Constitutive and metal-inducible protein:DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Genomic sequencing.

1984 • 8,343 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

METALLOTHIONEIN

1986 • 1,606 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins

1985 • 1,248 citations

Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region

1985 • 1,244 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen

1987 • 969 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

Specific DNA binding of GAL4, a positive regulatory protein of yeast

1985 • 767 citations

An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter

1985 • 763 citations

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

1987 • 762 citations

Activation of the AIDS Retrovirus Promoter by the Cellular Transcription Factor, Sp1

1986 • 741 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

Multiple specific contacts between a mammalian transcription factor and its cognate promoters

1984 • 565 citations

A drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene

1984 • 534 citations

Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences

1983 • 477 citations

Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene

1982 • 464 citations

Metallothioneins: Proteins in search of function

1985 • 445 citations

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

1984 • 424 citations

Bidirectional SV40 Transcription Mediated by Tandem Sp1 Binding Interactions

1985 • 413 citations

Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring

1982 • 379 citations

Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences

1985 • 353 citations

Stable reduction of thymidine kinase activity in cells expressing high levels of anti-sense RNA

1985 • 334 citations

Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids

1984 • 331 citations

Structure of mouse metallothionein-I gene and its mRNA

1981 • 301 citations

Sp1 binds to promoter sequences and activates herpes simplex virus ‘immediate-early’ gene transcription in vitro

1985 • 289 citations

Regulation of metallothionein–thymidine kinase fusion plasmids injected into mouse eggs

1982 • 283 citations

The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells

1982 • 265 citations

Specific interaction between a transcription factor and the upstream element of the adenovirus-2 major late promoter.

1985 • 195 citations

Detection of factors that interact with the human β-interferon regulatory region in vivo by DNAase I footprinting

1986 • 188 citations

Regulation of a metallothionein-growth hormone hybrid gene in bovine papilloma virus.

1983 • 168 citations

Duplicated heavy metal control sequences of the mouse metallothionein-I gene.

1984 • 167 citations

The major late transcription factor binds to and activates the mouse metallothionein I promoter.

1987 • 160 citations

Contacts between Escherichia coli RNA polymerase and a lac operon promoter.

1978 • 148 citations

Competition for cellular factors that activate metallothionein gene transcription

1984 • 107 citations

In Vivo Competition Between a Metallothionein Regulatory Element and the SV40 Enhancer

1986 • 106 citations

Regulation in Vitro of Metallothionein Gene Binding Factors

1987 • 101 citations

Structure and expression of two human metallothionein-I isoform genes and a related pseudogene.

1985 • 86 citations

MOLECULAR AND CYTOGENETIC CHARACTERIZATION OF A METALLOTHIONEIN GENE OF DROSOPHILA

1986 • 78 citations

Differentiation of murine erythroleukemia cells results in the rapid repression of vimentin gene expression.

1984 • 54 citations

Nucleotide Sequence Requirements for Transient Expression of Human Metallothionein-II_A-Thymidine Kinase Fusion Genes

1984 • 12 citations

[74] In Vivo footprinting of specific protein-DNA interactions

1987 • 8 citations