The two NF-κB activation pathways and their role in innate and adaptive immunity

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

2001 • 1,305 citations

A chemokine-driven positive feedback loop organizes lymphoid follicles

2000 • 1,220 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

2001 • 1,048 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

2001 • 807 citations

BAFF: A fundamental survival factor for B cells

2002 • 694 citations

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

2000 • 685 citations

BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells

2002 • 674 citations

DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES

1999 • 636 citations

Disruption of Signaling by Yersinia Effector YopJ, a Ubiquitin-Like Protein Protease

2000 • 549 citations

The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers

1993 • 506 citations

The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

2003 • 482 citations

Direct Phosphorylation of IκB by IKKα and IKKβ: Discrimination Between Free and NF-κB-Bound Substrate

1998 • 450 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

CD40 regulates the processing of NF-kappaB2 p100 to p52

2002 • 435 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti

2000 • 395 citations

RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.

1992 • 375 citations

The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4

2004 • 362 citations

NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria.

1999 • 334 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

A Drosophila IκB kinase complex required for Relish cleavage and antibacterial immunity

2000 • 306 citations

NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

1997 • 296 citations

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

1993 • 291 citations

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

2003 • 288 citations

NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

2000 • 280 citations

NF-κB Is a Central Regulator of the Intestinal Epithelial Cell Innate Immune Response Induced by Infection with Enteroinvasive Bacteria

1999 • 272 citations

Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment

2001 • 260 citations

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

2000 • 226 citations

Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines

2001 • 221 citations

RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF

2002 • 213 citations

The role of natural killer cells in host—parasite interactions

1995 • 209 citations

IKKβ Is Essential for Protecting T Cells from TNFα-Induced Apoptosis

2001 • 208 citations

Homing of antibody secreting cells

2003 • 205 citations

Regulation of secondary lymphoid organ development by the nuclear factor‐κB signal transduction pathway

2003 • 204 citations

Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I

2001 • 200 citations

Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells

1997 • 193 citations

Critical Roles for the Bcl-3 Oncoprotein in T Cell–Mediated Immunity, Splenic Microarchitecture, and Germinal Center Reactions

1997 • 179 citations

IKKβ Is Required for Peripheral B Cell Survival and Proliferation

2003 • 177 citations

I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.

1992 • 167 citations

Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-κB-Inducing Kinase

2000 • 164 citations

Nuclear Factor κb Is Required for the Development of Marginal Zone B Lymphocytes

2000 • 160 citations

Pulmonary epithelial cells are a source of IL-8 in the response to Mycobacterium tuberculosis: essential role of IL-1 from infected monocytes in a NF-kappa B-dependent network.

1999 • 149 citations

c-Rel is essential for B lymphocyte survival and cell cycle progression

1998 • 131 citations

The NF-kappa B family member RelB is required for innate and adaptive immunity to Toxoplasma gondii.

1999 • 130 citations

Lymphotoxin and lipopolysaccharide induce NF‐κB‐p52 generation by a co‐translational mechanism

2003 • 127 citations

Pulmonary Epithelial Cells are a Source of IL-8 in the Response to Mycobacterium tuberculosis: Essential Role of IL-1 from Infected Monocytes in a NF-κB-Dependent Network

1999 • 122 citations

The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

1996 • 120 citations

Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen.

1994 • 120 citations

The NF-κB Family Member RelB Is Required for Innate and Adaptive Immunity toToxoplasma gondii

1999 • 119 citations

Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs

2002 • 105 citations

Cutting Edge: Identification of c-Rel-Dependent and -Independent Pathways of IL-12 Production During Infectious and Inflammatory Stimuli

2002 • 105 citations

Distinct activities of p52/NF-kappa B required for proper secondary lymphoid organ microarchitecture: functions enhanced by Bcl-3.

1999 • 73 citations

Distinct Activities of p52/NF-κB Required for Proper Secondary Lymphoid Organ Microarchitecture: Functions Enhanced by Bcl-3

1999 • 54 citations

Analysis of an Ethylnitrosourea-generated Mouse Mutation Defines a Cell Intrinsic Role of Nuclear Factor κB2 in Regulating Circulating B Cell Numbers

2002 • 52 citations

Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.

1999 • 31 citations

CD40 and its ligand in cell-mediated immunity

1998 • 15 citations

pH-dependent conformational change of gastrin

1974 • 6 citations