137 citations

Induction of cytokines and ICAM-1 by proinflammatory cytokines in primary rheumatoid synovial fibroblasts and inhibition by N-acetyl-L-cysteine and aspirin

1996 • 121 citations

Modification of vascular responses in xenotransplantation: Inflammation and apoptosis

1997 • 111 citations

Regulation of granulocyte-macrophage colony-stimulating factor and E- selectin expression in endothelial cells by cyclosporin A and the T- cell transcription factor NFAT

1995 • 99 citations

FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells.

1995 • 93 citations

Novel insight into molecular mechanism of endotoxin shock: biochemical analysis of LPS receptor signaling in a cell-free system targeting NF-κB and regulation of cytokine production/action through β2 integrin in vivo

1996 • 90 citations

Molecular chaperones and the biosynthesis of antigen receptors

1995 • 85 citations

Transcriptional Regulation of Endothelial Cell Adhesion Molecules: A Dominant Role for NF-κB

1995 • 84 citations

The Allergen Der p1 Induces NF-kB Activation through Interference with IkBα Function in Asthmatic Bronchial Epithelial Cells

1997 • 79 citations

Cyclosporin A interferes with the inducible degradation of NF-xB inhibitors, but not with the processing of p105/NF-xB1 in T cells

1997 • 79 citations

Deoxyspergualin inhibits kappa light chain expression in 70Z/3 pre-B cells by blocking lipopolysaccharide-induced NF-kappa B activation.

1995 • 77 citations

The Effect of Dexamethasone on the Expression of Activated NF-κB in Adjuvant Arthritis

1997 • 75 citations

Suppression of NFκB activation and NFκB‐dependent gene expression by tepoxalin, a dual inhibitor of cyclooxygenase and 5‐lipoxygenase

1995 • 75 citations

The NF-kappaB transcription factor in oncogenesis.

1996 • 75 citations

Molecular Mechanisms of Immunosuppression and Anti-inflammatory Activities by Glucocorticoids

1996 • 72 citations

Cyclosporine a inhibits tissue factor expression in monocytes/macrophages

1996 • 71 citations

Multi-Step Activation of NF-κB/Rel Transcription Factors

1995 • 71 citations

Characterization of IκB Kinases

1996 • 69 citations

Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway.

1994 • 67 citations

Regulation of the DNA binding activity of NF-κB

1995 • 66 citations

Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers.

1993 • 62 citations

Interleukin 1β-Induced Expression of Nitric Oxide Synthase in Rat Renal Mesangial Cells Is Suppressed by Cyclosporin A

1995 • 51 citations

Elucidating the Mechanism of Action of the Immunosuppressant 15-Deoxyspergualin

1995 • 48 citations

Cyclosporin A sensitivity of the NF-χB site of the IL2Rα promoter in untransformed murine T cells

1994 • 44 citations

The Actions of NSAIDs

1991 • 34 citations

Tumour Necrosis Factor α Causes Retention of Activated Glucocorticoid Receptor within the Cytoplasm of A549 Cells

1996 • 33 citations

Deoxyspergualin: mechanism of action and pharmacokinetics.

1996 • 31 citations

Accommodation of xenografts: Expression of “protective genes” in endothelial and smooth muscle cells

1997 • 31 citations

Aspirin inhibits expression of the interleukin-1β-inducible group II phospholipase A₂

1996 • 27 citations

Cytokine-modulating activity of tepoxalin, a new potential antirheumatic

1995 • 21 citations

Kappa B binding proteins are constitutively expressed in an IL-2 autocrine human T cell line.

1991 • 20 citations

TEPOXALIN, A NOVEL IMMUNOMODULATORY COMPOUND, SYNERGIZES WITH CSA IN SUPPRESSION OF GRAFT-VERSUS-HOST REACTION AND ALLOGENEIC SKIN GRAFT REJECTION

1995 • 7 citations