Induction of TNFalpha in macrophages by vanadate is dependent on activation of transcription factor NF-kappaB and free radical reactions.

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

1995 • 923 citations

Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.

1990 • 900 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells

1997 • 466 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

Cytokine Production by Human Airway Epithelial Cells after Exposure to an Air Pollution Particle Is Metal-Dependent

1997 • 447 citations

Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes.

1993 • 304 citations

Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.

1990 • 283 citations

Tumor Necrosis Factor Alpha Gene Regulation in Activated T Cells Involves ATF-2/Jun and NFATp

1996 • 252 citations

Regulation of Tumor Necrosis Factor Alpha Transcription in Macrophages: Involvement of Four κΒ-Like Motifs and of Constitutive and Inducible Forms of NF-κB

1990 • 230 citations

The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.

1992 • 210 citations

Effects of oxidants and antioxidants on nuclear factor ϰB activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals

1995 • 206 citations

Cell-Type-Specific Regulation of the Human Tumor Necrosis Factor Alpha Gene in B Cells and T Cells by NFATp and ATF-2/JUN

1996 • 189 citations

C/EBP beta regulation of the tumor necrosis factor alpha gene.

1994 • 173 citations

The Nuclear Factor YY1 Suppresses the Human Gamma Interferon Promoter through Two Mechanisms: Inhibition of AP1 Binding and Activation of a Silencer Element

1996 • 171 citations

Induction of Oxidative Stress by Okadaic Acid Is Required for Activation of Transcription Factor NF-κB

1995 • 170 citations

Reactive oxygen intermediates as regulators of TNF-alpha production in rat lung inflammation induced by silica.

1996 • 162 citations

Signal transduction for nuclear factor-kappa B activation. Proposed location of antioxidant-inhibitable step.

1994 • 158 citations

Role of Oxidative Stress in the Action of Vanadium Phosphotyrosine Phosphatase Inhibitors

1997 • 138 citations

In Vitro Human Monocyte Response To Wear Particles Of Titanium Alloy Containing Vanadium Or Niobium

1997 • 135 citations

Chromium(VI)-induced nuclear factor-кB activation in intact cells via free radical reactions

1995 • 134 citations

The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription.

1994 • 134 citations

Characterization of an Krox-24/Egr-1-responsive element in the human tumor necrosis factor promoter

1994 • 126 citations

Regulation of the Human TNF Promoter by the Transcription Factor Ets

1995 • 116 citations

Vanadium as a modulator of cellular regulatory cascades and oncogene expression

1993 • 102 citations

Activation of HIV-1 Long Terminal Repeat Transcription and Virus Replication via NF-κB-dependent and -independent Pathways by Potent Phosphotyrosine Phosphatase Inhibitors, the Peroxovanadium Compounds

1997 • 86 citations

Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene

1991 • 86 citations

The role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NF-kappaB.

1999 • 82 citations

Pleural macrophage recruitment and activation in asbestos-induced pleural injury.

1997 • 80 citations

Vanadium-Induced Chemokine mRNA Expression and Pulmonary Inflammation

1996 • 77 citations

Regulation of bone cells by particle-activated mononuclear phagocytes

1997 • 70 citations

Characterization of the Human Granulocyte-Macrophage Colony-Stimulating Factor Gene Promoter: an AP1 Complex and an Sp1-Related Complex Transactivate the Promoter Activity That Is Suppressed by a YY1 Complex

1996 • 70 citations

Characterization of a silencer regulatory element in the human interferon-gamma promoter.

1994 • 62 citations

Constitutive and Interleukin-1 (IL-1)-Inducible Factors Interact with the IL-1-Responsive Element in the IL-6 Gene

1990 • 58 citations

Hydroxyl Radical Generation in the Nadh/Microsomal Reduction of vanadate

1992 • 56 citations

Role of hydroxyl radical in silica-induced NF-kappa B activation in macrophages.

1998 • 55 citations

Application of Transcriptional and Posttranscriptional Reporter Constructs to the Analysis of Tumor Necrosis Factor Gene Regulation

1992 • 47 citations

Antisense Inhibition of Silica-induced Tumor Necrosis Factor in Alveolar Macrophages

1997 • 30 citations

Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-4 Differentially Regulate the Human Tumor Necrosis Factor-α Promoter Region

1995 • 26 citations

One-Electron Reduction of Vanadium(V) by Flavoenzymes/NADPH

1993 • 25 citations

Immunotoxicity of In vitro vanadium exposures: Effects on interleukin-1, tumor necrosis factor-α, and prostaglandin E2 production by WEHI-3 macrophages

1993 • 23 citations

Modulation of TNF-alpha secretions by alveolar macrophages and blood monocytes after soot-particle or asbestos fibre exposure.

1996 • 4 citations