Inflammation and the Regulation of Glutathione Level in Lung Epithelial Cells

GLUTATHIONE

1983 • 5,487 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma.

1996 • 1,370 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Adhesion molecules and inflammatory injury

1994 • 1,023 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

1991 • 906 citations

Induction of nitric oxide synthase in asthma

1993 • 852 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Systemic oxidative stress in asthma, COPD, and smokers.

1996 • 781 citations

Glutathione: Toxicological Implications

1990 • 750 citations

Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.

1975 • 729 citations

Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation

1999 • 578 citations

Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.

1989 • 577 citations

Oxidants in mitochondria: from physiology to diseases

1995 • 543 citations

Glutathione Deficiency in the Epithelial Lining Fluid of the Lower Respiratory Tract in Idiopathic Pulmonary Fibrosis

1989 • 472 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Role of transcription factors in inflammatory lung diseases

1998 • 455 citations

Functions of glutathione and glutathione disulfide in immunology and immunopathology

1994 • 446 citations

Transforming Growth Factor- β 1 in Asthma

1997 • 416 citations

Role of oxidants/antioxidants in smoking-induced lung diseases

1996 • 414 citations

Glutathione deficiency and human immunodeficiency virus infection

1992 • 409 citations

Systemic deficiency of glutathione in cystic fibrosis

1993 • 388 citations

Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro.

1996 • 375 citations

Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.

1993 • 368 citations

Glutathione monoethyl ester: Preparation, uptake by tissues, and conversion to glutathione

1985 • 349 citations

Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death

1998 • 345 citations

Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine

1988 • 329 citations

N-Acetylcysteine Enhances Recovery From Acute Lung Injury in Man

1994 • 322 citations

Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells

1994 • 303 citations

Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Plays a Major Role in Preventing Oxidative Injury to Cells

1999 • 296 citations

[29] Glutaredoxin

1995 • 284 citations

Regulation of Ubiquitin-conjugating Enzymes by Glutathione Following Oxidative Stress

1997 • 283 citations

The Effect of Cigarette Smoking on Neutrophil Kinetics in Human Lungs

1989 • 281 citations

Antioxidative and Clinical Effects of High-doseN-Acetylcysteine in Fibrosing Alveolitis

1997 • 280 citations

Epithelial Permeability, Inflammation, and Oxidant Stress in the Air Spaces of Smokers

1999 • 278 citations

Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1

1994 • 274 citations

An Electrophile Responsive Element (EpRE) Regulates β-Naphthoflavone Induction of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene

1998 • 260 citations

Mitochondrial changes associated with glutathione deficiency

1995 • 246 citations

Antioxidant response element

1994 • 245 citations

Neutrophil Depletion Inhibits Airway Hyperresponsiveness Induced by Ozone Exposure

1984 • 242 citations

N-Acetylcysteine and glutathione as inhibitors of tumor necrosis factor production

1992 • 238 citations

α-Lipoic Acid: A Metabolic Antioxidant and Potential Redox Modulator of Transcription

1996 • 237 citations

NF-IL6 and NF-kappa B in cytokine gene regulation.

1997 • 234 citations

The Level of Intracellular Glutathione Is a Key Regulator for the Induction of Stress-Activated Signal Transduction Pathways Including Jun N-Terminal Protein Kinases and p38 Kinase by Alkylating Agents

1997 • 226 citations

A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress

1994 • 221 citations

Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits.

1984 • 213 citations

Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene

1992 • 212 citations

Oxidized Glutathione Is Increased in the Alveolar Fluid of Patients with the Adult Respiratory Distress Syndrome

1993 • 206 citations

The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis

1994 • 197 citations

NF-IL6 and NF-κB in Cytokine Gene Regulation

1997 • 196 citations

Differential Effects of Transforming Growth Factor-β on the Expression of Collagenase-1 and Collagenase-3 in Human Fibroblasts

1998 • 192 citations

Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis

1991 • 192 citations

Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304

1997 • 190 citations

Oxidative stress: Role of mitochondria and protection by glutathione

1998 • 190 citations

Low-dose N-Acetylcysteine Protects Rats against Endotoxin-mediated Oxidative Stress, But High-dose Increases Mortality

1998 • 189 citations

Airway Inflammation in Smokers with Nonobstructive and Obstructive Chronic Bronchitis

1993 • 189 citations

Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression.

