Redox Regulation of Lipopolysaccharide(LPS)-Induced Interleukin-8 (IL-8) Gene Expression Mediated by NFκB and AP-1 in Human Astrocytoma U373 Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

[70] Determination of glutathione and glutathione disulfide in biological samples

1985 • 2,678 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

1995 • 1,436 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.

1987 • 983 citations

The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it

1992 • 925 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Soluble CD14 participates in the response of cells to lipopolysaccharide.

1992 • 695 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia

1996 • 639 citations

Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1).

1987 • 613 citations

Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes

1995 • 538 citations

Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8.

1989 • 515 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.

1994 • 478 citations

Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene.

1992 • 450 citations

The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species

1984 • 410 citations

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

1995 • 409 citations

Regulation of interleukin 8 gene expression by oxidant stress.

1993 • 395 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.

1995 • 304 citations

New insights into the cause of Parkinson's disease

1992 • 272 citations

Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells.

1994 • 264 citations

転写因子NF‐κBとAP‐1の活性化に及ぼすチオレドキシンと抗酸化剤の異なった効果

1994 • 259 citations

Reporter constructs with low background activity utilizing the cat gene

1992 • 240 citations

Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

1994 • 212 citations

Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide.

1993 • 211 citations

Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events

1991 • 202 citations

IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line.

1991 • 166 citations

Signal transduction for nuclear factor-kappa B activation. Proposed location of antioxidant-inhibitable step.

1994 • 158 citations

Cell-free pool of CD14 mediates activation of transcription factor NF-kappa B by lipopolysaccharide in human endothelial cells.

1993 • 135 citations

Hypoxia up-regulates the activity of a novel erythropoietin mRNA binding protein.

1991 • 117 citations

[48] N-acetylcysteine

1994 • 115 citations

Suppression of Nerve Growth Factor-induced Neuronal Differentiation of PC12 Cells

1996 • 90 citations

Lipopolysaccharide Activates Transcription of the Heme Oxygenase Gene in Mouse M1 Cells Through Oxidative Activation of Nuclear Factor κB

1996 • 76 citations

Molecular biology of aging

1989 • 74 citations

Inhibition by N‐acetyl‐<scp>l</scp>‐cysteine of interleukin‐6 mRNA induction and activation of NFκB by tumor necrosis factor α in a mouse fibroblastic cell line, Balb/3T3

1994 • 50 citations

Use of a Marked Erythropoietin Gene for Investigation of Its Cis-acting Elements

1995 • 31 citations