Organogenesis of lymphoid tissues

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Prox1 Function Is Required for the Development of the Murine Lymphatic System

1999 • 1,525 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

RANK is essential for osteoclast and lymph node development

1999 • 1,417 citations

A chemokine-driven positive feedback loop organizes lymphoid follicles

2000 • 1,220 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

1996 • 1,125 citations

Induction of Pancreatic Differentiation by Signals from Blood Vessels

2001 • 1,052 citations

Chemokines and Cell Migration in Secondary Lymphoid Organs

1999 • 1,046 citations

Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization

1999 • 1,030 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

Liver Organogenesis Promoted by Endothelial Cells Prior to Vascular Function

2001 • 857 citations

Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

1999 • 841 citations

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1

1998 • 810 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development

2000 • 714 citations

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

1998 • 710 citations

Lymphoid Neogenesis in Rheumatoid Synovitis

2001 • 656 citations

Developing Lymph Nodes Collect CD4 + CD3 − LTβ + Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells

1997 • 654 citations

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

1999 • 639 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice

1997 • 590 citations

Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in theplt/pltmouse

2000 • 580 citations

Lymphotoxin α/β and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

1999 • 552 citations

On the origin of the lymphatic system from the veins and the development of the lymph hearts and thoracic duct in the pig

1902 • 542 citations

Differing Activities of Homeostatic Chemokines CCL19, CCL21, and CXCL12 in Lymphocyte and Dendritic Cell Recruitment and Lymphoid Neogenesis

2002 • 530 citations

Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches

2002 • 502 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

BLC Expression in Pancreatic Islets Causes B Cell Recruitment and Lymphotoxin-Dependent Lymphoid Neogenesis

2000 • 450 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.

1995 • 436 citations

Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

2001 • 407 citations

Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs.

1996 • 392 citations

Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice

1997 • 365 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

Distinct roles for lymphotoxin‐α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue

1997 • 318 citations

Mature Follicular Dendritic Cell Networks Depend on Expression of Lymphotoxin β Receptor by Radioresistant Stromal Cells and of Lymphotoxin β and Tumor Necrosis Factor by B Cells

1999 • 314 citations

Retinoid-related orphan receptor γ (RORγ) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis

2000 • 308 citations

B Lymphocytes Induce the Formation of Follicular Dendritic Cell Clusters in a Lymphotoxin α–dependent Fashion

1998 • 296 citations

Thyroid Autoimmune Disease

2001 • 295 citations

Lymph Node Genesis Is Induced by Signaling through the Lymphotoxin β Receptor

1998 • 294 citations

The lymphatic system in human embryos, with a consideration of the morphology of the system as a whole

1909 • 292 citations

IL-7 receptor α+ CD3– cells in the embryonic intestine induces the organizing center of Peyer's patches

1999 • 289 citations

Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sj�gren's syndrome

2001 • 272 citations

Regulation of Peripheral Lymph Node Genesis by the Tumor Necrosis Factor Family Member Trance

2000 • 262 citations

Targeted Disruption of LIGHT Causes Defects in Costimulatory T Cell Activation and Reveals Cooperation with Lymphotoxin β in Mesenteric Lymph Node Genesis

2002 • 255 citations

The Fetal Liver Counterpart of Adult Common Lymphoid Progenitors Gives Rise to All Lymphoid Lineages, CD45+CD4+CD3− Cells, As Well As Macrophages

2001 • 240 citations

Different Cytokines Induce Surface Lymphotoxin-αβ on IL-7 Receptor-α Cells that Differentially Engender Lymph Nodes and Peyer's Patches

2002 • 240 citations

Lymphoid neogenesis:de novoformation of lymphoid tissue in chronic inflammation through expression of homing chemokines

2001 • 236 citations

The Sequential Role of Lymphotoxin and B Cells in the Development of Splenic Follicles

1998 • 232 citations

Molecular Basis for Hematopoietic/Mesenchymal Interaction during Initiation of Peyer's Patch Organogenesis

2001 • 231 citations

Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines

2001 • 221 citations

The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes

1999 • 217 citations

RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF

2002 • 213 citations

Initiation of NALT Organogenesis Is Independent of the IL-7R, LTβR, and NIK Signaling Pathways but Requires the Id2 Gene and CD3−CD4+CD45+ Cells

