Importance of protein thiols during N-methyl-N′-nitro-N-nitrosoguanidine toxicity in primary rat hepatocytes

Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

1970 • 500 citations

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

1985 • 419 citations

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

1984 • 411 citations

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

1984 • 376 citations

Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity.

1985 • 310 citations

Na+ and K+ transport damage induced by oxygen free radicals in human red cell membranes.

1983 • 175 citations

High-affinity nitrosamine dealkylase system in rat liver microsomes and its induction by fasting.

1983 • 160 citations

Cell calcium, vitamin E, and teh thiol redox system in cytocoxicity

1989 • 123 citations

Mechanism of chemical-induced toxicity

1985 • 82 citations

Intervention in free radical mediated hepatotoxicity and lipid peroxidation by indole-3-carbinol

1988 • 66 citations

Toxicity of methylating agents in isolated hepatocytes

1988 • 31 citations

Relative contributions of protein sulfhydryl loss and lipid peroxidation to allyl alcohol-induced cytotoxicity in isolated rat hepatocytes

1989 • 30 citations

Mechanisms of chemical mediated cytotoxicity and chemoprotection in isolated rat hepatocytes

1991 • 27 citations

Protection against carbon tetrachloride hepatotoxicity by pretreatment with indole-3-carbinol

1987 • 25 citations

Protection against carbon tetrachloride hepatotoxicity by 5,10-dihydroindeno[1,2-b]indole, a potent inhibitor of lipid peroxidation

1988 • 24 citations

Cytotoxicity of phenazine methosulfate in isolated rat hepatocytes is associated with superoxide anion production, thiol oxidation and alterations in intracellular calcium ion homeostasis

1986 • 17 citations

Calcium transport, thiol status, and hepatotoxicity followingN‐nitrosodimethylamine exposure in mice

1988 • 16 citations

Nature of N-nitrosodimethylamine demethylase

1984 • 7 citations

Studies on calcium transport during carbon tetrachloride mediated hepatotoxicity in mice

1988 • 3 citations

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