Control of lymphocyte development by nuclear factor-κB

NF-κB regulation in the immune system

2002 • 3,804 citations

Signaling to NF-κB

2004 • 3,768 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

1999 • 1,464 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

B Cell Development Pathways

2001 • 1,185 citations

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

2000 • 1,171 citations

Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cells

2001 • 1,035 citations

Requirement for NF-κB in osteoclast and B-cell development

1997 • 994 citations

T-cell development and the CD4–CD8 lineage decision

2002 • 738 citations

BAFF: A fundamental survival factor for B cells

2002 • 694 citations

BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells

2002 • 674 citations

TACI-Ig Neutralizes Molecules Critical for B Cell Development and Autoimmune Disease

2001 • 611 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice

2000 • 579 citations

Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

2004 • 552 citations

BAFF/BLyS Receptor 3 Binds the B Cell Survival Factor BAFF Ligand through a Discrete Surface Loop and Promotes Processing of NF-κB2

2002 • 468 citations

NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti

2000 • 435 citations

Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti

2000 • 395 citations

CARMA1, BCL-10 and MALT1 in lymphocyte development and activation

2004 • 378 citations

TNF Family Member B Cell-Activating Factor (BAFF) Receptor-Dependent and -Independent Roles for BAFF in B Cell Physiology

2004 • 365 citations

PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling

2002 • 319 citations

Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling.

2005 • 314 citations

Cutting Edge: BLyS Enables Survival of Transitional and Mature B Cells Through Distinct Mediators

2002 • 309 citations

Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development

2003 • 300 citations

The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes

2002 • 288 citations

Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells

1999 • 285 citations

NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

2000 • 280 citations

Nuclear Factor κB–dependent Gene Expression Profiling of Hodgkin's Disease Tumor Cells, Pathogenetic Significance, and Link to Constitutive Signal Transducer and Activator of Transcription 5a Activity

2002 • 268 citations

Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-κB

1997 • 259 citations

B Lymphocytes Differentially Use the Rel and Nuclear Factor κB1 (NF-κB1) Transcription Factors to Regulate Cell Cycle Progression and Apoptosis in Quiescent and Mitogen-activated Cells

1998 • 250 citations

B Cell-Activating Factor Belonging to the TNF Family Acts through Separate Receptors to Support B Cell Survival and T Cell-Independent Antibody Formation

2004 • 249 citations

Protein Kinase C β Controls Nuclear Factor κB Activation in B Cells Through Selective Regulation of the IκB Kinase α

2002 • 239 citations

Differential dependence of CD4 ⁺ CD25 ⁺ regulatory and natural killer-like T cells on signals leading to NF-κB activation

2004 • 228 citations

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

2000 • 226 citations

Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines

2001 • 221 citations

A role for nuclear NF–κB in B–cell–specific demethylation of the Igκ locus

1996 • 216 citations

Prostate Stem Cell Antigen Is Overexpressed in Prostate Cancer Metastases

2005 • 211 citations

Mature T Cells Depend on Signaling through the IKK Complex

2003 • 210 citations

IKKβ Is Essential for Protecting T Cells from TNFα-Induced Apoptosis

2001 • 208 citations

An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis

1999 • 207 citations

Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells

1997 • 193 citations

Iκb Kinase α Is Essential for Mature B Cell Development and Function

2001 • 186 citations

Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells

2003 • 183 citations

IκB Kinase Signaling Is Essential for Maintenance of Mature B Cells

2002 • 179 citations

IKKβ Is Required for Peripheral B Cell Survival and Proliferation

2003 • 177 citations

Deletion of the Igκ Light Chain Intronic Enhancer/Matrix Attachment Region Impairs but Does Not Abolish VκJκ Rearrangement

1996 • 172 citations

A small molecule Abl kinase inhibitor induces differentiation of Abelson virus–transformed pre-B cell lines

2002 • 165 citations

Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-κB-Inducing Kinase

2000 • 164 citations

Nuclear Factor κb Is Required for the Development of Marginal Zone B Lymphocytes

2000 • 160 citations

Differential Requirement for Rel/Nuclear Factor κB Family Members in Natural Killer T Cell Development

