TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

NF-κB: Ten Years After

1996 • 3,008 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

2001 • 2,027 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

2000 • 1,801 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

1999 • 1,163 citations

How NF-κB is activated: the role of the IκB kinase (IKK) complex

1999 • 1,133 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

2001 • 1,055 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

1999 • 827 citations

RNA interference—2001

2001 • 698 citations

Limb and Skin Abnormalities in Mice Lacking IKKα

1999 • 609 citations

TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway

2000 • 589 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

1999 • 581 citations

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1999 • 475 citations

The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.

1992 • 446 citations

Double-Stranded RNA as a Template for Gene Silencing

2000 • 421 citations

TAK1 Mediates the Ceramide Signaling to Stress-activated Protein Kinase/c-Jun N-terminal Kinase

1997 • 336 citations

IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex

1999 • 333 citations

Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex

1999 • 324 citations

Receptor Activator of NF-κB Ligand (RANKL) Activates TAK1 Mitogen-Activated Protein Kinase Kinase Kinase through a Signaling Complex Containing RANK, TAB2, and TRAF6

2002 • 277 citations

Domains in the SPT5 Protein That Modulate Its Transcriptional Regulatory Properties

2000 • 223 citations

Functional Interactions of Transforming Growth Factor β-activated Kinase 1 with IκB Kinases to Stimulate NF-κB Activation

1999 • 218 citations

Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation

2000 • 202 citations

Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway

2001 • 195 citations

Iκb Kinase α Is Essential for Mature B Cell Development and Function

2001 • 186 citations

Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis

1999 • 180 citations

The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF

2001 • 149 citations

The Conserved Pre-mRNA Splicing Factor U2AF from Drosophila : Requirement for Viability

1993 • 89 citations

IKKγ/NEMO Facilitates the Recruitment of the IκB Proteins into the IκB Kinase Complex

2001 • 53 citations

Analysis of Domains in the IKKα and IKKβ Proteins That Regulate Their Kinase Activity

2000 • 48 citations