One-Electron Reduction of Chromium(VI) by α-Lipoic Acid and Related Hydroxyl Radical Generation, dG Hydroxylation and Nuclear Transcription Factor-κB Activation

Oxidative mechanisms in the toxicity of metal ions

1995 • 4,127 citations

Alpha-lipoic acid as a biological antioxidant

1995 • 1,920 citations

Spin Trapping: ESR parameters of spin adducts 1474 1528V

1987 • 1,660 citations

Mechanisms of Chromium Carcinogenicity and Toxicity

1993 • 537 citations

Genotoxicity of chromium compounds. A review

1990 • 451 citations

Dihydrolipoic acid—a universal antioxidant both in the membrane and in the aqueous phase

1992 • 363 citations

Metal carcinogenesis: Mechanistic implications

1992 • 348 citations

Detection and identification of short-lived free radicals by an electron spin resonance trapping technique

1968 • 337 citations

Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide.

1990 • 336 citations

Carcinogenicity and mutagenicity of chromium

1980 • 305 citations

Lipoic and Dihydrolipoic Acids as Antioxidants. a Critical Evaluation

1994 • 301 citations

Possible Role of Oxidative Damage in Metal-Induced Carcinogenesis

1995 • 261 citations

Metabolism of the carcinogen chromate by cellular constituents

2007 • 260 citations

Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant?

1995 • 243 citations

Thioctic Acid and Dihydrolipoic Acid are Novel Antioxidants Which Interact With Reactive Oxygen Species

1991 • 239 citations

Reduction of Chromium(VI) by Ascorbate Leads to Chromium-DNA Binding and DNA Strand Breaks in Vitro

1995 • 232 citations

α-Lipoic acid is a potent inhibitor of NF-κB activation in human T cells

1992 • 232 citations

The role of oxidative damage in metal carcinogenicity

1991 • 212 citations

The role of oxidative processes in metal carcinogenesis

1991 • 209 citations

Toxicity and Mutagenicity of Hexavalent Chromium on Salmonella typhimurium

1977 • 207 citations

On the hydroxyl radical formation in the reaction between hydrogen peroxide and biologically generated chromium(V) species

1990 • 184 citations

Role of physiological antioxidants in chromium(VI)-induced cellular injury

1992 • 182 citations

Chromium (V) and hydroxyl radical formation during the glutathione reductase-catalyzed reduction of chromium (VI)

1989 • 174 citations

Reaction of Chromium(VI) with Ascorbate Produces Chromium(V), Chromium(IV), and Carbon-Based Radicals

1994 • 169 citations

Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on α-tocopherol

1989 • 166 citations

Reaction of Cr(VI) with ascorbate and hydrogen peroxide generates hydroxyl radicals and causes DNA damage: role of a Cr(IV)-mediated Fenton-like reaction

1994 • 160 citations

Genetic effects of chromium compounds

1983 • 146 citations

Evidence for a fenton-type mechanism for the generation of .OH radicals in the reduction of Cr(VI) in cellular media

1990 • 138 citations

Role of cellular antioxidants in metal-induced damage

1994 • 135 citations

Chromium(VI)-induced nuclear factor-кB activation in intact cells via free radical reactions

1995 • 134 citations

Is there a role for reactive oxygen species in the mechanism of chromium(VI) carcinogenesis?

1991 • 118 citations

ESR evidence for superoxide, hydroxyl radicals and singlet oxygen produced from hydrogen peroxide and nickel(II) complex of glycylglycyl-L-histidine

1989 • 111 citations

Reaction of chromium(VI) with hydrogen peroxide in the presence of glutathione: reactive intermediates and resulting DNA damage

1990 • 106 citations

Chromosomal aberrations and morphological transformation in hamster embryonic cells treated with potassium dichromate in vitro

1977 • 105 citations

Effect of ascorbic acid on DNA damage, cytotoxicity, glutathione reductase, and formation of paramagnetic chromium in Chinese hamster V-79 cells treated with sodium chromate(VI)

1991 • 97 citations

On the mechanism of the chromate reduction by glutathione: ESR evidence for the glutathionyl radical and an isolable Cr(V) intermediate

1988 • 92 citations

Chromium-induced cross-linking of nuclear proteins and DNA.

1985 • 92 citations

Nitroxide Radical Adducts in Biology: Chemistry, Applications, and Pitfalls

1989 • 88 citations

Chromosomal aberrations and sister-chromatid exchanges in Chinese hamster cells treated in vitro with hexavalent chromium compounds

1979 • 84 citations

Elucidation of Antioxidant Activity of α-Lipoic Acid Toward Hydroxyl Radical

1995 • 73 citations

Characterization of a silencer regulatory element in the human interferon-gamma promoter.

1994 • 62 citations

NF-κB Sites Function as Positive Regulators of Expression of the Translocated c-myc Allele in Burkitt's Lymphoma

1994 • 54 citations

Chromate-mediated free radical generation from cysteine, penicillamine, hydrogen peroxide, and lipid hydroperoxides

1994 • 52 citations

Chromium Toxicity and Carcinogenesis

1990 • 49 citations

The Reductive Conversion of Chromium(VI) by Ascorbate Gives Rise to Apurinic/Apyrimidinic Sites in Isolated DNA

1995 • 20 citations