2003 • 158 citations

Cytoplasmic Sequestration of Rel Proteins by IκBα Requires CRM1-Dependent Nuclear Export

2000 • 151 citations

Regulation of B Lymphocyte Development and Activation by Bruton's Tyrosine Kinase

2001 • 147 citations

The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects

1999 • 144 citations

Regulation of B-cell survival by BAFF-dependent PKCδ-mediated nuclear signalling

2004 • 143 citations

Massive Apoptosis of Thymocytes in T-Cell-Deficient Id1 Transgenic Mice

1999 • 133 citations

Defects in early B‐cell development: comparing the consequences of abnormalities in pre‐BCR signaling in the human and the mouse

2000 • 127 citations

Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function

2003 • 127 citations

Protein kinase C family functions in B-cell activation

2004 • 122 citations

Peptide-Induced Negative Selection of Thymocytes Activates Transcription of an NF-ΚB Inhibitor

2002 • 117 citations

Peripheral B‐cell maturation: the intersection of selection and homeostasis

2004 • 110 citations

The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

2002 • 110 citations

Immunobiology of the immature B cell: plasticity in the B‐cell antigen receptor‐induced response fine tunes negative selection

2000 • 106 citations

The anti‐apoptotic factor Bcl‐2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF

2004 • 96 citations

Activation-induced cell death in B lymphocytes

2000 • 87 citations

Impaired Precursor B Cell Differentiation in Bruton’s Tyrosine Kinase-Deficient Mice

2002 • 85 citations

Monoallelic gene expression: a repertoire of recurrent themes

2004 • 84 citations

Important Roles for E Protein Binding Sites within the Immunoglobulin κ Chain Intronic Enhancer in Activating Vκ Jκ Rearrangement

2004 • 74 citations

Corepression of RelA and c-Rel Inhibits Immunoglobulin κ Gene Transcription and Rearrangement in Precursor B Lymphocytes

1996 • 70 citations

Abnormal T lymphocyte development induced by targeted overexpression of IkappaB alpha.

1997 • 70 citations

Regulation of activation and recombination of the murine Igκ locus

2004 • 69 citations

An intact NF-κB signaling pathway is required for maintenance of mature B cell subsets

1999 • 67 citations

BCR signals target p27Kip1 and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells

2001 • 64 citations

Expression and induction of nuclear factor-kappa B-related proteins in thymocytes.

1995 • 62 citations

The role of Rel/NF-κB transcription factors in B lymphocyte survival

2003 • 59 citations

NF-kB inhibitor blocks B cell development at two checkpoints.

2004 • 56 citations

Helix-Loop-Helix Proteins Regulate Pre-TCR and TCR Signaling through Modulation of Rel/NF-κB Activities

2002 • 56 citations

Expression of Constitutively Active IκBβ in T Cells of Transgenic Mice: Persistent NF-κB Activity Is Required for T-Cell Immune Responses

1998 • 54 citations

Genetic dissection of antigen receptor induced-NF-?B activation

2004 • 43 citations

Inefficient ZAP-70 Phosphorylation and Decreased Thymic Selection In Vivo Result from Inhibition of NF-κB/Rel

2001 • 37 citations

Regulation of Developing B Cell Survival by RelA-Containing NF-κB Complexes

2003 • 35 citations

The N-terminal Nuclear Export Sequence of IκBα Is Required for RanGTP-dependent Binding to CRM1

2001 • 34 citations

I-κB Kinases α and β Have Distinct Roles in Regulating Murine T Cell Function

2002 • 26 citations

RelB reduces thymocyte apoptosis and regulates terminal thymocyte maturation

2002 • 22 citations

B‐cell homeostasis: digital survival or analog growth?

2004 • 21 citations

Transcription Factor NF-κB Regulates Igλ Light Chain Gene Rearrangement

2001 • 18 citations

Demethylation and the Establishment of Allelic Exclusion

1999 • 17 citations