Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system.

[4] Isolation and use of liver cells

1978 • 1,230 citations

High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides

1980 • 1,179 citations

Intracellular phospholipases A

1980 • 989 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

ROLE OF REVERSIBLE OXIDATION-REDUCTION OF ENZYME THIOLS-DISULFIDES IN METABOLIC REGULATION

1985 • 840 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors

1983 • 473 citations

Actin-binding proteins—regulators of cell architecture and motility

1982 • 468 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

1985 • 419 citations

Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury

1978 • 409 citations

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

1984 • 376 citations

Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes.

1983 • 375 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide

1983 • 353 citations

Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity.

1985 • 310 citations

On the role of calcium as second messenger in liver for the hormonally induced activation of glycogen phosphorylase

1977 • 309 citations

Calpain and calpastatin

1983 • 304 citations

Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide.

1982 • 303 citations

MITOCHONDRIA AND THE CONTROL OF INTRACELLULAR CALCIUM

1978 • 278 citations

R 24571: A new powerful inhibitor of red blood cell Ca++-transport ATPase and of calmodulin-regulated functions

1981 • 260 citations

Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes.

1985 • 199 citations

Ischemic myocardial cell injury. Prevention by chlorpromazine of an accelerated phospholipid degradation and associated membrane dysfunction.

1979 • 189 citations

Prevention by chlorpromazine of ischemic liver cell death.

1977 • 188 citations

Critical role of sulfhydryl group(s) in ATP‐dependent Ca²⁺ sequestration by the plasma membrane fraction from rat liver

1983 • 172 citations

Inhibition of hepatocyte plasma membrane Ca²⁺‐ATPase activity by menadione metabolism and its restoration by thiols

1985 • 168 citations

Intracellular phospholipases A

1980 • 165 citations

The metabolism of menadione impairs the ability of rat liver mitochondria to take up and retain calcium.

1982 • 159 citations

The effect of sulphydryl-blocking reagents and of urea on the (Na+ + K+)-activated enzyme system

1965 • 149 citations

A Hypothesis for the Role of Dithiol‐Disulfide Interchange in Solute Transport and Energy‐Transducing Processes

1982 • 143 citations

Control of the cytoskeleton by calmodulin and calmodulin-binding proteins

1983 • 132 citations

Serum stimulation of phospholipase A2 and prostaglandin release in 3T3 cells is associated with platelet-derived growth-promoting activity.

1980 • 104 citations

Calcium transport and phosphorylated intermediate of (Ca2+ + Mg2+)-ATPase in plasma membranes of rat liver.

1983 • 100 citations

Purification and properties of human platelet P235. A high molecular weight protein substrate of endogenous calcium-activated protease(s).

1982 • 93 citations

On the role of thiol groups in the inhibition of liver microsomal ca2+ sequestration by toxic agents

1985 • 93 citations

The rat liver plasma membrane high affinity (Ca2+-Mg2+)-ATPase is not a calcium pump. Comparison with ATP-dependent calcium transporter.

1985 • 90 citations

Regulation of protein degradation in muscle by calcium. Evidence for enhanced nonlysosomal proteolysis associated with elevated cytosolic calcium.

1985 • 83 citations

Calcium Regulation in Biological Systems

1985 • 82 citations

Calcium-dependent proteolytic activity in rat liver: Identification of two proteases with different calcium requirements

1981 • 80 citations

Demonstration and partial characterization of glutathione disulfide-stimulated ATPase activity in the plasma membrane fraction from rat hepatocytes.

1985 • 77 citations

Specificity of phospholipases in methylcholanthrene-transformed mouse fibroblasts activated by bradykinin, thrombin, serum, and ionophore A23187.

1979 • 75 citations

Multiple forms of Ca-activated protease from rat brain and muscle.

1984 • 69 citations

Novel ATP-dependent calcium transport component from rat liver plasma membranes. The transporter and the previously reported (Ca2+-Mg2+)-ATPase are different proteins.

1985 • 68 citations

Microsomal membrane structure and function subsequent to calcium activation of an endogenous phospholipase

1980 • 60 citations

A procedure for the rapid isolation from rat liver of plasma membrane vesicles exhibiting Ca2+-transport and Ca2+-ATPase activities

1984 • 57 citations

Role of phospholipid hydrolysis in the mechanism of toxic cell death by calcium and ionophore A23187

1982 • 53 citations

Inhibition of fibrinogen receptor expression and serotonin release by leupeptin and antipain.

1985 • 47 citations

ATP-dependent calcium uptake by rat liver plasma membrane vesicles. Effect of alkylating hepatotoxins in vivo.

1985 • 45 citations

Purification and characterization of a Ca2+-dependent ATPase from rat heart sarcolemma.

1982 • 44 citations

Accumulation of Ca2+ induced by cytotoxic levels of menadione in the isolated, perfused rat liver

1985 • 39 citations

Alterations in intracellular calcium compartmentation following inhibition of calcium efflux from isolated hepatocytes

1984 • 36 citations

Role of Ca2+ for protein turnover in isolated rat hepatocytes

1983 • 28 citations

Calcium-dependent binding of calmodulin to phospholipase A2 subunits induces enzymatic activation

1985 • 17 citations

Cytoplasmic proteases of rat liver parenchymal cells

1982 • 12 citations

Inhibition of glutathione efflux in the recirculating rat liver perfusion by cysteine but not by oxothiazolidine carboxylate, an intracellular cysteine precursor

1984 • 3 citations