The DNA Binding Activity of Metal Response Element-binding Transcription Factor-1 Is Activated in vivo and in Vitro by Zinc, but Not by Other Transition Metals

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

Biochemistry of metallothionein

1988 • 1,222 citations

[69] Overview of metallothionein

1991 • 793 citations

Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.

1995 • 746 citations

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

1994 • 624 citations

Cadmium, Gene Regulation, and Cellular Signalling in Mammalian Cells

1997 • 530 citations

Zinc fingers and other metal-binding domains. Elements for interactions between macromolecules.

1990 • 509 citations

The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression.

1994 • 489 citations

ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration.

1996 • 447 citations

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

1984 • 424 citations

Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter.

1993 • 382 citations

Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis

1987 • 382 citations

Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse.

1993 • 381 citations

Regulation of metallothionein genes by heavy metalsappears to be mediated by a zinc-sensitive inhibitor that interacts with aconstitutively active transcription factor, MTF-1.

1994 • 351 citations

Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange.

1994 • 334 citations

Enhanced Sensitivity to Oxidative Stress in Cultured Embryonic Cells from Transgenic Mice Deficient in Metallothionein I and II Genes

1995 • 302 citations

Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements

1994 • 265 citations

Measurement of protein‐DNA interaction parameters by electrophoresis mobility shift assay

1989 • 262 citations

A consensus zinc finger peptide: design, high-affinity metal binding, a pH-dependent structure, and a His to Cys sequence variant

1991 • 237 citations

Oxidative Stress Activates Metal-responsive Transcription Factor-1 Binding Activity

1996 • 237 citations

Cadmium evokes inositol polyphosphate formation and calcium mobilization

1989 • 212 citations

Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1

1994 • 197 citations

Functional domains of the heavy metal-responsive transcription regulator MTF-1

1995 • 155 citations

Coordinate regulation of mouse metallothionein I and II genes by heavy metals and glucocorticoids.

1985 • 146 citations

Reversible Activation of Mouse Metal Response Element-Binding Transcription Factor 1 DNA Binding Involves Zinc Interaction with the Zinc Finger Domain

1997 • 127 citations

Glutathione Mercaptides as Transport Forms of Metals

1994 • 126 citations

On the metal ion specificity of zinc finger proteins

1989 • 123 citations

Transgenic Mice That Overexpress Metallothionein-I Resist Dietary Zinc Deficiency

1996 • 115 citations

Copper(I) transfer into metallothionein mediated by glutathione

1993 • 114 citations

A copper-thiolate polynuclear cluster in the ACE1 transcription factor.

1991 • 113 citations

Enhanced Effectiveness of Copper Ion Buffering by CUP1 Metallothionein Compared with CRS5 Metallothionein in Saccharomyces cerevisiae

1996 • 105 citations

Structure and function of the Zn(II) binding site within the DNA-binding domain of the GAL4 transcription factor.

1989 • 89 citations

Metal binding properties of single amino acid deletion mutants of zinc finger peptides: studies using cobalt(II) as a spectroscopic probe

1993 • 54 citations

Metal-dependent binding of a nuclear factor to the rat metallothionein-I promoter

1990 • 49 citations

Cd2+-induced c-myc mRNA accumulation in NRK-49F cells is blocked by the protein kinase inhibitor H7 but not by HA1004, indicating that protein kinase C is a mediator of the response

1993 • 47 citations

Cadmium-113 NMR studies of the DNA binding domain of the mammalian glucocorticoid receptor

1990 • 47 citations

Metal-responsive Elements of the Rainbow Trout Metallothionein-B Gene Function for Basal and Metal-induced Activity

1995 • 43 citations

Induction of metallothionein synthesis by cadmium and zinc in cultured rabbit kidney cells (RK-13)

1993 • 33 citations

Stimulation of myosin light-chain kinase by Cd2+ and Pb2+

1995 • 28 citations

Functional analyses of promoter elements responsible for the differential expression of the human metallothionein (MT)-IG and MT-IF genes

1991 • 24 citations