Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

1996 • 1,115 citations

Signal transduction through NF-κB

1998 • 1,103 citations

Osteopetrosis in mice lacking NF-κB1 and NF-κB2

1997 • 988 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation

1998 • 715 citations

NF-κB and Rel Proteins in Innate Immunity

1995 • 435 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice.

1996 • 391 citations

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient mice

1997 • 379 citations

An ancient system of host defense

1998 • 333 citations

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

1999 • 303 citations

NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

1997 • 296 citations

Pro-inflammatory signaling: Last pieces in the NF-κB puzzle?

1998 • 280 citations

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

1997 • 275 citations

Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival

1997 • 254 citations

"The good, the bad, and the ugly." The role of chemokines in models of human disease.

1996 • 250 citations

Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation.

1995 • 240 citations

Role for macrophage inflammatory protein-2 in lipopolysaccharide-induced lung injury in rats.

1996 • 200 citations

Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice.

1996 • 199 citations

Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells

1997 • 193 citations

Regulation of Immune Responses by NF-κB/Rel Transcription Factors

1998 • 193 citations

Myeloid Development Is Selectively Disrupted in PU.1 Null Mice

1998 • 191 citations

Chronic Inflammation and Susceptibility to Bacterial Infections in Mice Lacking the Polypeptide (p)105 Precursor (NF-κB1) but Expressing p50

1998 • 147 citations

A Critical Role for the RelA Subunit of Nuclear Factor κB in Regulation of Multiple Immune-response Genes and in Fas-induced Cell Death

1999 • 147 citations

The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects

1999 • 144 citations

The Genetic Basis of Chronic Granulomatous Disease

1994 • 139 citations

Prevention of Hepatic Apoptosis and Embryonic Lethality in RelA/TNFR-1 Double Knockout Mice

2000 • 132 citations

p50–NF-κB Complexes Partially Compensate for the Absence of RelB: Severely Increased Pathology in p50−/−relB−/−Double-knockout Mice

1997 • 112 citations

Depletion of alveolar macrophages decreases neutrophil chemotaxis to Pseudomonas airspace infections

1996 • 111 citations

Role of the type 1 TNF receptor in lung inflammation after inhalation of endotoxin orPseudomonas aeruginosa

1999 • 105 citations

Modulation of cell membrane potential in cultured vascular endothelium

1996 • 95 citations

CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits.

1993 • 91 citations

Signal-Induced Degradation of IκBα: Association with NF-κB and the PEST Sequence in IκBα Are Not Required

1996 • 90 citations

Effects of CD18 Deficiency on the Emigration of Murine Neutrophils During Pneumonia

1999 • 89 citations

Adhesion Molecules and Cellular Biomechanical Changes in Acute Lung Injury

1999 • 84 citations

Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.

1994 • 64 citations

The p65 subunit of NF-kappa B is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3.

1999 • 58 citations

Roles of Tumor Necrosis Factor Receptor Signaling during MurineEscherichia coliPneumonia

2000 • 44 citations

The p65 Subunit of NF-κB Is Redundant with p50 During B Cell Proliferative Responses, and Is Required for Germline CH Transcription and Class Switching to IgG3

1999 • 42 citations

Combinatorial requirements for adhesion molecules in mediating neutrophil emigration during bacterial peritonitis in mice

1998 • 34 citations

Activated Alveolar Macrophage-Derived Nitric Oxide Predicts the Development of Lung Damage After Marrow Transplantation in Mice

1999 • 28 citations

TNF mediates lung leak, but not neutrophil accumulation, in lungs of rats given IL-1 intratracheally.

1997 • 24 citations

Innate immunity

1998 • 20 citations

Myeloid Development Is Selectively Disrupted in PU.1 Null Mice

1998 • 15 citations