NF-κB/Rel Participation in the Lymphokine-Dependent Proliferation of T Lymphoid Cells

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

1999 • 1,532 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

1992 • 843 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

The complete nucleotide sequence of mouse 28S rRNA gene. Implications for the process of size increase of the large subunit rRNA In higher eukaryotes

1984 • 619 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?

1997 • 381 citations

Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

1994 • 359 citations

The interleukin-2 receptor.

1991 • 354 citations

Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation

1994 • 340 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis

1995 • 325 citations

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

1994 • 306 citations

B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching.

1996 • 304 citations

NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

1997 • 296 citations

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

1997 • 293 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.

1990 • 263 citations

Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-κB

1997 • 259 citations

B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes.

1987 • 251 citations

The Interleukin 2 Receptor

1989 • 244 citations

Interleukin 2 and its receptors: recent advances and new immunological functions

1996 • 241 citations

The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat5

2000 • 234 citations

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.

1996 • 202 citations

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.

1995 • 201 citations

Functionally Distinct NF-κB Binding Sites in the Immunoglobulin κ and IL-2 Receptor α Chain Genes

1989 • 194 citations

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

1993 • 173 citations

Stat5 Activation Is Uniquely Associated with Cytokine Signaling in Peripheral T Cells

1999 • 171 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division.

1995 • 152 citations

Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression.

1988 • 145 citations

B-cell stimulatory factor 1 and not interleukin 2 is the autocrine growth factor for some helper T lymphocytes.

1987 • 141 citations

Stat Proteins Control Lymphocyte Proliferation by Regulating p27^Kip1 Expression

1998 • 133 citations

Signaling via IL-2 and IL-4 in JAK3-Deficient Severe Combined Immunodeficiency Lymphocytes: JAK3-Dependent and Independent Pathways

1996 • 129 citations

IL-4 induces Fas resistance in B cells.

1996 • 115 citations

T Cell Receptor–Induced Calcineurin Activation Regulates T Helper Type 2 Cell Development by Modifying the Interleukin 4 Receptor Signaling Complex

2000 • 111 citations

Impaired Interleukin 4 Signaling in T Helper Type 1 Cells

1998 • 94 citations

Repression of IL-4-induced gene expression by IFN-gamma requires Stat1 activation.

1999 • 92 citations

Regulation of Cell Growth by IL-2: Role of STAT5 in Protection from Apoptosis But Not in Cell Cycle Progression

1998 • 90 citations

Interleukin 4 signals through two related pathways.

1995 • 90 citations

Peripheral Expression of Jak3 Is Required to Maintain T Lymphocyte Function

1997 • 89 citations

The Interleukin-4 Receptor Activates STAT5 by a Mechanism That Relies upon Common γ-Chain

1998 • 83 citations

B cell stimulatory factor 1 (BSF-1) prepares resting B cells to enter S phase in response to anti-IgM and lipopolysaccharide.

1986 • 81 citations

IL-4-dependent up-regulation of IL-4 receptor expression in murine T and B cells.

1991 • 73 citations

Repression of IL-4-Induced Gene Expression by IFN-γ Requires Stat1 Activation

1999 • 71 citations

Insulin Receptor Substrate-2 Is the Major 170-kDa Protein Phosphorylated on Tyrosine in Response to Cytokines in Murine Lymphohemopoietic Cells

1997 • 68 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 64 citations

Jak1 Expression Is Required for Mediating Interleukin-4-induced Tyrosine Phosphorylation of Insulin Receptor Substrate and Stat6 Signaling Molecules

1997 • 60 citations

Transient Inhibition of Interleukin 4 Signaling by T Cell Receptor Ligation

2000 • 59 citations

Requirement for Jak3 in Mature T Cells: Its Role in Regulation of T Cell Homeostasis

1998 • 40 citations

Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation

1999 • 40 citations

Differences in the interleukin‐2 (IL‐2) receptor system in human and mouse: α chain is required for formation of the functional mouse IL‐2 receptor

1995 • 37 citations

IL-4-DEPENDENT INDUCTION OF BCL-2 AND BCL-XLIN ACTIVATED T LYMPHOCYTES THROUGH A STAT6- AND PI 3-KINASE-INDEPENDENT PATHWAY

2000 • 34 citations

The IL-4-induced tyrosine phosphorylation of the insulin receptor substrate is dependent on JAK1 expression in human fibrosarcoma cells.

1997 • 32 citations

Regulation of gene expression, growth, and cell survival by IL-4: Contribution of multiple signaling pathways

1998 • 29 citations

Control of the IL-2 responsiveness of B lymphocytes by IL-2 and IL-4.

1995 • 28 citations

Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkappaBalpha degradation.

1999 • 25 citations

IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes.

1992 • 25 citations

Costimulation Reverses the Defect in IL-2 But Not Effector Cytokine Production by T Cells with Impaired IκBα Degradation

1999 • 24 citations

Signal transduction through the IL‐4 and insulin receptor families

1995 • 22 citations

Independent pathways for de-repression of the mouse Ig heavy chain germ-line ε promoter: an IL-4 NAF/NF-IL-4 site as a context-dependent negative element

1996 • 21 citations

Induction of competence to respond to IL-4 by CD4+ T helper type 1 cells requires costimulation.

1992 • 18 citations

IL-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor beta-chain transgenic mice.

1994 • 17 citations

In Vivo Function of an Interleukin 2 Receptor β Chain (IL-2Rβ)/IL-4Rα Cytokine Receptor Chimera Potentiates Allergic Airway Disease

1998 • 14 citations

Expression of murine IL-2 receptor beta-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative response in human IL-2 receptor alpha-chain transgenic mice.

1990 • 12 citations