The Survival of Antigen-Stimulated T Cells Requires NFκB-Mediated Inhibition of p73 Expression

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

1997 • 1,324 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

2000 • 979 citations

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

2002 • 803 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Role of NF-κB in p53-mediated programmed cell death

2000 • 730 citations

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis

1999 • 721 citations

Role for the p53 homologue p73 in E2F-1-induced apoptosis

2000 • 700 citations

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

2002 • 676 citations

Transcriptional Cross Talk between NF-κB and p53

1999 • 590 citations

An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death

2000 • 461 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

2000 • 397 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Activation and inhibition of lymphocytes by costimulation

2002 • 332 citations

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation

2000 • 326 citations

The potential tumor suppressor p73 differentially regulates cellular p53 target genes.

1998 • 324 citations

DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes

2002 • 319 citations

p53 stabilization is decreased upon NFκB activation

2002 • 311 citations

The genetics of the E2F family of transcription factors: shared functions and unique roles

2002 • 301 citations

E2F1 and c-Myc Potentiate Apoptosis through Inhibition of NF-κB Activity that Facilitates MnSOD-Mediated ROS Elimination

2002 • 282 citations

Molecular mechanisms of activated T cell death in vivo

2002 • 276 citations

CD28 costimulation prevents cell death during primary T cell activation.

1996 • 270 citations

Activation and inhibition of lymphocytes by costimulation

2002 • 264 citations

Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-κB

1997 • 259 citations

Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor κB

1999 • 257 citations

E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways

1999 • 244 citations

Immunological adjuvants promote activated T cell survival via induction of Bcl-3

2001 • 228 citations

p53 family update: p73 and p63 develop their own identities.

2001 • 226 citations

RETRACTED: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens

1998 • 216 citations

The NF-κB Cascade Is Important in Bcl-xL Expression and for the Anti-Apoptotic Effects of the CD28 Receptor in Primary Human CD4+ Lymphocytes

2000 • 214 citations

It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation

2002 • 183 citations

c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function

1999 • 172 citations

Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector.

1995 • 160 citations

NF-κB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type

1999 • 159 citations

B Cell Growth Is Controlled by Phosphatidylinosotol 3-Kinase-Dependent Induction of Rel/NF-κB Regulated c-myc Transcription

2002 • 143 citations

NF-κB RelA (p65) Is Essential for TNF-α-Induced Fas Expression but Dispensable for Both TCR-Induced Expression and Activation-Induced Cell Death

2001 • 118 citations

The Transcriptional Repressor ZEB Regulates p73 Expression at the Crossroad between Proliferation and Differentiation

2001 • 117 citations

Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappa B activation

1997 • 113 citations

Strong TCR Ligation Without Costimulation Causes Rapid Onset of Fas-Dependent Apoptosis of Naive Murine CD4+ T Cells

1999 • 109 citations

In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis.

1999 • 93 citations

Fas ligand, death gene

1999 • 90 citations

Distinct Signal Thresholds for the Unique Antigen Receptor–Linked Gene Expression Programs in Mature and Immature B Cells

1999 • 89 citations

Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naïve T cells

2000 • 83 citations

Adenovirus-Mediated Expression of a Dominant Negative Mutant of p65/RelA Inhibits Proinflammatory Gene Expression in Endothelial Cells Without Sensitizing to Apoptosis

1998 • 82 citations

In Vivo Inhibition of NF-κB in T-Lineage Cells Leads to a Dramatic Decrease in Cell Proliferation and Cytokine Production and to Increased Cell Apoptosis in Response to Mitogenic Stimuli, But Not to Abnormal Thymopoiesis

1999 • 79 citations

p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: molecular mechanisms and implications for oncogenesis

1999 • 73 citations

The Human p73 Promoter: Characterization and Identification of Functional E2F Binding Sites

2002 • 46 citations

P16Ink4a tumor suppressor function in lung cancer cells involves cyclin-dependent kinase 2 inhibition by Cip/Kip protein redistribution.

2000 • 16 citations