2-mercaptoethanol restores the ability of nuclear factor κB (NF κB) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NFκB by PDTC

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1976 • 225,752 citations

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

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Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

1992 • 1,524 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

Dithiocarbamates Induce Apoptosis in Thymocytes by Raising the Intracellular Level of Redox-active Copper

1995 • 280 citations

Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1

1994 • 274 citations

α-Lipoic acid is a potent inhibitor of NF-κB activation in human T cells

1992 • 232 citations

Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IκBα: a Mechanism for NF-κB Activation

1993 • 223 citations

Effects of oxidants and antioxidants on nuclear factor ϰB activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals

1995 • 206 citations

Proteolytic degradation of MAD3 (IϰBα) and enhanced processing of the NF-ϰB precursor p105 are obligatory steps in the activation of NF-ϰB

1993 • 194 citations

Role of cysteine₆₂in DNA recognition by the P50 subunit of NF-_xB

1993 • 142 citations

Towards an understanding of the signal transduction pathways for interleukin 1

1995 • 123 citations

Studies into the Effect of the Tyrosine Kinase Inhibitor Herbimycin A on NF-κB Activation in T Lymphocytes EVIDENCE FOR COVALENT MODIFICATION OF THE p50 SUBUNIT

1995 • 118 citations

The Role of Reactive Oxygen Intermediates in Osteoclastic Bone Resorption

1995 • 111 citations

Pyrrolidine Dithiocarbamate Prevents IL-1-Induced Nitric Oxide Synthase mRNA, but Not Superoxide Dismutase mRNA, in Insulin Producing Cells

1995 • 46 citations

Regulation of inducible nitric oxide synthase expression in rat mesangial cells and isolated glomeruli

1995 • 43 citations

Covalent cross-linking of proteins by carbon disulfide

1992 • 28 citations

Inhibition of NFkappaB activity by oxidative processes in intact cells — mechanism of action of pyrolidine dithiocarbamate and diamide

1996 • 10 citations

Mechanism of NFκB activation by interleukin-1 and tumour necrosis factor in endothelial cells

1996 • 8 citations