SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

2002 • 1,228 citations

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling

2002 • 1,224 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

1997 • 1,159 citations

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 • 1,104 citations

IRAK: A Kinase Associated with the Interleukin-1 Receptor

1996 • 894 citations

The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense

2003 • 696 citations

IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase

2002 • 676 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

MyD88, an Adapter Protein Involved in Interleukin-1 Signaling

1998 • 634 citations

Interleukin-1

1997 • 566 citations

Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4

2003 • 494 citations

T1/St2-Deficient Mice Demonstrate the Importance of T1/St2 in Developing Primary T Helper Cell Type 2 Responses

2000 • 476 citations

The role of IL-18 in innate immunity

2000 • 376 citations

Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR

2003 • 300 citations

Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol

2002 • 279 citations

Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus

1995 • 277 citations

Regulation of Interleukin-1- and Lipopolysaccharide-Induced NF-κB Activation by Alternative Splicing of MyD88

2002 • 275 citations

Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway

2001 • 195 citations

IDENTIFICATION AND CHARACTERIZATION OF SIGIRR, A MOLECULE REPRESENTING A NOVEL SUBTYPE OF THE IL-1R SUPERFAMILY

1999 • 179 citations

Inflammatory bowel disease: new insights into pathogenesis and treatment

2002 • 172 citations

Pellino 1 Is Required for Interleukin-1 (IL-1)-mediated Signaling through Its Interaction with the IL-1 Receptor-associated Kinase 4 (IRAK4)-IRAK-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Complex

2003 • 169 citations

The pathogenesis of rheumatoid arthritis: pivotal cytokines involved in bone degradation and inflammation.

2002 • 144 citations

Pathophysiologic basis of sepsis: Considerations for future strategies of intervention

2000 • 108 citations

The Membrane Form of the Type II IL-1 Receptor Accounts for Inhibitory Function

2000 • 75 citations

Bacterial Lipopolysaccharide Causes Rapid Shedding, Followed by Inhibition of mRNA Expression, of the IL-1 Type II Receptor, with Concomitant Up-Regulation of the Type I Receptor and Induction of Incompletely Spliced Transcripts

1999 • 63 citations

DIVERGENT EFFECTS OF LPS ON EXPRESSION OF IL-1 RECEPTOR FAMILY MEMBERS IN MONONUCLEAR PHAGOCYTES IN VITRO AND IN VIVO

1998 • 43 citations