The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

Control of apoptosis by Rel/NF-κB transcription factors

1999 • 1,204 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator

1999 • 1,123 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

2001 • 1,048 citations

Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization

1999 • 1,030 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

NF-κB signaling pathways in mammalian and insect innate immunity

2001 • 892 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

1999 • 827 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

2001 • 807 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

1998 • 710 citations

Baff Mediates Survival of Peripheral Immature B Lymphocytes

2000 • 705 citations

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

2000 • 685 citations

DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES

1999 • 636 citations

Limb and Skin Abnormalities in Mice Lacking IKKα

1999 • 609 citations

Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice

1997 • 590 citations

Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

1999 • 581 citations

Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in theplt/pltmouse

2000 • 580 citations

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

2002 • 558 citations

Lymphotoxin α/β and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

1999 • 552 citations

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

2000 • 523 citations

The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus

1999 • 485 citations

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1999 • 475 citations

IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development

2001 • 469 citations

Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice

2000 • 469 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.

1995 • 436 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

2001 • 407 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti

2000 • 395 citations

Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice

1997 • 365 citations

IKKα controls formation of the epidermis independently of NF-κB

2001 • 357 citations

Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment

2001 • 260 citations

Splenic T Zone Development Is B Cell Dependent

2001 • 245 citations

Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines

2001 • 221 citations

The Earliest Stages of B Cell Development Require a Chemokine Stromal Cell-Derived Factor/Pre-B Cell Growth-Stimulating Factor

2001 • 218 citations

The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes

1999 • 217 citations

RelB Cellular Regulation and Transcriptional Activity Are Regulated by p100

2002 • 213 citations

Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation

2000 • 202 citations

Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I

2001 • 200 citations

Chemokines in lymphopoiesis and lymphoid organ development

2001 • 187 citations

Iκb Kinase α Is Essential for Mature B Cell Development and Function

2001 • 186 citations

Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor.

1996 • 181 citations

Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells.

1993 • 170 citations

Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors.

1995 • 146 citations

Highly-expressed p100/p52 (NFKB2) sequesters other NF-kappa B-related proteins in the cytoplasm of human breast cancer cells.

1995 • 126 citations

Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression.

1995 • 118 citations

Regulation of NF-κB activity by IκB-related proteins in adenocarcinoma cells

1999 • 113 citations

Transcriptional Regulation of NF-κB2: Evidence for κB-Mediated Positive and Negative Autoregulation

1994 • 112 citations

Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs

2002 • 105 citations

Visualization of Lymphotoxin-β and Lymphotoxin-β Receptor Expression in Mouse Embryos

2002 • 84 citations

Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent.

1996 • 83 citations

Specific inhibition of RelB/p52 transcriptional activity by the C-terminal domain of p100.

1995 • 80 citations

Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis.

1999 • 61 citations

Discrete Signaling Regions in the Lymphotoxin-β Receptor for Tumor Necrosis Factor Receptor-associated Factor Binding, Subcellular Localization, and Activation of Cell Death and NF-κB Pathways

2000 • 59 citations

Involvement of Distinct Cellular Compartments in the Abnormal Lymphoid Organogenesis in Lymphotoxin-α-Deficient Mice and Alymphoplasia (aly) Mice Defined by the Chimeric Analysis

1999 • 54 citations

TNF receptor signal transduction. Ligand-dependent stimulation of a serine protein kinase activity associated with (CD120a) TNFR60.

1994 • 48 citations

The NF- B Activation Pathway:A Paradigm in Information Transfer from Membrane to Nucleus

1999 • 47 citations

Regulation of major histocompatibility complex class I expression by NF-κB-related proteins in breast cancer cells

1998 • 33 citations

Subcellular Redistribution of HTLV-I Tax Protein by NF-κB/Rel Transcription Factors

1994 • 32 citations

Expression profiling in knockout mice: lymphotoxin versus tumor necrosis factor in the maintenance of splenic microarchitecture

2001 • 12 citations