NF-κB and the immune response

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Toll-like receptor control of the adaptive immune responses

2004 • 4,092 citations

Signaling to NF-κB

2004 • 3,768 citations

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

2004 • 3,766 citations

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

2004 • 3,745 citations

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

2006 • 3,607 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

2005 • 3,059 citations

The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

2005 • 2,449 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

Resolution of inflammation: the beginning programs the end

2005 • 2,353 citations

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

2005 • 2,312 citations

Introduction to NF-κB: players, pathways, perspectives

2006 • 2,115 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

2005 • 2,043 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

2002 • 1,919 citations

Recognition of single-stranded RNA viruses by Toll-like receptor 7

2004 • 1,777 citations

VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

2005 • 1,761 citations

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

2000 • 1,644 citations

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

2003 • 1,625 citations

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

2005 • 1,602 citations

RANK is essential for osteoclast and lymph node development

1999 • 1,417 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

Cell Type-Specific Involvement of RIG-I in Antiviral Response

2005 • 1,311 citations

Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

2002 • 1,309 citations

Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells

2002 • 1,305 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

2001 • 1,231 citations

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling

2002 • 1,224 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Discrimination of bacterial lipoproteins by Toll-like receptor 6

2001 • 1,222 citations

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

2003 • 1,203 citations

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

2003 • 1,189 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

2003 • 1,137 citations

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

2006 • 1,104 citations

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

2006 • 1,097 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

2001 • 1,048 citations

Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible toStaphylococcus aureusInfection

2000 • 1,046 citations

NODs: intracellular proteins involved in inflammation and apoptosis

2003 • 1,041 citations

TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

2003 • 1,023 citations

A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria

2004 • 1,013 citations

TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

2005 • 1,007 citations

Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

2000 • 1,002 citations

Requirement for NF-κB in osteoclast and B-cell development

1997 • 994 citations

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

2002 • 985 citations

Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response

2006 • 983 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN -β promoter

2004 • 947 citations

BAFF and APRIL: A Tutorial on B Cell Survival

2003 • 946 citations

Modulation of Akt kinase activity by binding to Hsp90

2000 • 942 citations

Essential function for the kinase TAK1 in innate and adaptive immune responses

2005 • 927 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation

2004 • 821 citations

Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis

1999 • 813 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

2001 • 807 citations

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

2002 • 803 citations

Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

2003 • 798 citations

Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling

2006 • 797 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

2005 • 755 citations

Possible new role for NF-κB in the resolution of inflammation

2001 • 741 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

2002 • 734 citations

Control of B-cell responses by Toll-like receptors

2005 • 732 citations

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

2004 • 719 citations

Organogenesis of lymphoid tissues

2003 • 716 citations

Baff Mediates Survival of Peripheral Immature B Lymphocytes

2000 • 705 citations

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

2005 • 705 citations

The TRAF6 Ubiquitin Ligase and TAK1 Kinase Mediate IKK Activation by BCL10 and MALT1 in T Lymphocytes

2004 • 674 citations

BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells

2002 • 674 citations

Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

2006 • 652 citations

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA

2005 • 649 citations

SOCS-1 Participates in Negative Regulation of LPS Responses

2002 • 636 citations

IκB kinase complexes: gateways to NF-κB activation and transcription

2006 • 628 citations

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

2005 • 625 citations

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

2005 • 624 citations

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

2002 • 619 citations

SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation

2002 • 618 citations

TACI-Ig Neutralizes Molecules Critical for B Cell Development and Autoimmune Disease

2001 • 611 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Achieving Stability of Lipopolysaccharide-Induced NF-κB Activation

2005 • 595 citations

Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite

2001 • 593 citations

SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling

2003 • 580 citations

Negative Regulation of Toll-like Receptor-mediated Signaling by Tollip

2002 • 574 citations

Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells

2001 • 571 citations

The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection

2004 • 563 citations

Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

2004 • 552 citations

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

2001 • 551 citations

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

1996 • 540 citations

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

2000 • 538 citations

An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways

2000 • 535 citations

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1 -deficient mouse embryonic fibroblasts

2003 • 524 citations

Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

2003 • 524 citations

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

2004 • 520 citations

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

2006 • 504 citations

Stimulus Specificity of Gene Expression Programs Determined by Temporal Control of IKK Activity

2005 • 504 citations

Mutations in the NF-κB signaling pathway: implications for human disease

2006 • 503 citations

A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation

2001 • 497 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

TLR2 is expressed on activated T cells as a costimulatory receptor

2004 • 471 citations

Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice

2000 • 469 citations

Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.