1994 • 188 citations

Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis

1999 • 184 citations

EGF-Receptor Phosphorylation and Signaling Are Targeted by H₂O₂ Redox Stress

1998 • 183 citations

Activation of Heat Shock Factor by Alkylating Agents Is Triggered by Glutathione Depletion and Oxidation of Protein Thiols

1996 • 182 citations

Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studiesin vivoandin vitro

1999 • 180 citations

Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.

1991 • 179 citations

Disruption of Redox Homeostasis in the Transforming Growth Factor-α/c-myc Transgenic Mouse Model of Accelerated Hepatocarcinogenesis

1998 • 168 citations

An investigation of the role of glutathione in increased epithelial permeability induced by cigarette smoke in vivo and in vitro.

1994 • 160 citations

Mechanisms of Action of Glucocorticoids in Asthma

1996 • 154 citations

Transforming Growth Factor- β₁ Is a Potent Inhibitor of Glutathione Synthesis in the Lung Epithelial Cell Line A549: Transcriptional Effect on the GSH Rate-limiting Enzyme γ -Glutamylcysteine Synthetase

1997 • 153 citations

Role of Complement, Chemokines, & Regulatory Cytokines in Acute Lung Injury

1996 • 152 citations

v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway

1995 • 151 citations

The DNA Binding Activity of C/EBP Transcription Factors Is Regulated in the G1 Phase of the Hepatocyte Cell Cycle

1995 • 151 citations

Transcriptional Regulation of γ-Glutamylcysteine Synthetase-Heavy Subunit by Oxidants in Human Alveolar Epithelial Cells

1996 • 148 citations

Tumor Necrosis Factor Increases Hepatocellular Glutathione by Transcriptional Regulation of the Heavy Subunit Chain of γ-Glutamylcysteine Synthetase

1997 • 145 citations

Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue.

1994 • 141 citations

Increased Transcription of the Regulatory Subunit of γ-Glutamylcysteine Synthetase in Rat Lung Epithelial L2 Cells Exposed to Oxidative Stress or Glutathione Depletion

1997 • 141 citations

Long Exposure to High Glucose Concentration Impairs the Responsive Expression of γ-Glutamylcysteine Synthetase by Interleukin-1β and Tumor Necrosis Factor-α in Mouse Endothelial Cells

1996 • 136 citations

Cellular glutathione and thiol measurements from surgically resected human lung tumor and normal lung tissue.

1991 • 135 citations

The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: a role for γ‐glutamylcysteine synthetase and γ‐glutamyl transpeptidase

1999 • 135 citations

Molecular Mechanism of the Regulation of Glutathione Synthesis by Tumor Necrosis Factor-α and Dexamethasone in Human Alveolar Epithelial Cells

1999 • 134 citations

Molecular Mechanisms of Neutrophil-Endothelial Cell Adhesion Induced by Redox Imbalance

1999 • 134 citations

Superoxide Mediates Cigarette Smoke-Induced Infiltration of Neutrophils into the Airways through Nuclear Factor- κ B Activation and IL-8 mRNA Expression in Guinea PigsIn Vivo

1999 • 126 citations

Nitric Oxide-Dependent Induction of Glutathione Synthesis through Increased Expression of γ-Glutamylcysteine Synthetase

1998 • 125 citations

Cytokine expression in chronic inflammatory disease

1995 • 122 citations

Mechanisms of cigarette smoke induced increased airspace permeability.

