Induction of the NF-κB Cascade by Recruitment of the Scaffold Molecule NEMO to the T Cell Receptor

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

NF-κB regulation in the immune system

2002 • 3,804 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

The Immunological Synapse

2001 • 987 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

2000 • 685 citations

CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

2002 • 338 citations

Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation

2001 • 301 citations

A requirement for CARMA1 in TCR-induced NF-κB activation

2002 • 288 citations

Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line

1998 • 269 citations

Fatty Acylation of Proteins

1988 • 253 citations

The Membrane-Microfilament Linker Ezrin Is Involved in the Formation of the Immunological Synapse and in T Cell Activation

2001 • 189 citations

Activation of the IκB Kinases by RIP via IKKγ/NEMO-mediated Oligomerization

2000 • 171 citations

Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases

2002 • 147 citations

The Physical Association of Protein Kinase Cθ with a Lipid Raft-Associated Inhibitor of κB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-κB Cascade by TCR and CD28

2000 • 136 citations

Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases

2002 • 130 citations

Direct Association and Nuclear Import of the Hepatitis B Virus X Protein with the NF-κB Inhibitor IκBα

1999 • 130 citations

Triggering the TCR Complex Causes the Downregulation of Nonengaged Receptors by a Signal Transduction-Dependent Mechanism

2000 • 122 citations

Phorbol Esters and Cytokines Regulate the Expression of theNEMO-related Protein, a Molecule Involved in a NF-κB-independent Pathway

2000 • 112 citations

Somatic mutagenesis studies of NF-κB signaling in human T cells: evidence for an essential role of IKKγ in NF-κB activation by T-cell costimulatory signals and HTLV-I Tax protein

2000 • 111 citations

Regulation of IκBβ Degradation

1997 • 109 citations

ZAP-70 and SLP-76 Regulate Protein Kinase C-θ and NF-κB Activation in Response to Engagement of CD3 and CD28

2001 • 74 citations

Mutation of Tyrosines 492/493 in the Kinase Domain of ZAP-70 Affects Multiple T-cell Receptor Signaling Pathways

1996 • 72 citations

Peptide antigen or superantigen-induced down-regulation of TCRs involves both stimulated and unstimulated receptors.

1997 • 62 citations

Anti-peptide Antibodies Detect Conformational Changes of the Inter-SH2 Domain of ZAP-70 Due to Binding to the ζ Chain and to Intramolecular Interactions

1998 • 22 citations

Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor

2002 • 20 citations