1996 • 464 citations

Recruitment of the IKK Signalosome to the p55 TNF Receptor

2000 • 457 citations

Regulation of the NF-κB-inducing Kinase by Tumor Necrosis Factor Receptor-associated Factor 3-induced Degradation

2004 • 449 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

RelB Is Essential for the Development of Myeloid-Related CD8α− Dendritic Cells but Not of Lymphoid-Related CD8α+ Dendritic Cells

1998 • 443 citations

Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation

2003 • 441 citations

Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut

2003 • 435 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

In Vivo Expression of Toll-Like Receptor 2 and 4 by Renal Epithelial Cells: IFN-γ and TNF-α Mediated Up-Regulation During Inflammation

2002 • 431 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

Current insights into the regulation of programmed cell death by NF-κB

2006 • 399 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

Dendritic Cell Development and Survival Require Distinct NF-κB Subunits

2002 • 395 citations

TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway

2003 • 385 citations

CARMA1, BCL-10 and MALT1 in lymphocyte development and activation

2004 • 378 citations

Differential Requirement for Malt1 in T and B Cell Antigen Receptor Signaling

2003 • 375 citations

Regulation of NF-κB-Dependent Lymphocyte Activation and Development by Paracaspase

2003 • 366 citations

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

2004 • 358 citations

CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

2002 • 338 citations

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

1999 • 336 citations

Phosphorylation of the CARMA1 Linker Controls NF-κB Activation

2005 • 333 citations

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosis in Vitro

1999 • 329 citations

CARD11 and CARD14 Are Novel Caspase Recruitment Domain (CARD)/Membrane-associated Guanylate Kinase (MAGUK) Family Members that Interact with BCL10 and Activate NF-κB

2001 • 328 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

The MAGUK Family Protein CARD11 Is Essential for Lymphocyte Activation

2003 • 326 citations

Activation of the NF-κB Pathway by Inflammatory Stimuli in Human Neutrophils

1997 • 321 citations

Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

2003 • 320 citations

PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling

2002 • 319 citations

Toll-Like Receptor 4 Mediates Intracellular Signaling Without TNF-α Release in Response to Cryptococcus neoformans Polysaccharide Capsule

2001 • 308 citations

Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death

2001 • 305 citations

B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching.

1996 • 304 citations

NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

1997 • 296 citations

Toll-like Receptor (TLR) Signaling in Response toAspergillus fumigatus

2002 • 296 citations

Phosphorylation of CARMA1 Plays a Critical Role in T Cell Receptor-Mediated NF-κB Activation

2005 • 282 citations

A FADD-dependent innate immune mechanism in mammalian cells

2004 • 281 citations

NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

2000 • 280 citations

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration

2000 • 279 citations

Evidence for an Accessory Protein Function for Toll-Like Receptor 1 in Anti-Bacterial Responses

2000 • 273 citations

Control of lymphocyte development by nuclear factor-κB

2005 • 271 citations

Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment

2001 • 260 citations

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

2000 • 259 citations

Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

2006 • 259 citations

Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

2003 • 258 citations

Requirement for CARMA1 in Antigen Receptor-Induced NF-κB Activation and Lymphocyte Proliferation

2003 • 253 citations

B Lymphocytes Differentially Use the Rel and Nuclear Factor κB1 (NF-κB1) Transcription Factors to Regulate Cell Cycle Progression and Apoptosis in Quiescent and Mitogen-activated Cells

1998 • 250 citations

Positive and Negative Regulation of NF-κB by COX-2

2001 • 250 citations

PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation

2005 • 249 citations

MEK kinase 1 gene disruption alters cell migration and c-Jun NH ₂ -terminal kinase regulation but does not cause a measurable defect in NF-κB activation

2000 • 240 citations

Protein Kinase C β Controls Nuclear Factor κB Activation in B Cells Through Selective Regulation of the IκB Kinase α

2002 • 239 citations

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

2000 • 226 citations

Inhibition of Nuclear Factor κB Activation Attenuates Apoptosis Resistance in Lymphoid Cells