1996 • 120 citations

Cloning and Sequencing of the cDNA for the Light Subunit of Human Liver γ-Glutamylcysteine Synthetase and Relative RNA Levels for Heavy and Light Subunits in Human Normal Tissues

1995 • 118 citations

Concurrent Production of Reactive Oxygen and Nitrogen Species by Airway Epithelial Cells In Vitro

1998 • 111 citations

Cloning of a Carboxyl-terminal Isoform of the Prostanoid FP Receptor

1997 • 110 citations

ENVIRONMENTAL PARTICULATE-MEDIATED CYTOKINE PRODUCTION IN LUNG EPITHELIAL CELLS (A549): ROLE OF PREEXISTING INFLAMMATION AND OXIDANT STRESS

1998 • 109 citations

Regulation of human γ-glutamylcysteine synthetase: co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells

1997 • 108 citations

The participation of hydroperoxides and oxygen radicals in the control of prostaglandin synthesis.

1983 • 107 citations

Augmentation of glutathione in the fluid lining the epithelium of the lower respiratory tract by directly administering glutathione aerosol.

1990 • 104 citations

Regulation of γ-glutamylcysteine synthetase by protein phosphorylation

1996 • 102 citations

Smoking-Associated Mitochondrial DNA Mutations and Lipid Peroxidation in Human Lung Tissues

1998 • 101 citations

Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan.

1995 • 97 citations

Expression of Glutathione and γ-Glutamylcysteine Synthetase mRNA Is Jun Dependent

1997 • 92 citations

Cadmium resistance in A549 cells correlates with elevated glutathione content but not antioxidant enzymatic activities

1995 • 91 citations

Oxidants/antioxidants in idiopathic pulmonary fibrosis.

1995 • 90 citations

Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat.

1991 • 90 citations

Glutathione and inflammatory disorders of the lung

1991 • 88 citations

Cellular glutathione turnover in vitro, with emphasis on type II pneumocytes

1997 • 81 citations

Glutathione metabolism in patients with non-small cell lung cancers.

1997 • 81 citations

gamma-Glutamylcysteine synthetase and active transport of glutathione S-conjugate are responsive to heat shock in K562 erythroid cells.

1993 • 80 citations

Apocynin increases glutathione synthesis and activates AP‐1 in alveolar epithelial cells

1999 • 79 citations

The Epithelium as a Target of Glucocorticoid Action in the Treatment of Asthma

1996 • 77 citations

Nebulized Glutathione Induces Bronchoconstriction in Patients with Mild Asthma

1997 • 76 citations

Hydrogen peroxide-induced epithelial injury: the protective role of intracellular nonprotein thiols (NPSH)

1998 • 75 citations

Changes in Neutrophil Deformability following In Vitro Smoke Exposure: Mechanism and Protection

1992 • 75 citations

Electron-Spin Resonance Study of Mainstream and Sidestream Cigarette Smoke: Nature of the Free Radicals in Gas-Phase Smoke and in Cigarette Tar

1983 • 74 citations

Increased gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity.

1996 • 74 citations

Characterisation of γ‐glutamylcysteine synthethase‐heavy subunit promoter: a critical role for AP‐1

1998 • 70 citations

Glutathione Downregulates the Phosphorylation of IκB: Autoloop Regulation of the NF-κB-Mediated Expression of NF-κB Subunits by TNF-α in Mouse Vascular Endothelial Cells

1998 • 66 citations

Dietary Sulphur Amino Acid Adequacy Influences Glutathione Synthesis and Glutathione-Dependent Enzymes during the Inflammatory Response to Endotoxin and Tumour Necrosis Factor-α in Rats

1997 • 66 citations

Transcriptional regulation of the heavy subunit chain of γ‐glutamylcysteine synthetase by ionizing radiation

1998 • 64 citations

Glutathione in bronchoalveolar lavage fluid from smokers is related to humoral markers of inflammatory cell activity

