Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

NF-κB at the crossroads of life and death

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Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

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Inducible Gene Targeting in Mice

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Clonal selection and learning in the antibody system

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Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells

1995 • 1,269 citations

B Cell Development Pathways

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In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

2002 • 909 citations

B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

1999 • 843 citations

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

2001 • 551 citations

Resolution of Three Nonproliferative Immature Splenic B Cell Subsets Reveals Multiple Selection Points During Peripheral B Cell Maturation

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B cell antigen receptor signaling 101

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Expression and function of the interleukin 7 receptor in murine lymphocytes.

1993 • 496 citations

Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ.

1988 • 487 citations

BAFF/BLyS Receptor 3 Binds the B Cell Survival Factor BAFF Ligand through a Discrete Surface Loop and Promotes Processing of NF-κB2

2002 • 468 citations

INITIATION AND PROCESSING OF SIGNALS FROM THE B CELL ANTIGEN RECEPTOR

1997 • 440 citations

Most peripheral B cells in mice are ligand selected.

1991 • 424 citations

Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells.

1993 • 413 citations

Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

2001 • 375 citations

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

1993 • 345 citations

Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice

1999 • 335 citations

Homeostasis of Peripheral B Cells in the Absence of B Cell Influx from the Bone Marrow

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Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

1996 • 290 citations

B Cell Antigen Receptor Signaling: Roles in Cell Development and Disease

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Normal B Cell Homeostasis Requires B Cell Activation Factor Production by Radiation-resistant Cells

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IFN‐α/β enhances BCR‐dependent B cell responses

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The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow.

1990 • 239 citations

Mutations in Igα (CD79a) result in a complete block in B-cell development

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Receptor Selection in B and T Lymphocytes

2000 • 226 citations

How αβ T cells deal with induced TCRα ablation

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How Much TCR Does a T Cell Need?

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The role of CD95 in the regulation of peripheral T‐cell apoptosis

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Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor.

1994 • 190 citations

Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells

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IκB Kinase Signaling Is Essential for Maintenance of Mature B Cells

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Laboratory Protocols for Conditional Gene Targeting

1997 • 176 citations

Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice.

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A B-cell receptor-specific selection step governs immature to mature B cell differentiation

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Cutting Edge: B Cell Receptor Signals Regulate BLyS Receptor Levels in Mature B Cells and Their Immediate Progenitors

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NF-κB1 p50 Is Required for BLyS Attenuation of Apoptosis but Dispensable for Processing of NF-κB2 p100 to p52 in Quiescent Mature B Cells

2003 • 130 citations

Antigen-dependent B-cell development

2002 • 130 citations

Transducing signals from antigen receptors to nuclear factor κB

2003 • 121 citations

Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail

2001 • 119 citations

B Cell Progenitors Are Arrested in Maturation but Have Intact VDJ Recombination in the Absence of Ig-α and Ig-β

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B Cell Development Is Arrested at the Immature B Cell Stage in Mice Carrying a Mutation in the Cytoplasmic Domain of Immunoglobulin β

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Regulation of B cell fates by BCR signaling components

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A simple assay to determine the functionality of Cre or FLP recombination targets in genomic manipulation constructs

1996 • 104 citations

Basal B‐cell receptor signaling in B lymphocytes: mechanisms of regulation and role in positive selection, differentiation, and peripheral survival

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An unsolved problem of the clonal selection theory and the model of an oligomeric B‐cell antigen receptor

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Novel Igα (CD79a) gene mutation in a Turkish patient with B cell‐deficient agammaglobulinemia

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Ig-α Cytoplasmic Truncation Renders Immature B Cells More Sensitive to Antigen Contact

1999 • 62 citations

The role of Rel/NF-κB transcription factors in B lymphocyte survival

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Deletion of immunoglobulin β in developing B cells leads to cell death

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A Negative Regulatory Role for Ig-α during B Cell Development

1999 • 46 citations

Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion.

1991 • 37 citations