1998 • 225 citations

Inhibition of Neutrophil Apoptosis by TLR Agonists in Whole Blood: Involvement of the Phosphoinositide 3-Kinase/Akt and NF-κB Signaling Pathways, Leading to Increased Levels of Mcl-1, A1, and Phosphorylated Bad

2005 • 222 citations

Nuclear factor ?B/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1?-stimulated synovial fibroblasts

1998 • 222 citations

Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines

2001 • 221 citations

RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF

2002 • 213 citations

IKKβ Is Essential for Protecting T Cells from TNFα-Induced Apoptosis

2001 • 208 citations

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

2004 • 207 citations

An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis

1999 • 207 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

Carma1, a CARD‐containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF‐κB activation¹

2001 • 195 citations

Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells

1997 • 193 citations

Tollip Regulates Proinflammatory Responses to Interleukin-1 and Lipopolysaccharide

2006 • 189 citations

BCL-3 and NF-κB p50 Attenuate Lipopolysaccharide-induced Inflammatory Responses in Macrophages

2004 • 188 citations

Iκb Kinase α Is Essential for Mature B Cell Development and Function

2001 • 186 citations

Targeted disruption ofTraf5gene causes defects in CD40- and CD27-mediated lymphocyte activation

1999 • 185 citations

IκB Kinase Signaling Is Essential for Maintenance of Mature B Cells

2002 • 179 citations

IDENTIFICATION AND CHARACTERIZATION OF SIGIRR, A MOLECULE REPRESENTING A NOVEL SUBTYPE OF THE IL-1R SUPERFAMILY

1999 • 179 citations

IKKβ Is Required for Peripheral B Cell Survival and Proliferation

2003 • 177 citations

The role of porins in neisserial pathogenesis and immunity

2003 • 170 citations

A Role for Fas in Negative Selection of Thymocytes In Vivo

1998 • 167 citations

Immunological defects in mice with a targeted disruption in Bcl-3.

1997 • 164 citations

TGF-α Regulates TLR Expression and Function on Epidermal Keratinocytes

2005 • 155 citations

The role of Toll-like receptor 2 in microbial disease and immunity

2003 • 154 citations

Role of nuclear factor‐κB in the immune system and bone

2005 • 152 citations

Identification of a Sequence in Human Toll-like Receptor 5 Required for the Binding of Gram-negative Flagellin

2003 • 151 citations

Differential Regulation of Lipopolysaccharide-Induced Monocyte Matrix Metalloproteinase (MMP)-1 and MMP-9 by p38 and Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinases

2003 • 149 citations

The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF

2001 • 149 citations

The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects

1999 • 144 citations

IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508

2005 • 138 citations

The Physical Association of Protein Kinase Cθ with a Lipid Raft-Associated Inhibitor of κB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-κB Cascade by TCR and CD28

2000 • 136 citations

Enhanced NF-κB activation and cellular function in macrophages lacking IκB kinase 1 (IKK1)

2005 • 124 citations

Interactions of Toll-like receptors with fungi

2004 • 122 citations

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

2004 • 120 citations

c-Rel Is Required for Chromatin Remodeling Across the IL-2 Gene Promoter

2003 • 120 citations

B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching.

1996 • 111 citations

Type I Interferon Induction Pathway, but Not Released Interferon, Participates in the Maturation of Dendritic Cells Induced by Negative‐Strand RNA Viruses

2003 • 109 citations

Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs

2002 • 105 citations

Role of the Toll/interleukin‐1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasites

2004 • 105 citations

Regulation of cytokine gene expression in T helper cell subsets.

1994 • 102 citations

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

2003 • 99 citations

IL‐1β‐dependent activation of NF‐κB mediates PGE₂ release via the expression of cyclooxygenase‐2 and microsomal prostaglandin E synthase

2003 • 99 citations

Th2 Cytokines Down-Regulate TLR Expression and Function in Human Intestinal Epithelial Cells

2006 • 98 citations

Constitutive Expression of Bcl-3 in Thymocytes Increases the DNA Binding of NF-κB1 (p50) Homodimers In Vivo

1996 • 98 citations

The splenic marginal zone is absent in alymphoplastic aly mutant mice

1996 • 94 citations

Rip2 Participates in Bcl10 Signaling and T-cell Receptor-mediated NF-κB Activation

2004 • 92 citations

Bcl-3 and NFκB p50-p50 Homodimers Act as Transcriptional Repressors in Tolerant CD4+ T Cells

2004 • 88 citations

Balance between NF-κB and JNK/AP-1 activity controls dendritic cell life and death

2005 • 87 citations

Essential Role of IκB Kinase α in Thymic Organogenesis Required for the Establishment of Self-Tolerance

2006 • 86 citations

The Survival of Antigen-Stimulated T Cells Requires NFκB-Mediated Inhibition of p73 Expression

2003 • 86 citations

B cells genetically deficient in the c-Rel transactivation domain have selective defects in germline CH transcription and Ig class switching.

