Activation of the Chicken Metallothionein Promoter by Metals and Oxidative Stress in Cultured Cells and Transgenic Mice

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Oxidative mechanisms in the toxicity of metal ions

1995 • 4,127 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1988 • 1,699 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

1991 • 1,432 citations

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

1985 • 1,052 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Preservation of hamster oocytes to assay the fertilizing capacity of human spermatozoa

1982 • 653 citations

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

1994 • 624 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression.

1994 • 489 citations

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

1984 • 424 citations

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

1989 • 423 citations

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.

1990 • 422 citations

Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter.

1993 • 382 citations

Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences

1985 • 353 citations

Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.

1992 • 353 citations

Regulation of metallothionein genes by heavy metalsappears to be mediated by a zinc-sensitive inhibitor that interacts with aconstitutively active transcription factor, MTF-1.

1994 • 351 citations

Regulation, linkage, and sequence of mouse metallothionein I and II genes.

1984 • 335 citations

Enzyme-catalysed conjugations of glutathione with unsaturated compounds

1967 • 324 citations

Tissue‐specific regulation of zinc metabolism and metallothionein genes by interleukin 1

1988 • 314 citations

Enhanced Sensitivity to Oxidative Stress in Cultured Embryonic Cells from Transgenic Mice Deficient in Metallothionein I and II Genes

1995 • 302 citations

A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene.

1988 • 297 citations

Sp1 binds to promoter sequences and activates herpes simplex virus ‘immediate-early’ gene transcription in vitro

1985 • 289 citations

Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements

1994 • 265 citations

Endotoxin induction of murine metallothionein gene expression.

1990 • 239 citations

Oxidative Stress Activates Metal-responsive Transcription Factor-1 Binding Activity

1996 • 237 citations

Increase in metallothionein produced by chemicals that induce oxidative stress

1991 • 232 citations

Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.

1993 • 230 citations

Molecular Biology of Metallothionein Gene Expression

1987 • 214 citations

Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1

1994 • 197 citations

Interleukin 1 regulates human metallothionein gene expression.

1985 • 185 citations

Constitutive and metal-inducible protein:DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting.

1988 • 176 citations

Transgenic Mice That Overexpress Metallothionein-I Are Protected from Cadmium Lethality and Hepatotoxicity

1995 • 156 citations

Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.

1984 • 153 citations

Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

1994 • 152 citations

Transgenic Mice That Overexpress Metallothionein-I Resist Dietary Zinc Deficiency

1996 • 115 citations

Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression.

1994 • 97 citations

Yeast KEX2 Protease Has the Properties of a Human Proalbumin Converting Enzyme

1987 • 85 citations

Variation in enzymatic transient gene expression assays

1989 • 84 citations

Induction of hepatic metallothionein by nonmetallic compounds associated with acute-phase response in inflammation

1991 • 74 citations

Metallothionein in Biology and Medicine

1991 • 72 citations

Induction of several acute-phase protein genes by heavy metals: a new class of metal-responsive genes

1991 • 62 citations

Induction of hepatic metallothionein by paraquat

1992 • 55 citations

Expression of the haemopexin-transport system in cultured mouse hepatoma cells. Links between haemopexin and iron metabolism

1988 • 49 citations

Cooperative Interaction Between Ets and AP-1 Transcription Factors Regulates Induction of Glutathione S-Transferase Ya Gene Expression

1994 • 43 citations

Corticosterone Enhances the Zinc and Interleukin-6-Mediated Induction of Metallothionein in Cultured Rat Hepatocytes

1993 • 42 citations

Induction of metallothionein by diethyl maleate

1992 • 41 citations

Optimized assays for quantifying transient expressions of co-transfected beta-galactosidase and CAT reporter genes.

1992 • 39 citations

Molecular cloning of chicken metallothionein. Deduction of the complete amino add sequence and analysis of expression using cloned cDNA

1988 • 36 citations

Induction of hepatic metallothionein by intraperitoneal metal injection: an associated inflammatory response

1990 • 36 citations

[63] Induction of metallothionein in rats

1991 • 36 citations

Cloning and expression of an avian metallothionein-encoding gene

1989 • 34 citations

Examination of potential mechanism(s) of metallothionein induction by diethyl maleate

1992 • 19 citations

Evolution of avian metallothionein: DNA sequence analyses of the Turkey metallothionein gene and metallothionein cDNAs from pheasant and quail

1993 • 14 citations

Automation of a chloramphenicol acetyltransferase assay

1990 • 10 citations