Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

Antibodies, a laboratory manual

1989 • 12,929 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Molecular Regulation of B Lymphocyte Response

1988 • 579 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

Dif, a dorsal-related gene that mediates an immune response in Drosophila

1993 • 464 citations

Autoregulation of I kappa B alpha activity.

1994 • 419 citations

NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

1992 • 415 citations

Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65

1991 • 410 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function

1990 • 325 citations

Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation

1994 • 275 citations

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation.

1993 • 261 citations

The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation.

1992 • 258 citations

High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro

1993 • 231 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

The mouse Pgk-1 gene promoter contains an upstream activator sequence

1991 • 200 citations

The inhibitory ankyrin and activator Rel proteins

1992 • 185 citations

Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line.

1995 • 162 citations

Functional and molecular characterization of single, (4‐hydroxy‐3‐nitrophenyl)acetyl (NP)‐specific, IgG₁⁺ B cells from antibody‐secreting and memory B cell pathways in the C57BL/6 immune response to NP

1992 • 159 citations

c-rel activates but v-rel suppresses transcription from kappa B sites.

1991 • 146 citations

Murine B cell proliferation and protection from apoptosis with an antibody against a 105-kD molecule: unresponsiveness of X-linked immunodeficient B cells.

1994 • 138 citations

Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation.

1994 • 125 citations

Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen.

1994 • 120 citations

Molecular Cloning and Characterization of a Novel Rel/NF-χB Family Member Displaying Structural and Functional Homology to NF-χB p50/p105

1992 • 102 citations

Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation

1994 • 101 citations

vRel is an inactive member of the Rel family of transcriptional activating proteins

1991 • 100 citations

Malignant transformation by mutant Rel proteins

1991 • 96 citations

Identification and analysis of all components of a gel retardation assay by combination with immunoblotting.

1993 • 94 citations

Activation of p56^lck by p72^syk through Physical Association and N-Terminal Tyrosine Phosphorylation†

1994 • 94 citations

The subunit composition of NF-kappa B complexes changes during B-cell development.

1994 • 93 citations

Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.

1994 • 91 citations

Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells.

1994 • 89 citations

Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel.

1992 • 87 citations

Role of Mercaptoethanol and Endotoxin in Stimulating B Lymphocyte Colony Formation in Vitro

1976 • 86 citations

Structure and autoregulation of the c-rel promoter.

1990 • 70 citations

[52] Simple screening procedure to detect gene targeting events in embryonic stem cells

1993 • 59 citations

Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B.

1993 • 56 citations

rel/NF-kappa B nuclear complexes that bind kB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells.

1993 • 55 citations

v-rel induces expression of three avian immunoregulatory surface receptors more efficiently than c-rel

1994 • 50 citations

Detection of c-rel-related transcripts in mouse hematopoietic tissues, fractionated lymphocyte populations, and cell lines.

1987 • 46 citations

The murine c-rel proto-oncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli.

1990 • 36 citations

Cross‐linking of surface IgM activates NF‐xB in B lymphocyte

1991 • 32 citations

Murine c-rel transcription is rapidly induced in T-cells and fibroblasts by mitogenic agents and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

1990 • 26 citations

Expression of the c-rel and c-myc proto-oncogenes in avian tissues.

1989 • 23 citations

C-Rel: a multifunctional transcription factor ?

1994 • 10 citations