1997 • 85 citations

Opposing Roles for RelB and Bcl-3 in Regulation of T-Box Expressed in T Cells, GATA-3, and Th Effector Differentiation

2005 • 84 citations

A Novel Synthetic Acyclic Lipid A-like Agonist Activates Cells via the Lipopolysaccharide/Toll-like Receptor 4 Signaling Pathway

2001 • 84 citations

An Essential Role for NF-κB in Human CD34+ Bone Marrow Cell Survival

1999 • 84 citations

Nuclear factor-kappa B pathways in Drosophila

2006 • 77 citations

Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo

2003 • 76 citations

Induction of the NF-κB Cascade by Recruitment of the Scaffold Molecule NEMO to the T Cell Receptor

2003 • 71 citations

c-Rel Is Required for the Protection of B Cells from Antigen Receptor-Mediated, But Not Fas-Mediated, Apoptosis

2001 • 71 citations

c-Rel-Dependent Priming of Naive T Cells by Inflammatory Cytokines

2005 • 68 citations

Multiple Hemopoietic Defects and Lymphoid Hyperplasia in Mice Lacking the Transcriptional Activation Domain of the c-Rel Protein

1998 • 66 citations

Abnormal organogenesis of Peyer's patches in mice deficient for NF-κB1, NF-κB2, and Bcl-3

2002 • 66 citations

A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing

2006 • 64 citations

Inhibition of Phorbol Ester-Induced Cellular Adhesion by Competitive Binding of NF-κB In Vivo

1993 • 61 citations

Opposing roles of NF-κB family members in the regulation of NK cell proliferation and production of IFN-γ

2006 • 56 citations

Treatment advances in adult Burkitt lymphoma and leukemia

2004 • 55 citations

NF-κB inducible genes BCL-X and cyclin E promote immature B-cell proliferation and survival

2004 • 51 citations

NF-κB/Rel Participation in the Lymphokine-Dependent Proliferation of T Lymphoid Cells

2001 • 50 citations

IκBα/IκBε deficiency reveals that a critical NF-κB dosage is required for lymphocyte survival

2003 • 45 citations

Role of membrane microdomain rafts in TNFR-mediated signal transduction

2003 • 45 citations

The p65 Subunit of NF-κB Is Redundant with p50 During B Cell Proliferative Responses, and Is Required for Germline CH Transcription and Class Switching to IgG3

1999 • 42 citations

Activation of NF-κB promotes the transition of large, CD43+ pre-B cells to small, CD43− pre-B cells

2005 • 42 citations

IκB Kinase 2 Deficiency in T Cells Leads to Defects in Priming, B Cell Help, Germinal Center Reactions, and Homeostatic Expansion

2004 • 42 citations

Transcription Factor Activation during Signal-induced Apoptosis of Immature CD4+CD8+ Thymocytes

1997 • 41 citations

Inefficient ZAP-70 Phosphorylation and Decreased Thymic Selection In Vivo Result from Inhibition of NF-κB/Rel

2001 • 37 citations

Regulation of Developing B Cell Survival by RelA-Containing NF-κB Complexes

2003 • 35 citations

Co-operative induction of pro-inflammatory signaling by Toll-like receptors

2000 • 33 citations

Transcriptional Regulation in Neutrophils: Teaching Old Cells New Tricks

2004 • 33 citations

Inhibition of Nuclear Factor κB Activation Attenuates Apoptosis Resistance in Lymphoid Cells

1998 • 31 citations

Combined deficiency in IκBα and IκBϵ reveals a critical window of NF-κB activity in natural killer cell differentiation

2004 • 30 citations

Overexpression of p65 and c-Jun Substitutes for B7-1 Costimulation by Targeting the CD28RE Within the IL-2 Promoter

1998 • 23 citations