The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

2002 • 910 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

2003 • 808 citations

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

1998 • 643 citations

Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase

1998 • 636 citations

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

2001 • 575 citations

Signal Transduction Mediated by the T Cell Antigen Receptor: The Role of Adapter Proteins

2002 • 565 citations

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

2000 • 487 citations

Immunodeficiency in Protein Kinase Cβ-Deficient Mice

1996 • 444 citations

Phosphoinositide 3-kinase signalling pathways

2006 • 443 citations

Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

2001 • 375 citations

Inactivation of Notch1 Impairs VDJβ Rearrangement and Allows pre-TCR-Independent Survival of Early αβ Lineage Thymocytes

2002 • 342 citations

Essential role of PDK1 in regulating cell size and development in mice

2002 • 322 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling

2002 • 319 citations

Development of αβ T cells in the human thymus

2002 • 266 citations

Protein kinase Cδ controls self-antigen-induced B-cell tolerance

2002 • 265 citations

T Cell Activation and the Cytoskeleton

2000 • 264 citations

Protein Kinase Cϵ Is Required for Macrophage Activation and Defense Against Bacterial Infection

2001 • 241 citations

Regulation of thymocyte differentiation: pre-TCR signals and β-selection

2002 • 225 citations

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

2003 • 192 citations

Essential Role of the Pre-T Cell Receptor in Allelic Exclusion of the T Cell Receptor β Locus

1997 • 146 citations

The S6 kinase Signaling Pathway In The Control of Development and Growth

2002 • 137 citations

Protein Kinase C-δ Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation

2002 • 131 citations

Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of thePig-agene

1998 • 111 citations

Phosphoinositide 3-kinases in T lymphocyte activation

2001 • 111 citations

Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status.

1993 • 94 citations

Intracellular Location and Cell Context-Dependent Function of Protein Kinase D

2003 • 91 citations

Different Functions of the GTPase Rho in Prothymocytes and Late Pre-T Cells

1997 • 88 citations

On the brink of becoming a T cell

2002 • 84 citations

Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio

2003 • 82 citations

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

2003 • 67 citations

AGC protein kinase phosphorylation and protein kinase C

2001 • 67 citations

The Gtpase Rho Controls a P53-Dependent Survival Checkpoint during Thymopoiesis

2000 • 61 citations

The GTPase Rac-1 Controls Cell Fate in the Thymus by Diverting Thymocytes from Positive to Negative Selection

2001 • 59 citations

Transgenic analysis of thymocyte signal transduction

2002 • 57 citations

Pre‐TCR signaling regulates IL‐7 receptor α expression promoting thymocyte survival at the transition from the double‐negative to double‐positive stage

2003 • 54 citations

AGC protein kinase phosphorylation and protein kinase C

2001 • 51 citations

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes

2001 • 49 citations

Co-ordination of the expression of the protein tyrosine kinase p56lck with the pre-T cell receptor during thymocyte development

2000 • 47 citations

PDK1 and PKB/Akt: Ideal Targets for Development of New Strategies to Structure‐Based Drug Design

2003 • 43 citations

The T cell antigen receptor activates phosphatidylinositol 3‐kinase‐regulated serine kinases protein kinase B and ribosomal S6 kinase 1

2000 • 41 citations

Regulation and function of serine kinase networks in lymphocytes

2003 • 23 citations

Regulation of Hematopoietic Cell Development and Activation by Adapter Proteins

2003 • 7 citations