Oxidative mechanisms in carcinogenesis

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems

1991 • 1,555 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

Free radicals, antioxidant enzymes, and carcinogenesis

1990 • 1,090 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium

1985 • 1,025 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

1992 • 875 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

New principle for the analysis of chemical carcinogenesis

1976 • 788 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens.

1982 • 747 citations

Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis

1990 • 741 citations

The role of 8-hydroxyguanine in carcinogenesis

1990 • 732 citations

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

1991 • 678 citations

Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.

1991 • 635 citations

Modulation of fibroblast proliferation by oxygen free radicals

1990 • 617 citations

Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide

1991 • 487 citations

DNA strand scission by enzymically generated oxygen radicals

1981 • 428 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction

1989 • 387 citations

Carcinogen-mediated oxidant formation and oxidative DNA damage

1992 • 387 citations

Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage

1990 • 364 citations

Iron Ion-dependent Modification of Bases in DNA by the Superoxide Radical-generating System Hypoxanthine/Xanthine Oxidase

1989 • 363 citations

Diet and Cancer – An Overview

1984 • 336 citations

CONDITIONAL NEOPLASMS AND SUBTHRESHOLD NEOPLASTIC STATES

1941 • 335 citations

Damage to the Bases in DNA Induced by Hydrogen Peroxide and Ferric Ion Chelates

1989 • 332 citations

Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters

1983 • 325 citations

Site-specific mutagenesis using a gapped duplex vector: A study of translesion synthesis past 8-oxodeoxyguanosine in E. coli

1991 • 309 citations

The Role of Croton Oil Applications, Associated with a Single Painting of a Carcinogen, in Tumour Induction of the Mouse's Skin

1947 • 298 citations

Oncogenic Point Mutations in the Human Retinoblastoma Gene: Their Application to Genetic Counseling

1989 • 288 citations

Endogenous oxidative damage of deoxycytidine in DNA.

1992 • 280 citations

Role of superoxide in deoxyribonucleic acid strand scission

1980 • 276 citations

Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells

1983 • 262 citations

Inhibition of Tumor Promotion by a Biomimetic Superoxide Dismutase

1983 • 256 citations

Antioxidants and multistage carcinogenesis in mouse skin

1989 • 232 citations

A developing factor in experimental blastogenesis

1944 • 221 citations

Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene

1992 • 212 citations

Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair

1989 • 201 citations

Hydroxyl radical production and human DNA damage induced by ferric nitrilotriacetate and hydrogen peroxide.

1987 • 196 citations

The fos Oncogene

1987 • 196 citations

Dietary iron and colorectal cancer risk

1992 • 192 citations

The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.

1992 • 174 citations

In vitro DNA binding activity of Fos/Jun and BZLF1 but not C/EBP is affected by redox changes.

1991 • 156 citations

Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide.

1986 • 144 citations

Efficient protection against oxidative DNA damage in chromatin

1992 • 135 citations

Rapid induction of c-fos transcription reveals quantitative linkage of RNA polymerase II and DNA topoisomerase I enzyme activities

1990 • 133 citations

Structure of binary complexes of mono- and polynucleotides with metal ions of the first transition group

1980 • 131 citations

Interaction of copper with DNA and antagonism by other metals

1991 • 129 citations

Mutagenesis by hydrogen peroxide treatment of mammalian cells: a molecular analysis

1990 • 120 citations

Active oxygen induced DNA strand breakage and poly ADP-ribosylation in promotable and non-promotable JB6 mouse epidermal cells

1988 • 119 citations

Phenol sensitization of DNA to subsequent oxidative damage in 8-hydroxyguanine assays

1992 • 113 citations

Oxidants induce phosphorylation of ribosomal protein S6.

1988 • 91 citations

Molecular basis of spontaneous mutation at the aprt locus of hamster cells

1989 • 83 citations

Dietary modulation of DNA damage in human

1991 • 78 citations

Active Oxygen Species as Factors in Multistage Carcinogenesis

1991 • 76 citations

Response modification creates promotability in multistage carcinogenesis

1988 • 74 citations

o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation

1989 • 74 citations

The spectrum of mutations generated by passage of a hydrogen peroxide damaged shuttle vector plasmid through a mammalian host

1989 • 69 citations

Nitrogen-15 nuclear magnetic resonance studies on the tautomerism of 8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine, and other C8-substituted guanine nucleosides

1990 • 67 citations

Free radical-derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide: expanded role for electrophiles in multistage carcinogenesis.

1991 • 64 citations

Role of the benzoyloxyl radical in DNA damage mediated by benzoyl peroxide

1991 • 60 citations

DNA sequence determination of γ-radiation-induced mutations of the hamster aprt locus

1989 • 59 citations

MUTAGENIC EFFECTS OF HIGH OXYGEN TENSIONS ON ESCHERICHIA COLI

1957 • 56 citations

Mutagenicity of hydrogen peroxide in V79 Chinese hamster cells

1987 • 55 citations

Poly(ADP-ribosylation) of histones in intact human keratinocytes

1989 • 53 citations

Pathophysiological mechanismsa of active oxygen

1989 • 53 citations

The enzymic formation and chemical reactivity of quinone methides correlate with alkylphenol-induced toxicity in rat hepatocytes

1992 • 52 citations

Hydrogen peroxide activates immediate binding of a Drosophila factor to DNA heat‐shock regulatory element in vivo and in vitro

1990 • 48 citations

Toxicity, cell proliferation, and carcinogenesis

1992 • 27 citations

Removing Oxygen-Derived Free Radicals Delays Hepatic Metastases and Prolongs Survival in Colonic Cancer

1992 • 25 citations

Constitutive and phorbol‐myristate‐acetate regulated antioxidant defense of mouse epidermal JB6 cells

1989 • 25 citations

Oxygen Supply and Stability of Chromosomes in Mouse Embryo Cells <italic>In Vitro</italic><xref ref-type="fn" rid="FN1">2</xref>

1971 • 18 citations

DNA damage, environmental toxicants, and rate of aging

1991 • 13 citations

Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189

1992 • 13 citations