Inhibition of Neutrophil Apoptosis by TLR Agonists in Whole Blood: Involvement of the Phosphoinositide 3-Kinase/Akt and NF-κB Signaling Pathways, Leading to Increased Levels of Mcl-1, A1, and Phosphorylated Bad

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

A blast from the past: clearance of apoptotic cells regulates immune responses

2002 • 1,558 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

2008 • 1,268 citations

Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

2002 • 1,214 citations

Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products

1992 • 1,103 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

1995 • 923 citations

Toll-like receptors stimulate human neutrophil function

2003 • 906 citations

Flow Cytometric Analysis of Respiratory Burst Activity in Phagocytes With Hydroethidine and 2′,7′-Dichlorofluorescin

1990 • 869 citations

Oxidants from phagocytes: agents of defense and destruction

1984 • 803 citations

Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

2003 • 789 citations

Tlr4: central component of the sole mammalian LPS sensor

2000 • 764 citations

IκB kinases: key regulators of the NF-κB pathway

2004 • 618 citations

Phagocytosis and innate immunity

2002 • 579 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

HSP27 inhibits cytochrome c‐dependent activation of procaspase‐9

1999 • 496 citations

Molecular control of neutrophil apoptosis

2001 • 484 citations

Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

2001 • 477 citations

Hsp27 as a Negative Regulator of Cytochrome c Release

2002 • 429 citations

Toll-Like Receptor (TLR)2 and TLR4 in Human Peripheral Blood Granulocytes: A Critical Role for Monocytes in Leukocyte Lipopolysaccharide Responses

2002 • 385 citations

Heat Shock Protein 27 Controls Apoptosis by Regulating Akt Activation

2003 • 366 citations

Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival

1998 • 349 citations

Selective Roles for Toll-Like Receptor (TLR)2 and TLR4 in the Regulation of Neutrophil Activation and Life Span

2003 • 340 citations

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosis in Vitro

1999 • 329 citations

Sesquiterpene Lactones Specifically Inhibit Activation of NF-κB by Preventing the Degradation of IκB-α and IκB-β

1998 • 325 citations

Expression and Function of Toll-Like Receptors in Eosinophils: Activation by Toll-Like Receptor 7 Ligand

2003 • 299 citations

Regulation of Neutrophil Apoptosis by Tumor Necrosis Factor-α: Requirement for TNFR55 and TNFR75 for Induction of Apoptosis In Vitro

1997 • 296 citations

Activation of protein kinase B (Akt/RAC‐protein kinase) by cellular stress and its association with heat shock protein Hsp27

1997 • 270 citations

Granulocyte-Macrophage Colony-Stimulating Factor Delays Neutrophil Constitutive Apoptosis Through Phosphoinositide 3-Kinase and Extracellular Signal-Regulated Kinase Pathways

2000 • 262 citations

Granulocyte apoptosis and the control of inflammation

1994 • 232 citations

Granulocyte Macrophage Colony-stimulating Factor Signaling and Proteasome Inhibition Delay Neutrophil Apoptosis by Increasing the Stability of Mcl-1

2004 • 223 citations

p38-MAPK Signals Survival by Phosphorylation of Caspase-8 and Caspase-3 in Human Neutrophils

2004 • 205 citations

Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9

2004 • 189 citations

Involvement of Phosphoinositide 3-Kinases in Neutrophil Activation and the Development of Acute Lung Injury

2001 • 188 citations

Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils

2001 • 180 citations

Interference of BAD (Bcl-xL/Bcl-2-Associated Death Promoter)-Induced Apoptosis in Mammalian Cells by 14–3-3 Isoforms and P11

1997 • 176 citations

Membrane Potential Estimation by Flow Cytometry

2000 • 167 citations

Oncostatin M Production and Regulation by Human Polymorphonuclear Neutrophils

1999 • 162 citations

Phosphoinositide 3 Kinase Mediates Toll-Like Receptor 4-Induced Activation of NF-κB in Endothelial Cells

2003 • 139 citations

Phosphoinositide 3-Kinase and Akt Occupy Central Roles in Inflammatory Responses of Toll-Like Receptor 2-Stimulated Neutrophils

2004 • 138 citations

Role of PI3-kinase–dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival

2002 • 115 citations

Effects of cell purification methods on CD11b and l-selectin expression as well as the adherence and activation of leucocytes

1995 • 108 citations

A1 Is a Constitutive and Inducible Bcl-2 Homologue in Mature Human Neutrophils

1998 • 101 citations

Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis

2001 • 99 citations

The Role of Interleukin-1β in Direct and Toll-Like Receptor 4-Mediated Neutrophil Activation and Survival

2004 • 97 citations

Mechanisms involved in interleukin‐15‐induced suppression of human neutrophil apoptosis: role of the anti‐apoptotic Mcl‐1 protein and several kinases including Janus kinase‐2, p38 mitogen‐activated protein kinase and extracellular signal‐regulated kinases‐1/2

2002 • 87 citations

Inhibition of Neutrophil Apoptosis by Type 1 IFN Depends on Cross-Talk Between Phosphoinositol 3-Kinase, Protein Kinase C-δ, and NF-κB Signaling Pathways

2003 • 85 citations

A rapid single‐laser flow cytometric method for discrimination of early apoptotic cells in a heterogenous cell population

1999 • 85 citations

p38 Mitogen‐activated protein kinase and phosphatidylinositol 3‐kinase activities have opposite effects on human neutrophil apoptosis

2001 • 82 citations

C5a delays apoptosis of human neutrophils via an extracellular signal‐regulated kinase and Bad‐mediated signalling pathway

2004 • 71 citations

Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis

2001 • 69 citations

Sodium butyrate delays neutrophil apoptosis: role of protein biosynthesis in neutrophil survival

1996 • 67 citations

Intracellular Pool of IL-10 Receptors in Specific Granules of Human Neutrophils: Differential Mobilization by Proinflammatory Mediators

2001 • 63 citations

Porphyromonas gingivalis lipopolysaccharide delays human polymorphonuclear leukocyte apoptosis in vitro

1999 • 58 citations

INCREASED LEVELS OF APOPTOSIS OF LEUKOCYTE SUBSETS IN CULTURED PBMCs COMPARED TO WHOLE BLOOD AS SHOWN BY ANNEXIN V BINDING: RELEVANCE TO CYTOKINE PRODUCTION

2000 • 53 citations

Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis

2001 • 53 citations

Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis.

2001 • 50 citations

Lipopolysaccharide Protects Polymorphonuclear Leukocytes from Apoptosis via Tyrosine Phosphorylation-Dependent Signal Transduction Pathways

1998 • 44 citations

Oxidants from phagocytes: agents of defense and destruction

1984 • 38 citations

Granulocyte apoptosis and the control of inflammation

1995 • 31 citations

Regulation of Neutrophil Apoptosis by Tumor Necrosis Factor-α: Requirement for TNFR55 and TNFR75 for Induction of Apoptosis In Vitro

1997 • 29 citations

Oncostatin M Production and Regulation by Human Polymorphonuclear Neutrophils

1999 • 14 citations