Heme Oxygenase-2 Is a Hemoprotein and Binds Heme through Heme Regulatory Motifs That Are Not Involved in Heme Catalysis

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

Microsomal Heme Oxygenase

1969 • 1,348 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

1986 • 748 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

The Molar Light Absorption of Pyridine Ferroprotoporphrin (Pyridine Haemochromogen).

1953 • 508 citations

Redox regulation of tyrosine phosphorylation in human spermatozoa and its role in the control of human sperm function

1995 • 456 citations

Cloning and expression of cDNA for rat heme oxygenase.

1985 • 451 citations

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

1992 • 368 citations

Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.

1992 • 344 citations

Functional dissection and sequence of yeast HAP1 activator

1989 • 309 citations

Evidence suggesting that the two forms of heme oxygenase are products of different genes.

1988 • 288 citations

Heme binds to a short sequence that serves a regulatory function in diverse proteins.

1995 • 285 citations

Regulation by Heme of Mitochondrial Protein Transport Through a Conserved Amino Acid Motif

1993 • 279 citations

Heme Oxygenase: Clinical Applications and Functions

1992 • 264 citations

Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform.

1986 • 260 citations

Rat liver heme oxygenase. High level expression of a truncated soluble form and nature of the meso-hydroxylating species.

1993 • 251 citations

Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae.

1987 • 232 citations

The nif promoters of Klebsiella pneumoniae have a characteristic primary structure

1983 • 223 citations

Nucleotide sequence and organization of the rat heme oxygenase gene.

1987 • 210 citations

The absorption spectra, magnetic moments and the binding of iron in some haemoproteins

1961 • 202 citations

The Association Rate Constant for Heme Binding to Globin Is Independent of Protein Structure

1996 • 200 citations

Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase.

1991 • 200 citations

Carbon monoxide: a role in carotid body chemoreception.

1995 • 194 citations

In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: Differential distribution of isozyme 1 and 2

1992 • 191 citations

Human heme oxygenase-2: Characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal

1992 • 184 citations

Developmental expression of heme oxygenase isozymes in rat brain. Two HO-2 mRNAs are detected.

1990 • 166 citations

The FixL protein of Rhizobium meliloti can be separated into a heme-binding oxygen-sensing domain and a functional C-terminal kinase domain.

1992 • 165 citations

Corticosterone Regulates Heme Oxygenase‐2 and NO Synthase Transcription and Protein Expression In Rat Brain

1994 • 148 citations

Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2.

1990 • 147 citations

Nucleotide sequence of katG, encoding catalase HPI of Escherichia coli

1988 • 140 citations

Stability of Myoglobin: A Model for the Folding of Heme Proteins

1994 • 132 citations

The Binding of Thyroxine by Serum Albumin as Measured by Fluorescence Quenching

1966 • 132 citations

CYP1 (HAP1) regulator of oxygen-dependent gene expression in yeast

1988 • 128 citations

Regulation of heme oxygenase-2 by glucocorticoids in neonatal rat brain: characterization of a functional glucocorticoid response element

1997 • 125 citations

A protein of the Z class of liver cytosolic proteins in the rat that preferentially binds heme.

1985 • 120 citations

The structure, organization and differential expression of the gene encoding rat heme oxygenase-2

1994 • 117 citations

Expression and characterization of truncated human heme oxygenase (hHO-1) and a fusion protein of hHO-1 with human cytochrome P450 reductase

1995 • 113 citations

Identification of Histidine 25 as the Heme Ligand in Human Liver Heme Oxygenase

1994 • 102 citations

Spectral studies on the denaturation of myoglobin

1968 • 98 citations

Heme Oxygenase-2

1995 • 85 citations

Promoters regulated by the glnG (ntrC) and nifA gene products share a heptameric consensus sequence in the -15 region.

1983 • 81 citations

Proteins from eight eukaryotic cytochrome P-450 families share a segmented region of sequence similarity.

1988 • 80 citations

Characterization of a cDNA-encoding rabbit brain heme oxygenase-2 and identification of a conserved domain among mammalian heme oxygenase isozymes: Possible heme-binding site?

1991 • 74 citations

Distribution of constitutive (HO-2) and heat-inducible (HO-1) heme oxygenase isozymes in rat testes: HO-2 displays stage-specific expression in germ cells.

1995 • 72 citations

Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells.

1988 • 72 citations

Demonstration That Histidine-25, But Not Histidine-132, Is the Axial Heme Ligand in Rat Heme Oxygenase-1

1995 • 59 citations

Detection of 10 variants of biliverdin reductase in rat liver by two-dimensional gel electrophoresis

1989 • 55 citations

Heme Oxygenase (HO-1): His-132 Stabilizes a Distal Water Ligand and Assists Catalysis

1996 • 50 citations

Domains of Rat Heme Oxygenase-2: The Amino Terminus and Histidine 151 Are Required for Heme Oxidation

1993 • 45 citations

Cloning, sequencing and expression of cDNA for chick liver haem oxygenase. Comparison of avian and mammalian cDNAs and deduced proteins

1991 • 39 citations

Multiple Transcripts Encoding Heme Oxygenase-2 in Rat Testis: Developmental and Cell-Specific Regulation of Transcripts and Protein1

1995 • 36 citations

Interaction of Fe-protoporphyrin IX and heme analogues with purified recombinant heme oxygenase-2, the constitutive isozyme of the brain and testes

1994 • 32 citations

The 3' flanking region of the human erythropoietin-encoding gene contains nitrogen-regulatory/oxygen-sensing consensus sequences and tissue-specific transcriptional regulatory elements

1993 • 16 citations

Structural studies on bovine spleen heme oxygenase

1990 • 12 citations

Heme binding and substrate-protected cysteine residues in P-450cam

1983 • 11 citations

Deleted Work

1955 • 0 citations