TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Signaling to NF-κB

2004 • 3,768 citations

Toll-like receptors in innate immunity

2004 • 3,233 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

2001 • 2,027 citations

TNF-R1 Signaling: A Beautiful Pathway

2002 • 1,860 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

2000 • 1,801 citations

Signal transduction by tumor necrosis factor and its relatives

2001 • 1,623 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

1999 • 1,163 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

2001 • 807 citations

Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling

2003 • 692 citations

The Knockout Mouse Project

2004 • 605 citations

TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway

2000 • 589 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

1999 • 581 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

2000 • 523 citations

Sequential Activation of Signaling Pathways during Innate Immune Responses in Drosophila

2002 • 498 citations

Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice

2000 • 469 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway

2003 • 385 citations

Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β

2004 • 365 citations

Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responses

2001 • 302 citations

Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR

2003 • 300 citations

Induction of p100 Processing by NF-κB-inducing Kinase Involves Docking IκB Kinase α (IKKα) to p100 and IKKα-mediated Phosphorylation

2004 • 280 citations

Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol

2002 • 279 citations

Feedback control of the protein kinase TAK1 by SAPK2a/p38

2003 • 277 citations

Immune Activation of NF-κB and JNK Requires Drosophila TAK1

2003 • 266 citations

Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling

2003 • 263 citations

JunD Mediates Survival Signaling by the JNK Signal Transduction Pathway

2003 • 253 citations

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells

2003 • 247 citations

The Nature of the 660-Kilometer Upper-Mantle Seismic Discontinuity from Precursors to the PP Phase

1996 • 245 citations

Role of TAK1 and TAB1 in BMP signaling in early Xenopus development

1998 • 234 citations

IAP Suppression of Apoptosis Involves Distinct Mechanisms: the TAK1/JNK1 Signaling Cascade and Caspase Inhibition

2002 • 222 citations

Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway

2001 • 195 citations

Targeting of TAK1 by the NF-κB protein Relish regulates the JNK-mediated immune response in Drosophila

2004 • 189 citations

TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide

2000 • 177 citations

RelB/p50 Dimers Are Differentially Regulated by Tumor Necrosis Factor-α and Lymphotoxin-β Receptor Activation

2003 • 147 citations

TAB2 Is Essential for Prevention of Apoptosis in Fetal Liver but Not for Interleukin-1 Signaling

2003 • 123 citations

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis

2002 • 99 citations

Hrs, a Mammalian Master Molecule in Vesicular Transport and Protein Sorting, Suppresses the Degradation of ESCRT Proteins Signal Transducing Adaptor Molecule 1 and 2

2005 • 51 citations

Expression of TAK1, a mediator of TGF-β and BMP signaling, during mouse embryonic development

2003 • 36 citations