Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Oncogenes and signal transduction

1991 • 2,816 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Transcription activation by the adenovirus E1a protein

1989 • 667 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

A vector for expressing GAL4(1–147) fusions tn mammalian cells

1989 • 558 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase

1991 • 491 citations

Substrates for p34cdc2: In vivo veritas?

1990 • 472 citations

A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel

1989 • 466 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

1990 • 437 citations

Functional antagonism between c-Jun and MyoD proteins: A direct physical association

1992 • 424 citations

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity

1992 • 387 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

1991 • 380 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex

1992 • 361 citations

Control of transcription factors by signal transduction pathways: the beginning of the end

1992 • 360 citations

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

1992 • 343 citations

MAP kinase by any other name smells just as sweet

1992 • 341 citations

jun:Oncogene and Transcription Factor

1990 • 337 citations

PROKARYOTIC SIGNAL TRANSDUCTION MEDIATED BY SENSOR AND REGULATOR PROTEIN PAIRS

1989 • 295 citations

FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1.

1993 • 274 citations

Different requirements for formation of Jun: Jun and Jun: Fos complexes.

1989 • 272 citations

pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.

1990 • 256 citations

Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.

1992 • 250 citations

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1992 • 239 citations

Biochemical analysis of transcriptional activation by Jun: Differential activity of c- and v-Jun

1989 • 225 citations

Control of c-Jun activity by interaction of a cell-specific inhibitor with regulatory domain δ: Differences between v- and c-Jun

1990 • 212 citations

A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum

1988 • 187 citations

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.

1990 • 175 citations

Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation.

1991 • 155 citations

Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions

2013 • 146 citations

Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.

1992 • 138 citations

Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy.

1993 • 128 citations

The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells.

1991 • 126 citations

Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.

1992 • 123 citations

Identification in chickens of an evolutionarily conserved cellular ets-2 gene (c-ets-2) encoding nuclear proteins related to the products of the c-ets proto-oncogene.

1988 • 122 citations

Conserved motifs in Fos and Jun define a new class of activation domain.

1992 • 120 citations

Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity.

1992 • 109 citations

v-Src and EJ Ras alleviate repression of c-Jun by a cell-specific inhibitor

1991 • 81 citations

Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.

1992 • 78 citations

Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukaemic cells.

1993 • 65 citations

c-abl has a sequence-specific enhancer binding activity

1992 • 58 citations

The cell-type-specific activator region of c-Jun juxtaposes constitutive and negatively regulated domains.

1992 • 54 citations

Mutations in the Jun delta region suggest an inverse correlation between transformation and transcriptional activation.

1992 • 44 citations

v-jun is a transcriptional activator, but not in all cell-lines

1988 • 34 citations