1989 • 63 citations

Oral N-acetylcysteine reduces selected humoral markers of inflammatory cell activity in BAL fluid from healthy smokers: correlation to effects on cellular variables

1988 • 62 citations

Antioxidant Enzyme Regulation and Resistance to Oxidants of Human Bronchial Epithelial Cells Cultured under Hyperoxic Conditions

1998 • 61 citations

The Responses of Glutathione and Antioxidant Enzymes to Hyperoxia in Developing Lung

1985 • 60 citations

Oxidant-Protease Interaction in the Lung

1996 • 56 citations

Protective role of glutathione synthesis in response to oxidized low density lipoprotein in human vascular endothelial cells

1999 • 56 citations

Mitochondrial glutathione modulates TNF-α-induced endothelial cell dysfunction

1999 • 54 citations

Identification of an important cysteine residue in human glutamate–cysteine ligase catalytic subunit by site-directed mutagenesis

1998 • 49 citations

Nitric oxide increases cellular glutathione levels in rat lung fibroblasts.

1995 • 48 citations

Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[l,2-b]indole in mouse hepatoma cell lines

1994 • 48 citations

Involvement of an NAD(P)H oxidase-like enzyme in superoxide anion and hydrogen peroxide generation by rat type II cells

1997 • 44 citations

Reduction of Glutathione Is Associated with Growth Restriction and Enlargement of Bovine Pulmonary Artery Endothelial Cells Produced by Transforming Growth Factor-β₁

1992 • 44 citations

Increase in γ-Glutamylcysteine Synthetase Activity as a Mechanism for Butylated Hydroxyanisole-Mediated Elevation of Hepatic Glutathione

1994 • 43 citations

Physiologic and toxicologic responses of alveolar type II cells

1990 • 41 citations

Inducible expression of the γ-glutamylcysteine synthetase light subunit by t-butylhydroquinone in HepG2 cells is not dependent on an antioxidant- responsive element

1998 • 40 citations

Deformability and CD11/CD18 expression of sequestered neutrophils in normal and inflamed lungs.

1995 • 39 citations

Glutathione transport by type II cells in perfused rat lung

1994 • 36 citations

Mechanisms of use of extracellular glutathione by lung epithelial cells and pulmonary artery endothelial cells.

1995 • 35 citations

Gene Transfer of Mitochondrially Targeted Glutathione Reductase Protects H441 Cells from t-Butyl Hydroperoxide–Induced Oxidant Stresses

1999 • 34 citations

Evidence for a multi‐domain structure for hormone‐sensitive lipase

1996 • 33 citations

Identification ofcis-Acting DNA Elements of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene

1997 • 31 citations

Ascorbic acid inhibition of alpha-adrenergic receptor binding

1986 • 29 citations

Plasma levels of glutathione, α-tocopherol and lipid peroxides in polytraumatized patients; evidence for a stimulating effect of TNF α on glutathione synthesis

1998 • 28 citations

Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of γ-glutamylcysteine synthetase and increases intracellular glutathione levels

1999 • 27 citations

COMPARISON OF PLASMA REDUCED GLUTATHIONE AND OXIDIZED GLUTATHIONE WITH LUNG AND LIVER TISSUE OXIDANT AND ANTIOXIDANT ACTIVITY DURING ACUTE INFLAMMATION

1994 • 26 citations

L-2-Oxothiazolidine-4-carboxylate protects cultured endothelial cells against hyperoxia-induced injury

1988 • 23 citations

Oxygen-induced Lung Damage: Relationship to Lung Mitochondrial Glutathione Levels

1992 • 21 citations

Angiogenesis and cigarette smoking in squamous cell lung carcinomas: an immunohistochemical study of 28 cases.

1999 • 18 citations

Elicitation of Cultivated Plant Cells as a Tool in Biotechnology and Basic Biochemistry

1996 • 10 citations

The effect of prostaglandin E2 on cystine uptake and glutathione synthesis by human lung fibroblasts

1998 • 7 citations