2002 • 212 citations

Three distinctive steps in Peyer's patch formation of murine embryo

1997 • 205 citations

Peyer’s patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

1997 • 205 citations

Ectopic Expression of the Murine Chemokines CCL21a and CCL21b Induces the Formation of Lymph Node-Like Structures in Pancreas, But Not Skin, of Transgenic Mice

2002 • 201 citations

Distinct Role of Surface Lymphotoxin Expressed by B Cells in the Organization of Secondary Lymphoid Tissues

2002 • 201 citations

Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I

2001 • 200 citations

CD4+CD3− Cells Induce Peyer's Patch Development

2002 • 194 citations

Cutting Edge: Ectopic Expression of the Chemokine TCA4/SLC Is Sufficient to Trigger Lymphoid Neogenesis

2000 • 187 citations

Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor.

1996 • 181 citations

Expression of the B Cell‐Attracting Chemokine CXCL13 in the Target Organ and Autoantibody Production in Ectopic Lymphoid Tissue in the Chronic Inflammatory Disease Sjögren's Syndrome

2002 • 165 citations

Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage

1998 • 161 citations

Enterocyte Expression of Interleukin 7 Induces Development of γδ T Cells and Peyer's Patches

2000 • 143 citations

Expression of α4β7 Integrin Defines a Distinct Pathway of Lymphoid Progenitors Committed to T Cells, Fetal Intestinal Lymphotoxin Producer, NK, and Dendritic Cells

2001 • 138 citations

Genetic defect in T lymphocyte‐specific homing into peripheral lymph nodes

1997 • 138 citations

On the development of the superficial lymphatics in the skin of the pig

1904 • 122 citations

Cutting Edge: Organogenesis of Nasal-Associated Lymphoid Tissue (NALT) Occurs Independently of Lymphotoxin-α (LTα) and Retinoic Acid Receptor-Related Orphan Receptor-γ, but the Organization of NALT Is LTα Dependent

2002 • 121 citations

Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ development.

1998 • 115 citations

Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs

2002 • 105 citations

Lymphotoxin α3 Induces Chemokines and Adhesion Molecules: Insight into the Role of LTα in Inflammation and Lymphoid Organ Development

1998 • 99 citations

Compartmentalization of Peyer’s Patch Anlagen Before Lymphocyte Entry

2001 • 97 citations

Visualization of Lymphotoxin-β and Lymphotoxin-β Receptor Expression in Mouse Embryos

2002 • 84 citations

NF-κB-Inducing Kinase Is Dispensable for Activation of NF-κB in Inflammatory Settings but Essential for Lymphotoxin β Receptor Activation of NF-κB in Primary Human Fibroblasts

2001 • 84 citations

Differential induction of adhesion molecule and chemokine expression by LTalpha3 and LTalphabeta in inflammation elucidates potential mechanisms of mesenteric and peripheral lymph node development.

1999 • 79 citations

TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes.

1999 • 77 citations

A Role for Tumor Necrosis Factor Receptor Type 1 in Gut-associated Lymphoid Tissue Development: Genetic Evidence of Synergism with Lymphotoxin β

1998 • 74 citations

Differential Induction of Adhesion Molecule and Chemokine Expression by LTα3 and LTαβ in Inflammation Elucidates Potential Mechanisms of Mesenteric and Peripheral Lymph Node Development

1999 • 68 citations

Abnormal organogenesis of Peyer's patches in mice deficient for NF-κB1, NF-κB2, and Bcl-3

2002 • 66 citations

TNF and Lymphotoxin β Cooperate in the Maintenance of Secondary Lymphoid Tissue Microarchitecture But Not in the Development of Lymph Nodes

1999 • 65 citations

Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis.

1999 • 61 citations

The histogenesis of lymph nodes in rat and rabbit

1978 • 55 citations

Involvement of Distinct Cellular Compartments in the Abnormal Lymphoid Organogenesis in Lymphotoxin-α-Deficient Mice and Alymphoplasia (aly) Mice Defined by the Chimeric Analysis

1999 • 54 citations

Ontogeny of human fetal lymph nodes

1975 • 43 citations

Symposium on the development and structure of the lymphatic system. III. Further evidence on the origin of the lymphatic endothelium from the endothelium of the blood vascular system

1908 • 27 citations